WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
any high mountain

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The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3.

Zhang Y1, Liu R2, Fan D1, Shi R3, Yang M1, Miao Q4, Deng ZQ5, Qian J5, Zhen Y4, Xiong D1, Wang J1.
Cancer biology & therapy.Cancer Biol Ther.2015 Oct;16(10):1514-25. doi: 10.1080/15384047.2015.1071733. Epub 2015 Jul 17.
CD123 became a therapeutic target for acute myelocytic leukemia(AML) because of its overexpression only on AML stem cells. It is α subunit of interleukin-3 (multi-CSF, IL3) receptor. Lidamycin(LDM) is a novel antibiotic composed of an apoprotein (LDP) and a chromophore (AE). We cloned, expressed an
PMID 26186454

Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.

Falini B1, Sportoletti P1, Brunetti L1, Martelli MP1.
British journal of haematology.Br J Haematol.2015 Aug;170(3):305-22. doi: 10.1111/bjh.13409. Epub 2015 Apr 19.
The acute myeloid leukaemia (AML) genome contains more than 20 driver recurrent mutations. Here, we review the potential for therapeutic targeting of the most common mutations associated with normal cytogenetics AML, focusing on those affecting the FLT3, NPM1 and epigenetic modifier genes (DNMT3A, I
PMID 25891481

Broughton SE1, Nero TL2, Dhagat U2, Kan WL3, Hercus TR3, Tvorogov D3, Lopez AF3, Parker MW4.
Cytokine.Cytokine.2015 Aug;74(2):247-58. doi: 10.1016/j.cyto.2015.02.005. Epub 2015 May 14.
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc). These cytokines regulate the growth, differentiation, migration and effector function activities of many hematopoietic cells i
PMID 25982846