intramembrane

• adj.

• 膜内の

関

intramembranous

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 常染色体優性多発性嚢胞腎の遺伝学および嚢胞成長のメカニズム genetics of autosomal dominant polycystic kidney disease and mechanisms of cyst growth

English Journal

• The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.

• Mosser S1, Alattia JR1, Dimitrov M1, Matz A1, Pascual J1, Schneider BL1, Fraering PC2.
• Human molecular genetics.Hum Mol Genet.2015 Jan 15;24(2):371-82. doi: 10.1093/hmg/ddu449. Epub 2014 Sep 1.
• The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an intramembrane-cleaving protease with multiple substrat
• PMID 25180020

• A Protease-Independent Function for SPPL3 in NFAT Activation.

• Makowski SL1, Wang Z1, Pomerantz JL2.
• Molecular and cellular biology.Mol Cell Biol.2015 Jan 15;35(2):451-67. doi: 10.1128/MCB.01124-14. Epub 2014 Nov 10.
• The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in innate or adaptive immunity by cleaving proteins involved in antigen presentation or intracellular signaling. Signal peptide peptidase-like 3 (
• PMID 25384971

• Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage.

• Takei N1, Sobu Y1, Kimura A1, Urano S1, Piao Y1, Araki Y1, Taru H1, Yamamoto T2, Hata S1, Nakaya T1, Suzuki T3.
• The Journal of biological chemistry.J Biol Chem.2015 Jan 9;290(2):987-95. doi: 10.1074/jbc.M114.599852. Epub 2014 Nov 18.
• The neural type I membrane protein Alcadein α (Alcα), is primarily cleaved by amyloid β-protein precursor (APP) α-secretase to generate a membrane-associated carboxyl-terminal fragment (Alcα CTF), which is further cleaved by γ-secretase to secrete p3-Alcα peptides and generate an intracellula
• PMID 25406318

Japanese Journal

• Alzheimer病予防・治療法におけるγセクレターゼ活性制御

• 神経治療学 33(3), 420-424, 2016
• NAID 130005279043

• Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage.

• eLife 4, 2015-10-08
• NAID 120005712942

• Hydrophilic microenvironment required for the channel-independent insertase function of YidC protein

• 2015-04-08
• NAID 120005716850

Related Links

• Long-term Report: Structural Study of Regulated ...

Introduction Proteolysis, as the name indicated, refers to the cleavage of protein in the presence of water. However, a new concept of proteolysis was coined in the last two decades, that is, the Regulated Intramembrane ...

• Long-term Report Structural Study of Regulated ...

SPring-8 利用者情報／2011年8月 198 最近の研究から intramembrane proteases. The breakthrough was finally made in 2006. Four independent groups successfully solved the structures of the bacterial homologs of Rhomboid in ...

---

★リンクテーブル★

リンク元	「膜内」「intramembranous」
拡張検索	「regulated intramembrane proteolysis」

「膜内」

　　[★]

英

intramembrane、intramembranous

「intramembranous」

　　[★]

• 膜内の

関

intramembrane

「regulated intramembrane proteolysis」

　　[★]

制御的膜内切断、制限的膜内切断

関

RIP