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1. 透析前慢性腎臓病または末期腎不全を伴う2型糖尿病患者における高血糖のマネージメントmanagement of hyperglycemia in patients with type 2 diabetes and pre dialysis chronic kidney disease or end stage renal disease [show details]
… in a small study in patients with type 2 diabetes and CKD undergoing intravenous iron or erythropoietin therapy,… New test strips have been designed to minimize interference with non-glucose sugars .… and tolbutamide) have been largely replaced by newer agents such as glyburide,…
2. ビリルビン過剰産生によるジルベール症候群および高非抱合型ビリルビン血症gilbert syndrome and unconjugated hyperbilirubinemia due to bilirubin overproduction [show details]
… Another provocative test is to administer intravenous nicotinic acid,… other drugs that require bilirubin-UGT-mediated hepatic glucuronidation are acetaminophen and tolbutamide, although it is unclear if alterations in glucuronidation of these drugs has clinical significance …
3. 妊娠糖尿病：血糖コントロールおよび母体の予後gestational diabetes mellitus glycemic control and maternal prognosis [show details]
… to order the test prior to this visit, so the results are available for counseling and so the test can be rescheduled if it has been missed. A fasting plasma glucose test is a reasonable… therapy should be counseled regarding the limited information about these important questions. Tolbutamide or chlorpropamide (older sulfonylureas) therapy is not recommended in women with gestational diabetes …
4. 糖尿病の治療におけるスルホニル尿素およびメグリチニドsulfonylureas and meglitinides in the treatment of diabetes mellitus [show details]
… and because of old studies that suggested increased cardiovascular risk (tolbutamide) Glipizide,… reactions (including pruritus, erythema, rash, urticaria, photosensitivity), and abnormal liver function tests. In a patient with a past allergic reaction to one sulfonylurea, it is best to avoid other similar…
5. 甲状腺ホルモンとの薬物相互作用drug interactions with thyroid hormones [show details]
…lanthanum carbonate, and chromium have been shown to reduce T4 absorption in a formal six-hour absorption test . It is prudent to separate the administration of these drugs and T4 by several hours. Phenobarbital…

English Journal

Development and validation of a highly sensitive LC-MS/MS-ESI method for quantification of IIIM-019-A novel nitroimidazole derivative with promising action against Tuberculosis: Application to drug development.

Kour G, Chandan BK, Khullar M, Munagala G, Singh PP, Bhagat A, Gupta AP, Vishwakarma RA, Ahmed Z.
Journal of pharmaceutical and biomedical analysis. 2016 May;124()26-33.
The study aims to illustrate an analytical validation of a rapid and sensitive liquid chromatography (LC) coupled to tandem mass spectrometry (MS-MS) and electrospray ionization (ESI) method for quantification of IIIM-019 (a novel nitroimidazole derivative with potential activity against Tuberculosi
PMID 26922579

High heritability and genetic correlation of intravenous glucose- and tolbutamide-induced insulin secretion among non-diabetic family members of type 2 diabetic patients.

Gjesing AP, Hornbak M, Allin KH, Ekstrøm CT, Urhammer SA, Eiberg H, Pedersen O, Hansen T.
Diabetologia. 2014 Jun;57(6)1173-81.
The aim of this study was to estimate the heritability of quantitative measures of glucose regulation obtained from a tolbutamide-modified frequently sampled IVGTT (t-FSIGT) and to correlate the heritability of the glucose-stimulated beta cell response to the tolbutamide-induced beta cell response.
PMID 24604100

Glucocorticoid overexposure in neonatal life alters pancreatic beta-cell function in newborn foals.

Jellyman JK, Allen VL, Holdstock NB, Fowden AL.
Journal of animal science. 2013 Jan;91(1)104-10.
Studies in humans and animals have linked abnormal programming of adult tissue function to excess glucocorticoids during perinatal development. The current study investigated the hypothesis that physiological variations in glucocorticoid concentrations during early neonatal life of the foal alter th
PMID 23100584

Japanese Journal

Plasma insulin response to various secretagogues in insulinoma.

OHNEDA AKIRA,KOBAYASHI TAKASHI,NIHEI JIRO
The Tohoku Journal of Experimental Medicine 136(4), 447-457, 1982
… In the intravenous tolbutamide test, plasma IRI increased conspicuously to 82-1, 330μU/ml and hypoglycemic coma was provoked in 54%. … Plasma IRI was elevated in the intravenous glucagon test and reached the peak levels of 85-400μU/ml, which exceeded those of the control group. …
NAID 130003492949

血液ろ過法

山上征二,岸本武利
人工臓器 10(2), 624-627, 1981
… Their body weight was within 2.5% range from the standard and subject with diabetes mellitus was excluded.<br>0.5/kg of intravenous glucose tolerance test (ivGTT) was started from 9A.M. on these 3 fasted groups. …
NAID 130001737470

微小インスリノーマ部位診断への人工膵島の応用:ブドウ糖注入機構による血糖制御を指標として

河盛隆造 [他],坂口寛正,中尾量保,東堂龍平,山崎義光,清水靖久,七里元亮,阿部裕,宮田正彦,浜路政靖,坂本嗣郎
糖尿病 23(9), 851-859, 1980
著者らがすでに開発したブドウ糖注入機構を備えた人工膵島は, 人工臓器の治療機器としての安全性の確保のみならず各種低血糖症への治療適応の拡大を可能とした.今回, 低血糖性昏睡を主訴とする患者の術前検査および術中血糖管理に本システムを応用した.<BR>症例は選択的膵動脈撮影やpercutaneous tramhepatic portography下での, 選択的膵静脈catheteriza …
NAID 130004336875