- 関
- IL-7 receptor、IL7 receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/07 07:04:36」(JST)
[Wiki en表示]
IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green)
| Interleukin-7 receptor-α |
| Identifiers |
| Symbol |
IL7R |
| Alt. symbols |
CD127 |
| Entrez |
3575 |
| HUGO |
6024 |
| OMIM |
146661 |
| RefSeq |
NM_002185 |
| UniProt |
P16871 |
| Other data |
| Locus |
Chr. 5 p13 |
| interleukin 2 receptor, gamma |
|
| Identifiers |
| Symbol |
IL2RG |
| Alt. symbols |
SCIDX1, IMD4, CD132 |
| Entrez |
3561 |
| HUGO |
6010 |
| OMIM |
308380 |
| RefSeq |
NM_000206 |
| UniProt |
P31785 |
| Other data |
| Locus |
Chr. X q13 |
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[1][2] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Contents
- 1 Function
- 2 Diseases
- 3 See also
- 4 References
- 5 External links
Function[edit]
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation[citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[3]
Diseases[edit]
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[4] multiple sclerosis,[5] rheumatoid arthritis and juvenile idiopathic arthritis.[6]
See also[edit]
- Cluster of differentiation
References[edit]
- ^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077.
- ^ Kroemer RT, Richards WG (December 1996). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926.
- ^ "Entrez Gene: IL7R interleukin 7 receptor".
- ^ Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT (October 2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nat. Genet. 43 (10): 932–9. doi:10.1038/ng.924. PMID 21892159.
- ^ Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (September 2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet. 39 (9): 1083–91. doi:10.1038/ng2103. PMID 17660817.
- ^ O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (November 2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens 74 (5): 429–31. doi:10.1111/j.1399-0039.2009.01342.x. PMID 19744146.
External links[edit]
- IL7R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
|
| Other |
|
|
|
| TNF receptor |
| 1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
|
|
| 11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
|
|
| 21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
|
|
|
| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
|
| Other |
- hormone receptor: GH
- prolactin
|
|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
|
| IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
|
| S/T |
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
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English Journal
- T-cell homeostasis in chronic HCV-infected patients treated with interferon and ribavirin or an interferon-free regimen.
- Hartling HJ1,2, Birch C1,2, Gaardbo JC1,2, Hove M1,2, Trøseid M3, Clausen MR4, Gerstoft J1, Ullum H2, Nielsen SD1.
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.APMIS.2015 Oct;123(10):903-11. doi: 10.1111/apm.12429. Epub 2015 Aug 17.
- Direct-acting antiviral has replaced pegylated interferon-α and ribavirin-based treatment in the treatment of chronic hepatitis C virus (HCV) infection. While interferon-α is immune modulating and causes lymphopenia, interferon-free regimens seem to be well-tolerated. This study aimed to compare T
- PMID 26279289
- Decreased serum level of IL-7 in patients with active Graves' disease.
- Motylewska E1, Nieć M1, Siejka A2, Komorowski J2, Ławnicka H1, Świętosławski J3, Stępień H4.
- Cytokine.Cytokine.2015 Oct;75(2):373-9. doi: 10.1016/j.cyto.2015.04.020. Epub 2015 Jun 22.
- BACKGROUND: Graves' disease (GD) is a common autoimmune disease which is one of the major causes of hyperthyroidism. Interleukin 7 (IL-7) has been recently reported to play an important role in various autoimmune diseases, but its role in the pathogenesis of GD has not been assessed. The aim of this
- PMID 26113403
- IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice.
- Lee M1, Song SJ1, Choi MS2, Yu R3, Park T4.
- Diabetologia.Diabetologia.2015 Oct;58(10):2361-70. doi: 10.1007/s00125-015-3684-7. Epub 2015 Jul 8.
- AIM/HYPOTHESIS: Obesity-induced inflammation plays an important role in the development of insulin resistance and type 2 diabetes. Recent studies have demonstrated that adiposity can be improved by ablating certain inflammatory signalling pathways. Although the IL-7 receptor (IL-7R) is mostly known
- PMID 26152662
Japanese Journal
- Expression profiling of peripheral-blood mononuclear cells from patients with chronic hepatitis C undergoing interferon therapy
- Tateno Makoto,Honda Masao,Kawamura Takashi,Honda Hiroyuki,Kaneko Shuichi
- Journal of Infectious Diseases 195(2006), 255-267, 2007
- … early T cell-activation antigen CD69 was significantly up-regulated in patients with CH-C, but immune-related molecules such as chemokine (C-C motif) receptor 2 and interleukin 7 receptor were significantly down-regulated. …
- NAID 120003108676
- Interleukin-7 receptor expression on CD8 T-cells is down-regulated by the HIV Tat protein
- Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-effects of antiretroviral therapy
Related Links
- GoPubMed lists recent and important papers and reviews for interleukin 7 receptor(IL-7R) ... The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor ...
- Interleukin-7 (IL-7) acts primarily on T cells to promote their differentiation, survival, and homeostasis. Under disease conditions, IL-7 mediates inflammation through several mechanisms and cell types. In humans, IL-7 and its receptor ...
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★リンクテーブル★
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- IL7 receptor、interleukin-7 receptor
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- 英
- interleukin-7 receptor、IL-7 receptor
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