同: IDP

WordNet

a benign epithelial tumor forming a rounded mass (同)villoma, papillary_tumor, papillary tumour

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/20 09:07:38」(JST)

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Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in humans.^[1]

Two types of intraductal papillomas are generally distinguished. The central type develops near the nipple. They are usually solitary and often arise in the period nearing menopause. On the other hand, the peripheral type are often multiple papillomas arising at the peripheral breasts, and are usually found in younger women. The peripheral type are associated with a higher risk of malignancy.^[2]

They are the most common cause of bloody nipple discharge in women age 20-40 and generally do not show up on mammography due to their small size, so the next step in treatment would be a galactogram to guide the subsequent biopsy.

The masses are often too small to be palpated or felt. A galactogram is therefore necessary to rule out the lesion.

Excision is sometimes performed.^[3] Microdochectomy/microdochotomy (removal of a breast duct) is the treatment of choice.

Additional images

Histopathology of intraductal papilloma of the breast by excisional biopsy. Hematoxylin and eosin stain.
Histopathology of intraductal papilloma of the breast by excisional biopsy. Immunostaining for alpha-smooth muscle actin.

References

^ Cilotti A, Bagnolesi P, Napoli V, Lencioni R, Bartolozzi C (November 1991). "[Solitary intraductal papilloma of the breast. An echographic study of 12 cases]". La Radiologia Medica (in Italian) 82 (5): 617–20. PMID 1780459.
^ Tarallo, V; Canepari, E; Bortolotto, C (June 2012). "Intraductal papilloma of the breast: A case report.". Journal of ultrasound 15 (2): 99–101. doi:10.1016/j.jus.2012.03.002. PMID 23396758.
^ Ahmadiyeh N, Stoleru MA, Raza S, Lester SC, Golshan M (August 2009). "Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome". Ann. Surg. Oncol. 16 (8): 2264–9. doi:10.1245/s10434-009-0534-1. PMID 19484312.

UpToDate Contents

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1. 良性乳房疾患の概要 overview of benign breast disease
2. 乳頭分泌 nipple discharge
3. 小児および思春期における乳房腫瘤の概要 overview of breast masses in children and adolescents
4. 小児および思春期における乳房疾患の概要 overview of breast disorders in children and adolescents
5. 授乳および離乳の一般的問題 common problems of breastfeeding and weaning

English Journal

Diagnostic and therapeutic value of ductoscopy in nipple discharge and intraductal proliferations compared with standard methods.

Kamali S, Bender O, Kamali GH, Aydin MT, Karatepe O, Yuney E.SourceDepartment of Surgery, SB Okmeydani Training and Research Hospital, Istanbul, Turkey, kamalisedat@yahoo.com.
Breast cancer (Tokyo, Japan).Breast Cancer.2012 Jun 6. [Epub ahead of print]
BACKGROUND: Fiberoptic ductoscopy is a practical and direct approach that allows the visualization of intraductal breast disease. The aim of this study was to assess the efficacy of ductoscopy in the diagnosis and management of intraductal lesions.METHODS: Data on 357 ductoscopic investigations from
PMID 22669683

Current management practice of breast borderline lesions--need for further research and guidelines.

Nizri E, Schneebaum S, Klausner JM, Menes TS.SourceDepartment of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
American journal of surgery.Am J Surg.2012 Jun;203(6):721-5. Epub 2011 Dec 6.
BACKGROUND: Breast borderline lesions are usually diagnosed on needle biopsies of imaging abnormalities. The natural history of these lesions is unclear, and the literature is divided on appropriate management. It was hypothesized that management varies among surgeons and may be associated with surg
PMID 22153085

Japanese Journal

Biexponential Signal Attenuation Analysis of Diffusion-weighted Imaging of Breast

TAMURA Takayuki,USUI Shuji,MURAKAMI Shigeru,ARIHIRO Koji,AKIYAMA Yuji,NAITO Kumiko,AKIYAMA Mitoshi
Magnetic resonance in medical sciences : MRMS 9(4), 195-207, 2010-12-01
… Results: Decay of DWI signal of normal mammary glands, most cysts, and some fibroadenomas showed a monoexponential relationship, and conversely, that of intraductal papilloma (IDP) and malignant tumors was well fitted by a biexponential function. …
NAID 10027851481

Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma

TAJIMA Shinya,MAEDA Ichiro,KANEMAKI Yoshihide,NAKAJIMA Yasuo,TATSUNAMI Shinobu,FUKUDA Mamoru,TAKAGI Masayuki
Pathology international 60(6), 459-465, 2010-06-01
NAID 10029332209

Related Pictures

★リンクテーブル★

リンク元	「乳管内乳頭腫」
関連記事	「intraductal」

「乳管内乳頭腫」

Intraductal papilloma
	Histopathology of intraductal papilloma of the breast by excisional biopsy. Immunostaining for p63 protein.
Classification and external resources
ICD-O	M8503/0
DiseasesDB	31244
MedlinePlus	001238
MeSH	D018300