WordNet

(genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism (同)genetic mutation, chromosomal_mutation
a change or alteration in form or qualities
arising or occurring within a species; involving the members of one species; "intraspecific competition" (同)intraspecific

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1. プロトロンビンG20210A変異 prothrombin g20210a mutation
2. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法 systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor
3. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
4. ドライバー変異が認められない進行非小細胞肺癌の初期マネージメントのための全身療法 systemic therapy for the initial management of advanced non small cell lung cancer without a driver mutation
5. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera

Loh JT1, Gaddy JA2, Algood HM3, Gaudieri S4, Mallal S5, Cover TL6.
Infection and immunity.Infect Immun.2015 Dec;83(12):4871-83. doi: 10.1128/IAI.00918-15. Epub 2015 Oct 5.
Helicobacter pylori exhibits a high level of intraspecies genetic diversity. In this study, we investigated whether the diversification of H. pylori is influenced by the composition of the diet. Specifically, we investigated the effect of a high-salt diet (a known risk factor for gastric adenocarcin
PMID 26438795

Rare Events of Intragenus and Intraspecies Horizontal Transfer of the 16S rRNA Gene.

Tian RM1, Cai L1, Zhang WP1, Cao HL1, Qian PY2.
Genome biology and evolution.Genome Biol Evol.2015 Jul 27;7(8):2310-20. doi: 10.1093/gbe/evv143.
Horizontal gene transfer (HGT) of operational genes has been widely reported in prokaryotic organisms. However, informational genes such as those involved in transcription and translation processes are very difficult to be horizontally transferred, as described by Woese's complexity hypothesis. Here
PMID 26220935

Gene Loss Dominates As a Source of Genetic Variation within Clonal Pathogenic Bacterial Species.

Bolotin E1, Hershberg R2.
Genome biology and evolution.Genome Biol Evol.2015 Jul 10;7(8):2173-87. doi: 10.1093/gbe/evv135.
Some of the most dangerous pathogens such as Mycobacterium tuberculosis and Yersinia pestis evolve clonally. This means that little or no recombination occurs between strains belonging to these species. Paradoxically, although different members of these species show extreme sequence similarity of or
PMID 26163675

Komatsu Katsuko,Yang Dong-Ye,Fushimi Hirotoshi [他],CAI Shao Qing
和漢医薬学雑誌 22(Supplement_1), 70-85, 2005
… The sequence comparison of the matK gene revealed that most species had variable sequences not only inter- but also intraspecies. … On the basis of the above marker nucleotides, a convenient and efficient identification method employing Polymerase Chain Reaction-Restriction Fragment Length Polymorphism and Amplification Refractory Mutation System analyses was further developed. …
NAID 110002555177