関: interpeduncular nuclei、nucleus interpeduncularis

WordNet

a part of the cell containing DNA and RNA and responsible for growth and reproduction (同)cell_nucleus, karyon
(astronomy) the center of the head of a comet; consists of small solid particles of ice and frozen gas that vaporizes on approaching the sun to form the coma and tail
any histologically identifiable mass of neural cell bodies in the brain or spinal cord
the positively charged dense center of an atom

PrepTutorEJDIC

中心,核 / (生物の)細胞核 / 原子核

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/18 20:57:09」(JST)

wiki en

The Interpeduncular nucleus is an unpaired, ovoid cell group at the base of the midbrain tegmentum. It is located in the mesencephalon below the interpeduncular fossa. As the name suggests, the interpeduncular nucleus lies in between the cerebral peduncles.

Composition

The Interpeduncular nucleus is primarily GABAergic and contains at least two neuron clusters of different morphologies. ^[1] The region is divided into 7 paired and unpaired subnuclei

Subdivisions

The presence of non-homologous subdivisions of the Interpeduncular nucleus was first noticed by Cajal over a hundred years ago.^[2] The currently recognized standard subdivision notation was mostly established by Hammill and Lenn in 1984 by combining the work and notations of four groups.^[3] Although most of their proposed convention stuck, at some point the proposed "rostral lateral" sub-nucleus was renamed "dorsomedial" and became immortalized in brain atlases.

Apical sub-nucleus (IPA)

Unpaired sub-nucleus. Former names include "caudal dorsal", "dorsal", and "pars dorsalis magnocellularis." ^[3]

Central sub-nucleus (IPC)

Unpaired sub-nucleus. Former names include: "rostral ventral", "caudal central", "posterior inter", and "pars medianus".^[3]

Dorsolateral sub-nucleus (IPDL)

Paired sub-nucleus.

Dorsomedial sub-nucleus (IPDM)

Paired sub-nucleus. Former names include: "rostral lateral"and "interstitial."^[3]

Intermediate sub-nucleus (IPI)

Paired sub-nucleus. Former names include: "caudal intermediate", "posterior inner" and "pars medianus."^[3]

Lateral sub-nucleus (IPL)

Paired sub-nucleus. Former names include: "caudal lateral", "paramedian" and "pars lateralis."^[3]

Rostral sub-nucleus (IPR)

Unpaired sub-nucleus. Former names include: "central" and "pars dorsalis."^[3]

Inputs

The major input to the IPN arrives via the fasciculus retroflex from the medial habenula. This pathway presents the IPN with several excitatory neurotransmitters including ACh and Substance P. Other brain regions that project to the Interpeduncular nucleus include: the Nucleus of diagonal band, the dorsal Tegmentum, the Raphe nuclei, the Central grey, and the Locus coeruleus.^[4]

Outputs

The major output pathways are inhibitory and project to the dorsal Tegmental area, the Periaqueductal gray and also the Raphe nuclei. In addition, output is sent to the following: the mediodorsal nucleus of the Thalamus, the lateral Habenula, the Septal nuclei, the anterior Mammillary nuclei, the Nucleus of diagonal band, the Preoptic area, the Ventral tegmental area, and in some species the dorsal and/or lateral Hypothalamus.^[4]

Function

The Interpeduncular nucleus is thought to have a broad inhibitory effects on many other brain regions. IPN activity is linked with decreased dopamine release and utilization from dopamine producing regions.^[5] The Interpeduncular nucleus is implicated with a role in the regulation of Rapid eye movement sleep ^[6] Activation of the GAD2 expressing sub-population of the IPN produced the physical symptoms of nicotine withdrawal suggesting that the misfunction of this region may be an active component of withdrawal.^[7]

References

^ Gioia, Magda (1994), A cluster analysis of the neurons of the rat interpeduncular nucleus, University of Milan, Italy: Wiley-Blackwell
^ Cajal, S.R. (1909,1911,1995). Histologie du Système Nerveux de l'Homme et des Vertébrés, L. Azoulay, trans. Paris: Maloine. Translated into English as Histology of the Nervous System of Man and Vertebrates. New York: Oxford University Press. Check date values in: |date= (help)
^ ^a ^b ^c ^d ^e ^f ^g Lenn, NJ; Hamill, GS (July 1984). "Subdivisions of the interpeduncular nucleus: a proposed nomenclature". Brain Research Bulletin. 13 (1): 203–4. doi:10.1016/0361-9230(84)90023-6. PMID 6478267.
^ ^a ^b Morley, BJ (1986). "The interpeduncular nucleus". International review of neurobiology. 28: 157–82. doi:10.1016/s0074-7742(08)60108-7. PMID 2433243.
^ Nishikawa, T; Fage, D; Scatton, B (May 14, 1986). "Evidence for, and nature of, the tonic inhibitory influence of habenulointerpeduncular pathways upon cerebral dopaminergic transmission in the rat". Brain Research. 373 (1–2): 324–36. doi:10.1016/0006-8993(86)90347-1. PMID 2424555.
^ Funato, Hiromasa (2010), Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep, University of Texas Southwestern Medical Center, Dallas: PNAS
^ Zhao-Shea, R; Liu, L; Pang, X; Gardner, PD; Tapper, AR (Nov 13, 2013). "Activation of GABAergic Neurons in the Interpeduncular Nucleus Triggers Physical Nicotine Withdrawal Symptoms". Current Biology. 23 (23): 2327–35. doi:10.1016/j.cub.2013.09.041. PMC 3855889 . PMID 24239118.

External links

Dictionary definition from Mondofacto.com

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 換気調節 control of ventilation
2. 頸部神経根障害の臨床的特徴および診断 clinical features and diagnosis of cervical radiculopathy
3. 成人における第三脳神経（動眼神経）麻痺 third cranial nerve oculomotor nerve palsy in adults
4. 小児における第3脳神経（動眼神経）麻痺 third cranial nerve oculomotor nerve palsy in children
5. パーキンソン病の外科治療 surgical treatment of parkinson disease

English Journal

Specific connections of the interpeduncular subnuclei reveal distinct components of the habenulopeduncular pathway.

Quina LA1, Harris J2, Zeng H2, Turner EE1,3.
The Journal of comparative neurology.J Comp Neurol.2017 Aug 15;525(12):2632-2656. doi: 10.1002/cne.24221. Epub 2017 May 30.
PMID 28387937

Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats.

Vincenz D1, Wernecke KEA2, Fendt M3, Goldschmidt J4.
Behavioural brain research.Behav Brain Res.2017 Aug 14;332:164-171. doi: 10.1016/j.bbr.2017.05.053. Epub 2017 May 26.
PMID 28552601

A Cooperative Mechanism Involving Ca2+-Permeable AMPA Receptors and Retrograde Activation of GABAB Receptors in Interpeduncular Nucleus Plasticity.

Koppensteiner P1, Melani R1, Ninan I2.
Cell reports.Cell Rep.2017 Aug 1;20(5):1111-1122. doi: 10.1016/j.celrep.2017.07.013.
PMID 28768196

Japanese Journal

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato Hiromasa,Sato Makito,Sinton Christopher M.,Gautron Laurent,Williams S. Clay,Skach Amber,Elmquist Joel K.,Skoultchi Arthur I.,Yanagisawa Masashi,柳沢正史
Proceedings of the National Academy of Sciences of the United States of America 107(42), 18155-18160, 2010-10
… The expression of Gscl is restricted to the interpeduncular nucleus (IP) in the ventral region of the midbrain–hindbrain transition. …
NAID 120002577309

Preconditioning with subneurotoxic allyl nitrile: Protection against allyl nitrile neurotoxicity

Tanii Hideji,Higashi T.,Saijoh Kiyofumi
Food and Chemical Toxicology 48(2), 750-754, 2010-02
… Compared with the 0 μmol/kg/day group, animals in the 200 and 400 μmol/kg/day pre-treatment groups exhibited decreased behavioral abnormalities and elevated GABA-positive cell counts in the substantia nigra pars reticulata and the interpeduncular nucleus. …
NAID 120001828362

Distribution of a brain-specific extracellular matrix protein in developing and adult zebrafish

Kanai Takahiro,Kajimoto Taketoshi,Nakayasu Hiroshi
Brain Research 1129(1), 53-62, 2007-1
… (4) The antigen is distributed only in limited areas of the brain, namely in the periphery of the forebrain, the hypothalamus, the optic tectum, the interpeduncular nucleus, the cerebellum and the ventricular rim of the medulla. …
NAID 120002311844

Related Pictures

★リンクテーブル★

リンク元	「脚間核」「interpeduncular nuclei」「nucleus interpeduncularis」
関連記事	「interpeduncular」

「脚間核」

Interpeduncular Nucleus
Details
Components	Apical subnucleus(IPA), Central subnucleus (IPC), Dorsolateral subnucleus (IPDL)x2, Dorsomedial subnucleus (IPDM)x2, Intermediate subnucleus (IPI)x2, Lateral subnculeus (IPL)x2, Rostral subnucleus(IPR)
Identifiers
Latin	Nucleus Interpeduncularis
MeSH	Interpeduncular+Nucleus
NeuroNames	hier-478
NeuroLex ID	Interpeduncular Nucleus
TA	A14.1.06.313
FMA	72439
	Anatomical terms of neuroanatomy [edit on Wikidata]