WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/15 07:22:10」(JST)

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The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Function

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.^[1]

The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages (AAMΦ) downregulate inflammatory mediators such as IFNγ during immune responses, particularly with regards to helminth infections.^[2]

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.^[3]^[4]

Structure

The N-terminal (extracellular) portion of interleukin-4 receptor is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.^[5]

References

^ "Entrez Gene: IL4R interleukin 4 receptor".
^ Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y. Acad. Sci. 1253: E1–E13. doi:10.1111/j.1749-6632.2012.06618.x. PMID 22974465.
^ Ikizawa K, Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. PMID 10652211.
^ Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. 167 (11): 6382–7. doi:10.4049/jimmunol.167.11.6382. PMID 11714803.
^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.

External links

CD124 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the public domain Pfam and InterPro IPR015319

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 喘息の遺伝学 genetics of asthma
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
4. 複合免疫不全 combined immunodeficiencies
5. 肥満細胞由来のメディエーター mast cell derived mediators

English Journal

Role and regulation of VEGF and its receptors 1 and 2 in the aseptic loosening of total hip implants.

Waris V, Sillat T, Waris E, Virkki L, Mandelin J, Takagi M, Konttinen YT.SourceMikkeli Central Hospital, 50100 Mikkeli, Finland; Department of Anatomy, Institute of Biomedicine, Biomedicum, University of Helsinki, 00014 Helsinki, Finland.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.J Orthop Res.2012 Nov;30(11):1830-6. doi: 10.1002/jor.22138. Epub 2012 Apr 23.
It was hypothesized that vascular endothelial growth factor (VEGF) in fibroblasts participates in aseptic loosening of total hip replacement (THR) implants. Therefore, osteoarthritic (OA) samples (n = 11) were compared with synovial membrane-like interface tissues from revision THR (n = 10).
PMID 22528855

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC.Source1] Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. [2] School of Medicine, University of Tampere, Tampere, Finland. [3] Fimlab Laboratories, Tampere, Finland. [4].
Nature chemical biology.Nat Chem Biol.2012 Oct 28. doi: 10.1038/nchembio.1096. [Epub ahead of print]
Cytokines dimerize their receptors, with the binding of the 'second chain' triggering signaling. In the interleukin (IL)-4 and IL-13 system, different cell types express varying numbers of alternative second receptor chains (γc or IL-13Rα1), forming functionally distinct type I or type II complexe
PMID 23103943

Japanese Journal

Association of mast cell-derived VEGF and proteases in dengue shock syndrome

Furuta Takahisa,Murao Lyre Anni,Lan Nguyen Thi Phuong,Huy Nguyen Tien,Huong Vu Thi Que,Thuy Tran Thi,Tham Vo Dinh,Nga Cao Thi Phi,Ha Tran Thi Ngoc,Ohmoto Yasukazu,Kikuchi Mihoko,Morita Kouichi,Yasunami Michio,Hirayama Kenji,Watanabe Naohiro
PLoS Neglected Tropical Diseases 6(2), e1505, 2012-02-21
… To clarify the role of mast cells in the development of clinical Dengue fever, we compared the plasma levels of several mast cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) and -related cytokines (IL-4, -9, and -17) between patients with differing severity of Dengue fever and healthy controls. … By day 4 of admission, VEGF, sVEGFRs, and proteases levels had returned to similar levels as DF and controls. …
NAID 120004442177

Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.

Shindo Hisakazu,Yasui Kiyoshi,Yamamoto Kazuo,Honma Kiri,Yui Katsuyuki,Kohno Tomoko,Ma Yuhua,Chua Koon Jiew,Kubo Yoshinao,Aihara Hitoshi,Ito Takashi,Nagayasu Takeshi,Matsuyama Toshifumi,Hayashi Hideki
Cytokine 56(3), 564-572, 2011-12
… Interferon regulatory factor (IRF)-4 is a member of the IRF transcription factor family, whose expression is primarily restricted to lymphoid and myeloid cells. … In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells. …
NAID 120003659758

Related Pictures

★リンクテーブル★

リンク元	「IL-4 receptor」「インターロイキン4受容体」「インターロイキン4レセプター」
拡張検索	「type II interleukin-4 receptor」「type I interleukin-4 receptor」「interleukin-4 receptor alpha subunit」
関連記事	「interleukin」「interleukins」

「IL-4 receptor」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interleukin-4 receptor alpha chain, N-terminal
	interleukin-4 / receptor alpha chain complex
Identifiers
Symbol	IL4Ra_N
Pfam	PF09238
InterPro	IPR015319
SCOP	1iar
SUPERFAMILY	1iar
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interleukin 4 receptor
	; PDB rendering based on 1iar.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IAR, 1IRS, 1ITE, 3BPL, 3BPN, 3BPO
Identifiers
Symbols	IL4R ; CD124; IL-4RA; IL4RA
External IDs	OMIM: 147781 MGI: 105367 HomoloGene: 7784 IUPHAR: 1697 GeneCards: IL4R Gene
Gene ontology
Molecular function	• interleukin-4 receptor activity; • receptor signaling protein activity; • protein binding; • insulin receptor substrate binding;
Cellular component	• extracellular space; • integral component of plasma membrane; • receptor complex;
Biological process	• production of molecular mediator involved in inflammatory response; • immune response; • signal transduction; • ovulation; • intracellular signal transduction; • interleukin-4-mediated signaling pathway; • regulation of cell proliferation; • defense response to protozoan; • positive regulation of macrophage activation; • response to estrogen; • negative regulation of T-helper 1 cell differentiation; • positive regulation of T-helper 2 cell differentiation; • positive regulation of chemokine secretion;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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