インターロイキン9受容体、インターロイキン9レセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

PrepTutorEJDIC

=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/29 13:37:58」(JST)

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Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.^[1]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

Interactions

Interleukin-9 receptor has been shown to interact with YWHAZ.^[2]

References

^ ^a ^b "Entrez Gene: IL9R interleukin 9 receptor".
^ Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. (ENGLAND). 345 Pt 3 (3): 741–7. doi:10.1042/0264-6021:3450741. ISSN 0264-6021. PMC 1220812. PMID 10642536.

External links

IL9R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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English Journal

IL-9 and its receptor are predominantly involved in the pathogenesis of UC.

Nalleweg N1, Chiriac MT2, Podstawa E1, Lehmann C3, Rau TT4, Atreya R1, Krauss E1, Hundorfean G1, Fichtner-Feigl S5, Hartmann A4, Becker C1, Mudter J6.
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OBJECTIVE: Several pathogenic roles attributed over the past two decades to either T helper (Th)1 or Th2 cells are increasingly becoming associated with interleukin (IL)-17 and most recently IL-9 signalling. However, the implication of IL-9 in IBD has not been addressed so far.DESIGN: We investigate
PMID 24957265

Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.

Åkesson K1, Tompa A, Rydén A, Faresjö M.
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Type 1 diabetes (T1D) and coeliac disease are both characterized by an autoimmune feature. As T1D and coeliac disease share the same risk genes, patients risk subsequently developing the other disease. This study aimed to investigate the expression of T helper (Th), T cytotoxic (Tc) and regulatory T
PMID 25421756

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT).

Jeitany M1, Pineda JR, Liu Q, Porreca RM, Hoffschir F, Desmaze C, Silvestre DC, Mailliet P, Junier MP, Londoño-Vallejo A, Ségal-Bendirdjian E, Chneiweiss H, Boussin FD.
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Glioblastoma multiforme is the most aggressive primary tumor of the central nervous system. Glioma stem cells (GSCs), a small population of tumor cells with stem-like properties, are supposedly responsible for glioblastoma multiforme relapse after current therapies. In approximately thirty percent o
PMID 25175359

Japanese Journal

House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

Allergology international : official journal of the Japanese Society of Allergology 57(2), 141-146, 2008-06-01
NAID 10021246553

House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

Allergology International 57(2), 141-146, 2008
NAID 130004476967

The Role of Interleukin-9 in Asthma

Allergology international : official journal of the Japanese Society of Allergology 54(1), 71-78, 2005-03-01
NAID 10014468709

「インターロイキン9受容体」

Interleukin 9 receptor
Identifiers
Symbols	IL9R ; CD129; IL-9R
External IDs	OMIM: 300007 MGI: 96564 HomoloGene: 37591 GeneCards: IL9R Gene
Gene ontology
Molecular function	• interleukin-9 receptor activity;
Cellular component	• extracellular space; • integral component of plasma membrane;
Biological process	• signal transduction; • cell proliferation; • interleukin-9-mediated signaling pathway; • positive regulation of protein targeting to mitochondrion;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;