WordNet

the amount that can be contained; "the gas tank has a capacity of 12 gallons" (同)content
(computer science) the amount of information (in bytes) that can be stored on a disk drive; "the capacity of a hard disk drive is usually expressed in megabytes"
a specified function; "he was employed in the capacity of director"; "he should be retained in his present capacity at a higher salary"
the maximum production possible; "the plant is working at 80 per cent capacity"
tolerance for alcohol; "he had drunk beyond his capacity"
the power to learn or retain knowledge; in law, the ability to understand the facts and significance of your behavior (同)mental ability
capability to perform or produce; "among his gifts is his capacity for true altruism"; "limited runway capacity"; "a great capacity for growth"
press and smooth with a heated iron; "press your shirts"; "she stood there ironing" (同)iron_out, press
a heavy ductile magnetic metallic element; is silver-white in pure form but readily rusts; used in construction and tools and armament; plays a role in the transport of oxygen by the blood (同)Fe, atomic number 26
implement used to brand live stock (同)branding iron
home appliance consisting of a flat metal base that is heated and used to smooth cloth (同)smoothing iron
a golf club that has a relatively narrow metal head
executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
garments (clothes or linens) that are to be (or have been) ironed; "there was a basketful of ironing to do"
the work of using heat to smooth washed clothes in order to remove any wrinkles
(of linens or clothes) smoothed with a hot iron

PrepTutorEJDIC

〈U〉《しばしばa capacity》(建物などの)『収容力』,(容器などの)『容量』,『容積』 / 〈U〉《しばしばa capacity》(人の)『能力』,才能;(物の)性能 / 〈C〉(…の)『資格』,地位《+『of』(『as』)+『名』》
〈U〉『鉄』 / 〈U〉鉄のように堅い(強い,冷たい)こと / 〈C〉鉄製の器具 / 〈C〉[電気]『アイロン』 / 〈C〉アイアン(球を打つ部分が金属のゴルフクラブ) / 〈C〉《複数形で》手かせ,足かせ / 《名詞の前にのみ用いて》『鉄の』,鉄製の / 鉄のように堅い(強い,冷たい) / …‘に'アイロンをかける / 〈人が〉アイロンをかける
義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
アイロンかけ / アイロンかけをした(をする)衣類

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/09 08:21:45」(JST)

wiki en

Total iron-binding capacity (TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin.^[1] It is performed by drawing blood and measuring the maximum amount of iron that it can carry, which indirectly measures transferrin^[2] since transferrin is the most dynamic carrier. TIBC is less expensive than a direct measurement of transferrin.^[3]^[4]

The TIBC should not be confused with the UIBC, or "unsaturated iron binding capacity" (22753-8 and 35216-1). The UIBC is calculated by subtracting the serum iron from the TIBC.^[5]

Interpretation

Taken together with serum iron and percent transferrin saturation clinicians usually perform this test when they are concerned about anemia, iron deficiency or iron deficiency anemia. However, because the liver produces transferrin, alterations in function (such as cirrhosis, hepatitis, or liver failure) must be considered when performing this test. It can also be an indirect test of liver function, but is rarely used for this purpose.

The percent transferrin saturation (i.e., the result of the formula of serum iron/TIBC x 100) can also be a useful indicator.

Condition	Serum iron (highly variable)	Transferrin and TIBC	Percent transferrin saturation
iron deficiency anemia	Low	High. The liver produces more transferrin, presumably attempting to maximize use of the little iron that is available.	Low, as there is insufficient iron.
anemia of chronic disease	Low, as the body holds iron intracellularly with ferritin.	Low. The body produces less transferrin (but more ferritin), presumably to keep iron away from pathogens that require it for their metabolism. This is mainly regulated by increased hepcidin production.	Normal
pregnancy or use of hormonal contraception, but without iron deficiency	Normal	High. The liver increases the production of transferrin, thus raising TIBC.	Low, as there is excess transferrin with normal serum iron levels.

These examples demonstrate that to properly understand a value for TIBC, one also must know the serum iron, the percent transferrin saturation, and the individual clinical situation. In modern laboratory testings, serum ferritin levels are generally accepted as reliable single indicators of the presence of iron deficiency.

Usual values

Reference ranges for blood tests, comparing blood content of iron and related compounds (shown in brown and orange) with other constituents.

Laboratories often use different units of measurement and "normal" may vary by population and the laboratory techniques used. Look at the individual laboratory reference values to interpret a specific test (for instance, your own). Example reference ranges are:

Serum iron: Male 65–177 μg/dL (11.6–31.7 μmol/L); Female 50–170 μg/dL (9.0–30.4 μmol/L)
TIBC: 250–370 μg/dL (45-66 μmol/L)^[6]
Transferrin saturation: Male 20–50%; Female 15–50%
Serum ferritin: Male 20-250 μg/L, Female 15-150 μg/L^[6]

μg/dL = micrograms per deciliter; μmol/L = micromoles per litre.

References

^ "MedlinePlus Medical Encyclopedia: Total iron binding capacity". Retrieved 2008-12-31.
^ Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y (January 2003). "Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity". Clin. Chem. 49 (1): 175–8. doi:10.1373/49.1.175. PMID 12507977.
^ Kasvosve I, Delanghe J (October 2002). "Total iron binding capacity and transferrin concentration in the assessment of iron status". Clin. Chem. Lab. Med. 40 (10): 1014–8. doi:10.1515/CCLM.2002.176. PMID 12476940.
^ Gambino R, Desvarieux E, Orth M, et al. (December 1997). "The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum". Clin. Chem. 43 (12): 2408–12. PMID 9439462.
^ "Iron Transport". Retrieved 2008-12-31.
^ ^a ^b Harrison's Principles of Internal Medicine. 17th Edition (2008). Pg. 2432 (Table 351-2)

External Links

TIBC, UIBC and Transferrin Saturation at Lab Tests Online

UpToDate Contents

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1. 成人における鉄欠乏性貧血の原因および診断 causes and diagnosis of iron deficiency anemia in the adult
2. 乳幼児における鉄欠乏：スクリーニング、予防、臨床症状、および診断 iron deficiency in infants and young children screening prevention clinical manifestations and diagnosis
3. 鉄のバランス調節 regulation of iron balance
4. 鉄過剰症候群の病態生理および診断 pathophysiology and diagnosis of iron overload syndromes
5. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia

English Journal

Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children.

Lee HR1,2, Shin S3,4,5, Yoon JH3,4,6, Roh EY3,4,7, Chang JY8.
Annals of laboratory medicine.Ann Lab Med.2016 Sep;36(5):481-8. doi: 10.3343/alm.2016.36.5.481.
BACKGROUND: Reference intervals need to be established according to age. We established reference intervals of hematology and chemistry from community-based healthy 1-yr-old children and analyzed their iron status according to the feeding methods during the first six months after birth.METHODS: A to
PMID 27374715

Anemia, Iron Deficiency and Iodine Deficiency among Nepalese School Children.

Khatiwada S1, Lamsal M2, Gelal B2, Gautam S2, Nepal AK2, Brodie D3, Baral N2.
Indian journal of pediatrics.Indian J Pediatr.2016 Jul;83(7):617-21. doi: 10.1007/s12098-015-1924-y. Epub 2015 Nov 12.
OBJECTIVES: To assess iodine and iron nutritional status among Nepalese school children.METHODS: A cross-sectional, community based study was conducted in the two districts, Ilam (hilly region) and Udayapur (plain region) of eastern Nepal. A total of 759 school children aged 6-13 y from different sc
PMID 26558919

Isolated Effects of Renal Failure, Anthropometric Indices, and Serum Total Iron-Binding Capacity as Determinants of Muscle Performance in Hemodialysis Patients.

Bučar Pajek M1, Svilan K2, Vivoda T2, Škoberne A3, Pajek J4.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.J Ren Nutr.2016 Jul;26(4):245-52. doi: 10.1053/j.jrn.2015.12.005. Epub 2016 Jan 27.
OBJECTIVE: We quantified the isolated impact of end-stage renal disease (ESRD) on physical performance under contemporary hemodialysis treatment independent of comorbid diseases, characterized principal anthropometric components, and adjusted for their influence and compared associations of C-reacti
PMID 26827132

Japanese Journal

Predictors of Long-Term Mortality in Patients Hospitalized in an Intensive Cardiac Care Unit:A Special Role of Anemia and Iron Status

International Heart Journal 57(1), 67-72, 2016
NAID 130005120992

Predictors of Long-Term Mortality in Patients Hospitalized in an Intensive Cardiac Care Unit:A Special Role of Anemia and Iron Status

International Heart Journal advpub(0), 2016
NAID 130005114566

Related Pictures

★リンクテーブル★

リンク元	「鉄結合能」
関連記事	「binding」「capacity」「iron」

「鉄結合能」

Total iron-binding capacity
	Diagnostics
	The transferrin molecule binds free iron and transports it in the blood.
MedlinePlus	003489
LOINC	14800-7, 35215-3, 2501-5
	[edit on Wikidata]