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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/11 02:46:40」(JST)

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The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN), can be used in the treatment of amoebiasis.^[1]

It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism.^[2]

It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.^[3]

Susceptibility of Dientamoeba fragilis has been measured.^[4]

Iodoquinol is an amebocide used against Entamoeba histolytica, and it is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.

References

^ Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578.
^ Gideon Online http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General. Missing or empty |title= (help)
^ Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
^ Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F (May 1994). "Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole". Antimicrob. Agents Chemother. 38 (5): 1157–60. doi:10.1128/aac.38.5.1157. PMC 188168. PMID 8067755.

UpToDate Contents

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1. 赤痢アメーバによる腸菅アメーバ症 intestinal entamoeba histolytica amebiasis
2. 抗原虫治療 antiprotozoal therapies
3. カンジダ性間擦疹 candidal intertrigo
4. 二核アメーバ dientamoeba fragilis
5. 赤痢アメーバによる腸菅外アメーバ症 extraintestinal entamoeba histolytica amebiasis

English Journal

Treatment failure in patients with chronic Blastocystis infection.

Roberts T1, Ellis J, Harkness J, Marriott D, Stark D.
Journal of medical microbiology.J Med Microbiol.2014 Feb;63(Pt 2):252-7. doi: 10.1099/jmm.0.065508-0. Epub 2013 Nov 15.
This article reports long-term infection and treatment failure in 18 symptomatic individuals infected with Blastocystis spp. Patients were initially treated with either metronidazole, iodoquinol or triple combination therapy consisting of nitazoxanide, furazolidone and secnidazole. Following treatme
PMID 24243286

Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture.

Ali NW1, Gamal M, Abdelkawy M.
Pakistan journal of pharmaceutical sciences.Pak J Pharm Sci.2013 Sep;26(5):865-71.
Two chromatographic methods were developed for analysis ofdiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, diiodohydroxyquinoline and metronidazole were separated on TLC silica gel 60F254 plate using chloroform: acetone: glacial acetic acid (7.5: 2.5: 0.1, by volume) as mo
PMID 24035940

Amoebic dysentery.

Marie C1, Petri WA Jr.
BMJ clinical evidence.BMJ Clin Evid.2013 Aug 30;2013. pii: 0918.
INTRODUCTION: Amoebic dysentery is caused by the protozoan parasite Entamoeba histolytica. It is transmitted in areas where poor sanitation allows contamination of drinking water and food with faeces. In these areas, up to 40% of people with diarrhoea may have amoebic dysentery.METHODS AND OUTCOMES:
PMID 23991750

Japanese Journal

Effects of Clioquinol Analogues on the Hypoxia-Inducible Factor Pathway and Intracelullar Mobilization of Metal Ions

Kim So Yeon,Lee Myong Jin,Kim Jeong Won [他],Na Yu-Ran,Lee Ho-Youl,Cho Hyunju,Lee Keun Byeol,Lee You Mie,Lee Cheolju,Park Hyunsung,Yang Eun Gyeong
Biological and Pharmaceutical Bulletin 35(12), 2160-2169, 2012
… Here we report that compounds derived from 8-hydroxyquinoline including CQ, broxyquinoline (BQ), iodoquinol (IQ) and chloroacetoxyquinoline (CAQ) promote neovascularization effectively based on chick chorioallantoic membrane assays. …
NAID 130002480505

Pleural Empyema Secondary to Rupture of Amoebic Liver Abscess

Chang Huai-Ren,Lee Jen-Jyh,Lin Chih-Bin
Internal Medicine 51(5), 471-474, 2012
… Using chest tube and percutaneous liver abscess drainage, the patient was treated with metronidazole followed by iodoquinol. …
NAID 130002061901

Preparation of a Novel Iodide-Selective Electrode Based on Iodide-Miconazole Ion-Pair and Its Application to Pharmaceutical Analysis

JALALI Fahimeh,RAJABI Mohammad J.,BAHRAMI Gholamreza,SHAMSIPUR Mojtaba
Analytical Sciences 21(12), 1533-1535, 2005
… The membrane sensor was successfully applied to the determination of iodide in water samples and blood serum, as well as in pharmaceutical products such as iodoquinol and thyroxin. …
NAID 130004441043

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★リンクテーブル★

リンク元	「ヨードキノール」「diiodohydroxyquinoline」

「ヨードキノール」

Diiodohydroxyquinoline
Names
	IUPAC name 5,7-diiodoquinolin-8-ol
	Other names Diquinol, iodoxin, diiodoquin, amebaquin
Identifiers
CAS Number	83-73-8
ChEMBL	ChEMBL86754
ChemSpider	3597
Jmol interactive 3D	Image
KEGG	D00581
MeSH	Iodoquinol
PubChem	3728
UNII	63W7IE88K8
	InChI InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key: UXZFQZANDVDGMM-UHFFFAOYSA-N ; InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key: UXZFQZANDVDGMM-UHFFFAOYAF ;
	SMILES C1=CC2=C(C(=C(C=C2I)I)O)N=C1 ;
Properties
Chemical formula	C9H5I2NO
Molar mass	396.951
Pharmacology
ATC code	G01AC01
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references