WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
any high mountain

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1. 心血管疾患と同等のリスクと確立した危険因子の概要 overview of the risk equivalents and established risk factors for cardiovascular disease
2. クローン病の内科的マネージメントにおける試験研究治療 investigational therapies in the medical management of crohn disease
3. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
4. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma
5. 喘息の遺伝学 genetics of asthma

The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.

Wu WL1, Adams CE2, Stevens KE3, Chow KH4, Freedman R3, Patterson PH4.
Brain, behavior, and immunity.Brain Behav Immun.2015 Feb 12. pii: S0889-1591(15)00023-9. doi: 10.1016/j.bbi.2015.02.005. [Epub ahead of print]
Mutation of human chromosome 15q13.3 increases the risk for autism and schizophrenia. One of the noteworthy genes in 15q13.3 is CHRNA7, which encodes the nicotinic acetylcholine receptor alpha 7 subunit (α7nAChR) associated with schizophrenia in clinical studies and rodent models. This study invest
PMID 25683697

IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.

Lee N1, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2014 Dec 15;190(12):1383-94. doi: 10.1164/rccm.201403-0601OC.
RATIONALE: Cytokine receptors can be markers defining different T-cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor α (IL-6Rα) with asthma was reported, suggesting their involvement in asthma.OBJECTIVES: To determine whether and how IL-6Rα defines a dis
PMID 25390970

One-week high-fat diet leads to reduced toll-like receptor 2 expression and function in young healthy men.

Wan Z1, Durrer C2, Mah D3, Simtchouk S4, Little JP5.
Nutrition research (New York, N.Y.).Nutr Res.2014 Dec;34(12):1045-51. doi: 10.1016/j.nutres.2014.08.012. Epub 2014 Sep 3.
Toll-like receptor 2 (TLR2) is implicated in inflammatory responses to high-fat diet (HFD)-induced obesity in rodents, but human HFD studies examining TLR2-mediated immune responses are lacking. Our aim was to determine whether HFD affected TLR2 function in humans. We hypothesized that a short-term
PMID 25245200

Chaetoglobosin Fex from the Marine-Derived Endophytic Fungus Inhibits Induction of Inflammatory Mediators via Toll-Like Receptor 4 Signaling in Macrophages

Recombinant soluble form of the high-affinity IgE receptor .ALPHA. subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways.