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- isopropamide iodide
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/03/17 19:57:29」(JST)
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Isopropamide
|
Systematic (IUPAC) name |
4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium |
Clinical data |
MedlinePlus |
a694006 |
Legal status |
- US: Rx-only, Unscheduled
- Unscheduled
|
Routes |
Oral |
Identifiers |
CAS number |
7492-32-2 N |
ATC code |
A03AB09 |
PubChem |
CID 3775 |
DrugBank |
DB01625 |
ChemSpider |
3643 Y |
UNII |
8B9I31H724 Y |
ChEMBL |
CHEMBL1201232 N |
Chemical data |
Formula |
C23H33N2O1 + |
Molecular mass |
353.52092 g/mol |
SMILES
- O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C
|
InChI
-
InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1 Y
Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O Y
|
N (what is this?) (verify) |
Isopropamide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.
§References
- Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
- Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- to treat nausea and vomiting
- other
|
|
|
English Journal
- Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.
- Abbas SS, Zaazaa HE, Abdelkawy M, Abdelrahman MM.SourceAnalytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562 Cairo, Egypt.
- Drug testing and analysis.Drug Test Anal.2010 Apr;2(4):168-81.
- Four sensitive, selective and precise stability indicating methods for the determination of isopropamide iodide (ISO) and trifluoperazine hydrochloride (TPZ) in their binary mixture and in presence of trifluoperazine oxidative degradate (OXD). Method A is a derivative spectrophotometric one, where I
- PMID 20376832
- Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product.
- El-Gindy A, El-Zeany B, Awad T, Shabana MM.SourcePharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt. ghada74@ismailia.ie-eg.com
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2002 Jan 1;27(1-2):9-18.
- Three methods are presented for the determination of trifluoperazine HCl in presence of its hydrogen peroxide induced degradation product. The first method was based on measurement of first (1D) and second (2D) derivative amplitudes of trifluoperazine HCl in 0.1 N hydrochloric acid at the zero cross
- PMID 11682205
Japanese Journal
- Isopropamide Iodideのラット胃腸管吸収におよぼすトリクロロ酢酸の併用効果
- 後藤 茂,吉富 博則,福池 厚子
- 藥學雜誌 97(8), 867-872, 1977-08-25
- … Pharmacological response and diameter of a pupil in the rat were examined after oral administration of isopropamide iodide when given in combination with 50-fold molar excess of trichloroacetate in solution and compared with those after single administration of isopropamide iodide. …
- NAID 110003661247
- 後藤 茂,吉富 博則,藤井 勝蔵
- 藥學雜誌 97(7), 801-804, 1977-07-25
- … On the other hand, when these quaternary ammonium salts were administered subcutaneously, a retardation of stomach emptying rate was observed thirty minutes after oral administration of phenol red and its extent was given in the following order, isopropamide iodie>benzilonium bromide>benactyzine methobromide=anisotropine methobromide>propantheline bromide. …
- NAID 110003652607
Related Links
- Isopropamide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity ( gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ...
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- isopropamide、isopropamide iodide
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- isopropamide