WordNet

hypoxia resulting from slow peripheral circulation (such as follows congestive cardiac failure) (同)stagnant hypoxia
relating to or affected by ischemia (同)ischaemic
oxygen deficiency causing a very strong drive to correct the deficiency

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1. 低酸素血症の酸素供給およびメカニズムoxygenation and mechanisms of hypoxemia [show details]
… as a whole (general hypoxia) or to a specific region (tissue hypoxia). In this topic review, measures of oxygenation and mechanisms of hypoxemia are discussed.… pure hypoventilation include: CNS depression, such as drug overdose, structural CNS lesions, or ischemic CNS lesions that impact the respiratory center; Obesity hypoventilation (Pickwickian) syndrome; …
2. 鎌状赤血球症の臨床症状の概要overview of the clinical manifestations of sickle cell disease [show details]
… Ischemic stroke is more common than hemorrhagic stroke in children and adolescents with SCD; hemorrhagic stroke is more common in adults. Other neurovascular events including transient ischemic attacks… degree of hypoxia is significantly greater in SCD than controls and is associated with a more severe and longer period of nocturnal desaturation. The cause of nocturnal hypoxemia in SCD is multifactorial…
3. 循環障害における肝障害の病因pathogenesis of liver injury in circulatory failure [show details]
… the clinical setting . In a study of 142 patients with ischemic hepatitis, liver hypoxia was thought to result mostly from profound systemic hypoxemia in those with chronic respiratory failure, while in those …
4. 高山病：生理学、危険因子、および一般的な予防法high altitude illness physiology risk factors and general prevention [show details]
… hypertension; preexisting medical conditions exacerbated by hypoxia, such as ischemic heart disease; and conditions arising at altitude unrelated to hypoxia, such as frostbite and photokeratitis. Many of these …
5. 新生児の脳卒中：分類、臨床症状、診断stroke in the newborn classification manifestations and diagnosis [show details]
…infarcts made up another 9 percent . Although perinatal hypoxia-ischemia is sometimes implicated in the pathogenesis of arterial ischemic stroke, hypoxia and/or ischemia rarely are documented. Conversely, term …

English Journal

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW 2nd, Trimarco B, Feliciello A, Iaccarino G.SourceClinical Medicine, Cardiovascular and Immunological Sciences "Federico II" University, Naples, Italy.
Cellular signalling.Cell Signal.2012 Feb;24(2):468-75. Epub 2011 Oct 1.
Metabolic stimuli such as insulin and insulin like growth factor cause cellular accumulation of G protein coupled receptor kinase 2 (GRK2), which in turn is able to induce insulin resistance. Here we show that in fibroblasts, GRK2 is able to increase ATP cellular content by enhancing mitochondrial b
PMID 21983013

mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen-activated protein kinase signaling pathway.

Zhao L, Jiao Q, Chen X, Yang P, Zhao B, Zheng P, Liu Y.SourceInstitute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi'an Jiaotong University College of Medicine, Xi'an, China.
Journal of neuroscience research.J Neurosci Res.2012 Feb;90(2):447-60. doi: 10.1002/jnr.22751. Epub 2011 Oct 27.
Hypoxia/ischemia induces proliferation of neural progenitor cells (NPCs) in rodent and human brain; however, the mechanisms remain unknown. We investigated the effects of metabotropic glutamate receptor 5 (mGluR5) on NPC proliferation under hypoxia, the expression of cyclin D1, and the activation of
PMID 22034224

Japanese Journal

Chronic treatment with a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (MAK) prevents apoptosis and necroptosis in hypoxia/ischemia-induced injury of type 2 diabetic mouse brain

玄美燕,岡﨑真理,岩田直洋,浅野哲,神内伸也,松崎広和,坂本武史,Miyano Yoshiyuki,飯塚博,日比野康英
Evidence-based complementary and alternative medicine 2015(865986), 1-29, 2015-02-03
… Type 2 diabetes mellitus has been known to increase systemic oxidative stress by chronic hyperglycemia and visceral obesity and aggravate cerebral ischemic injury. …
NAID 120005590299

Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning

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Circulation Journal advpub(0), 2015
… Background:Remote ischemic preconditioning (RIPC) induced by transient limb ischemia is a powerful innate mechanism of cardioprotection against ischemia. … In mice, RIPC rapidly upregulated EPO mRNA and its main transcriptional factor, hypoxia-inducible factor-1α (HIF1α), in the kidney. …
NAID 130005063501

Hypoxia-Sensitive Reporter System for High-Throughput Screening

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The Tohoku Journal of Experimental Medicine 235(2), 151-159, 2015
… The induction of anti-hypoxic stress enzymes and proteins has the potential to be a potent therapeutic strategy to prevent the progression of ischemic heart, kidney or brain diseases. … However, to date, none of these compounds were identified by monitoring the transcriptional activation of hypoxia-inducible factors (HIFs). …
NAID 130004822440