イオノフォア
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/16 21:04:15」(JST)
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An ionophore is a chemical species that reversibly binds ions.[1] Many ionophores are lipid-soluble entities that transport ions across a cell membrane. Ionophore means "ion carrier" as these compounds catalyze ion transport across hydrophobic membranes such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes)[1]
Some ionophores are synthesized by microorganisms to import ions into their cells. Synthetic ion carriers have also been prepared. Ionophores selective for cations and anions have found many applications in analysis.[2]
The two broad classifications of ionophores synthesized by microorganisms are:
- Carrier ionophores that bind to a particular ion and shield its charge from the surrounding environment. This makes it easier for the ion to pass through the hydrophobic interior of the lipid membrane.[3] An example of a carrier ionophore is valinomycin, a molecule that transports a single potassium cation. Carrier ionophores may be proteins or other molecules.
- Channel formers that introduce a hydrophilic pore into the membrane, allowing ions to pass through without coming into contact with the membrane's hydrophobic interior.[4] An example of a channel former is gramicidin A. Channel forming ionophores are usually large proteins.
Contents
- 1 Mechanism of action of biologically relevant ionophores
- 2 Synthetic ionophores
- 3 List of representative biological ionophores
- 4 See also
- 5 References
- 6 External links
Mechanism of action of biologically relevant ionophores
The structure of the complex of sodium (Na
+) and the antibiotic monensin A
Transmembrane ion concentration gradients (membrane potential) are required for living organisms. Ionophores can disrupt the membrane potential by conducting ions through a lipid membrane in the absence of a protein pore, and thus could exhibit cytotoxic properties. They are produced naturally by a variety of microbes and act as a defense against competing microbes.
Many antibiotics, particularly the macrolide antibiotics, are ionophores. Some exhibit high affinities for Na+, others high affinities for K+.[5] The structure of the sodium and potassium complexes of antibiotics have been verified by X-ray crystallography.[6]
Ionophores have been used to modify the permeability of biological membranes toward certain ions. Additionally, some ionophores are used as antibiotics and/or as growth-enhancing feed additives for certain animals, such as cattle (see monensin) and chickens.[7]
Synthetic ionophores
Structure of a potassium complex of a crown ether, a synthetic ionophore-ion complex
Many synthetic ionophores are based on crown ethers, cryptands, and calixarenes. These synthetic species are often macrocyclic.[5] Some synthetic agents are not macrocyclic, e.g., carbonyl cyanide-p-trifluoromethoxyphenylhydrazone. Even simple organic compounds, such as phenols, exhibit ionophoric properties. The majority of synthetic receptors used in the carrier-based anion-selective electrodes employ transition elements or metalloids as anion carriers, although simple organic urea- and thiourea based receptors are known.
List of representative biological ionophores
With the ion(s) they act upon:
- Beauvericin (Ca2+, Ba2+)
- Calcimycine or A23187 (Mn2+, Ca2+, Mg2+)
- Carbonyl cyanide m-chlorophenyl hydrazone (CCCP) (H+)
- Enniatin (ammonium)
- Gramicidin A (H+, Na+, K+)
- Ionomycin (Ca2+)
- Lasalocid (K+, Na+, Ca2+, Mg2+)[8]
- Monensin (Na+, H+)
- Nigericin (K+, H+, Pb2+)
- Nonactin (ammonium ionophore I)
- Nystatin (K+)
- Salinomycin (K+)
- Valinomycin (potassium ionophore I)
See also
- Siderophore - Fe3+ binding compounds, found in microbes and grasses
References
- ^ a b Bakker E1, Bühlmann P, Pretsch E. (1997). "Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics". Chem Rev. 97 (8): 3083–3132. doi:10.1021/cr940394a.
- ^ Bühlmann P1, Pretsch E, Bakker E. (1998). "Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors". Chem Rev. 98 (4): 1593–1688. doi:10.1021/cr970113+.
- ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version: (2006–) "Ionophore".
- ^ "Ionophores - MeSH Result".
- ^ a b Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 0-08-037941-9.
- ^ Steinrauf, L. K.; Hamilton, J. A.; Sabesan, M. N. (1982). "Crystal structure of valinomycin-sodium picrate. Anion effects on valinomycin-cation complexes". Journal of the American Chemical Society 104 (15): 4085–4091. doi:10.1021/ja00379a008.
- ^ Kabel, Marcus; Christine Simmons (2007-11-20). "USDA Revokes OK for Tyson Chicken Labels". Archived from the original on November 24, 2007. Retrieved 2007-11-20.
- ^ Antonenko, YN; Yaguzhinsky, LS (18 February 1988). "The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid A.". Biochimica et Biophysica Acta 938 (2): 125–30. doi:10.1016/0005-2736(88)90151-4. PMID 19927398.
External links
- Fluka ionophores for ion-selective electrodes
- Medical Information database Reference.MD
- Structures and Properties of Naturally Occurring Polyether Antibiotics, J. Rutkowski, B. Brzezinski; open access review article
- Polyether ionophores—promising bioactive molecules for cancer therapy, A. Huczyński; open access review article
UpToDate Contents
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English Journal
- Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells.
- Ishida M, Nishi K, Watanabe H, Sugahara T.SourceFaculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan.
- Food chemistry.Food Chem.2013 Jan 15;136(2):322-7. doi: 10.1016/j.foodchem.2012.08.079. Epub 2012 Sep 8.
- The inhibitory effect of an aqueous extract from spinach on degranulation of RBL-2H3 cells is herein reported. The extract significantly suppressed antigen-induced degranulation in a dose-dependent manner without affecting cell viability. Active substances in the extract were heat-stable and trypsin
- PMID 23122065
- Calcineurin-nuclear factor of activated t cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP.
- Kipanyula MJ, Woodhoo A, Rahman M, Payne D, Jessen KR, Mirsky R.SourceDepartment of Veterinary Anatomy, Sokoine University of Agriculture, Chuo Kikuu, Morogoro, Tanzania.
- Journal of neuroscience research.J Neurosci Res.2013 Jan;91(1):105-15. doi: 10.1002/jnr.23131. Epub 2012 Oct 17.
- The transcription factor Krox-20 (Egr2) is a master regulator of Schwann cell myelination. In mice from which calcineurin B had been excised in cells of the neural crest lineage, calcineurin-nuclear factor of activated T cells (NFAT) signaling was required for neuregulin-related Schwann cell myelina
- PMID 23073893
Japanese Journal
- 育成期のイオノフォア飼料添加が黒毛和種の産肉性および肉質に及ぼす影響
- 椿 由江,浅田 勉,角田 成幸
- 群馬県畜産試験場研究報告 = Bulletin of the Gunma Prefectural Livestock Experiment Station (20), 10-25, 2013-12
- NAID 40019973167
- Effect of triclocarban on membrane potential of rat thymocytes : Assessment with bis-(1,3-dibutylbarbituric acid)trimethine oxonol
- Sun Yuanzhi,Enkhjargal Molomjamts,Sugihara Aya,Yamada Saki,Chen Xiaohui,Miura Yukari,Fukunaga Eri,Satoh Masaya,Oyama Yasuo,佐藤 征弥,小山 保夫
- 徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima 27(4), 53-59, 2013-10
- … To see if TCC inhibits Ca2+-dependent hyperpolarization, the effect of A23187, a calcium ionophore, on the membrane potential was examined in the cells treated with TCC. …
- NAID 120005352784
- Flow-Injection Potentiometry by Poly(vinyl chloride)-Membrane Electrodes with Diphosphoryl-dicarboxylicacid-p-tert-butylcalix〔4〕arene Ionophore for the Determination of Th(Ⅳ) Ions
- MIZANI Farhang,SHAMSIPUR Mojtaba,YAFTIAN Mohammad R. [他]
- Analytical Sciences 29(3), 361-366, 2013-03
- NAID 40019602924
Related Links
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