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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/11 17:07:24」(JST)

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  • Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts.
  • Glim JE, Niessen FB, Everts V, van Egmond M, Beelen RH.SourceDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands; Department of Plastic and Reconstructive Surgery, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:
  • Immunobiology.Immunobiology.2013 Jun;218(6):924-9. doi: 10.1016/j.imbio.2012.10.004. Epub 2012 Oct 26.
  • Dermal wounds can heal detrimentally by formation of excess fibrosis or hypertrophic scarring. These phenomena are normally absent in the oral mucosa. Macrophages play an important role in wound repair, have a marked heterogeneity and are thought to contribute to fibrosis. To investigate to what ext
  • PMID 23182716
  • Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.
  • Olver S, Apte SH, Baz A, Kelso A, Kienzle N.SourceThe Cooperative Research Centre for Vaccine Technology and the Queensland Institute of Medical Research, Herston, Qld, Australia.
  • Immunology.Immunology.2013 Jun;139(2):187-96. doi: 10.1111/imm.12068.
  • Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) pheno
  • PMID 23311920


  • A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovitis.
  • Kobayashi Shio,Murata Koichi,Shibuya Hideyuki,Morita Mami,Ishikawa Masahiro,Furu Moritoshi,Ito Hiromu,Ito Juichi,Matsuda Shuichi,Watanabe Takeshi,Yoshitomi Hiroyuki
  • Arthritis and rheumatism, 2013-09-10
  • … 2013-09-20.[Objective] ]Human CD4+ T cells in synovitis of rheumatoid arthritis (RA) produce CXCL13, a chemokine crucial for the formation of germinal center. … [Methods] The expression of Th markers and CXCL13 in CD4+ T cells of RA synovitis and the involvement of proinflammatory cytokines in CXCL13 production were assessed. … We also investigated whether CXCL13+CD4+ T cells could be newly induced. …
  • NAID 120005327027
  • Mast Cell Stabilizing Effect of (-)‐Elema‐1,3,11(13)‐trien‐12‐ol and Thujopsene from Thujopsis dolabrata Is Mediated by Down‐Regulation of Interleukin4 Secretion in Antigen‐Induced RBL‐2H3 Cells
  • Kim Chul-Hee,Lee Taehun,Oh Ikhoon [他]
  • Biological & pharmaceutical bulletin 36(3), 339-345, 2013-03-00
  • NAID 40019588153
  • Effect of Eriodictyol on the Development of Atopic Dermatitis-Like Lesions in ICR Mice
  • Park Sae-Jin,Lee Yong-Hyeon,Lee Kwang Ho,Kim Tack-Joong
  • Biological and Pharmaceutical Bulletin 36(8), 1375-1379, 2013
  • … Our previous studies have reported that eriodictyol extract inhibits immunoglobulin E (IgE)/Ag-induced type I hypersensitivity by suppressing the activation of proinflammatory cytokines, such as interleukin-4 (IL-4), and the expression of ceramide kinase. … In this study, we investigated the inhibitory effect of eriodictyol on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in ICR mice. …
  • NAID 130003361497


^Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. (2008). "A mechanism for the initiation of allergen-induced T helper type 2 responses". Nat Immunol 9 (3): 310–318. doi:10.1038/ni1558. PMID 18300366. ^ Hershey GK ...
解説:小粒子LDLプロファイル(Small,Dense LDL Profile) ... インターロイキン-4(Interleukin-4:IL-4) インターロイキン-4(IL-4)は、主にヘルパーT細胞より産生され、T細胞・B細胞および他の血球細胞に広汎な生理活性を有する ...


FIGURE 4 | Early events in susceptible and Interleukin-4 receptor signaling pathways Interleukin 4Interleukin-4 receptorDownload figureInterleukin-4

拡張検索interleukin-4 receptor」「type II interleukin-4 receptor」「type I interleukin-4 receptor」「interleukin-4 receptor alpha subunit



interleukin-4, interleukin 4


  • B細胞のIgのクラススイッチを促進(SP.251) ← IgEへのクラススイッチ



  • B細胞活性化、IgEスイッチ、Th2細胞への分化誘導


interleukin-4 receptor」


IL-4 receptor、IL4 receptor

type II interleukin-4 receptor」


type I interleukin-4 receptor」


interleukin-4 receptor alpha subunit」



  [★] インターロイキン IL

WordNet   license wordnet

「any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system」


  [★] インターロイキン IL