WordNet

any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/24 18:28:34」(JST)

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Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene.^[1]^[2]

Function

Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor.

Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. Activated T cells can either induce their own proliferation and differentiation (autocrine signalling), or that of other T cells (paracrine signalling) - both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage-secreted IL-1). The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

Discovery

Interleukin 3 originally was discovered by JN Ihle in mice. He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3.^[3]^[4]

Interactions

Interleukin 3 has been shown to interact with IL3RA.^[5]^[6]

References

^ "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)".
^ Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530.
^ Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J. Immunol. 126 (6): 2184–9. PMID 6971890.
^ Ihle JN, Weinstein Y, Keller J, Henderson L, Palaszynski E (1985). "Interleukin 3". Meth. Enzymol. Methods in Enzymology 116: 540–52. doi:10.1016/S0076-6879(85)16042-8. ISBN 978-0-12-182016-9. PMID 3003517.
^ Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. PMC 231298. PMID 8649415.
^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. PMC 395466. PMID 7957082.

UpToDate Contents

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5. 骨髄造血の制御 regulation of myelopoiesis

English Journal

Beetroot (Beta vulgaris) rescues mice from γ-ray irradiation by accelerating hematopoiesis and curtailing immunosuppression.

Cho J1, Bing SJ1, Kim A2, Lee NH3, Byeon SH3, Kim GO4, Jee Y1.
Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):306-319.
PMID 27927068

Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells.

López C1, Zamorano P1, Teuber S1, Salas M1, Otth C2,3, Hidalgo MA4, Concha I1, Zambrano A1,3.
Journal of cellular biochemistry.J Cell Biochem.2017 Jun;118(6):1330-1340. doi: 10.1002/jcb.25790. Epub 2017 Jan 10.
PMID 27862234

A Chemically Inducible Helper Module for Detecting Protein-Protein Interactions with Tunable Sensitivity Based on KIPPIS.

Kashima D1, Kawade R1, Nagamune T1, Kawahara M1.
Analytical chemistry.Anal Chem.2017 Apr 13. doi: 10.1021/acs.analchem.6b04063. [Epub ahead of print]
PMID 28382822

Japanese Journal

Constitutive exposure of phosphatidylserine on viable cells.

Segawa Katsumori,Suzuki Jun,Nagata Shigekazu
Proceedings of the National Academy of Sciences of the United States of America 108(48), 19246-19251, 2011-11-29
… They efficiently responded to interleukin 3 and underwent apoptosis upon treatment with Fas ligand. …
NAID 120003674044

インターロイキン3(IL-3),IL-4,IL-5 (広範囲血液・尿化学検査免疫学的検査(第7版・4)その数値をどう読むか) -- (プロスタノイド,サイトカイン,増殖因子,ケモカイン)

新納宏昭
日本臨床 68(-) (982), 72-74, 2010-07
NAID 40017200690

The Effects of X-Irradiation on Ex Vivo Expansion of Cryopreserved Human Hematopoietic Stem/Progenitor Cells

Hayashi Naoki,Takahashi Kenji,Kashiwakura Ikuo
Journal of radiation research 51(2), 137-144, 2010-03-16
… After cryopreservation with the optimal procedure, 2 Gy-irradiated HSPCs were cultured with or without stromal cells supplemented with combination of interleukin-3, stem cell factor, and thrombopoietin. …
NAID 10025914531

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★リンクテーブル★

リンク元	「IL-3」
拡張検索	「interleukin-3 receptor」「interleukin-3 receptor alpha subunit」
関連記事	「interleukin」「interleukins」

「IL-3」

IL3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1JLI
Identifiers
Aliases	IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
External IDs	OMIM: 147740 HomoloGene: 47938 GeneCards: 3562
Gene ontology
Molecular function	• growth factor activity; • interleukin-3 receptor binding; • cytokine activity;
Cellular component	• extracellular region; • intracellular; • extracellular space;
Biological process	• positive regulation of DNA replication; • activation of MAPKK activity; • MAPK cascade; • embryonic hemopoiesis; • epidermal growth factor receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • neurotrophin TRK receptor signaling pathway; • insulin receptor signaling pathway; • axon guidance; • cell-cell signaling; • positive regulation of myeloid leukocyte differentiation; • vascular endothelial growth factor receptor signaling pathway; • small GTPase mediated signal transduction; • Fc-epsilon receptor signaling pathway; • nervous system development; • positive regulation of tyrosine phosphorylation of Stat5 protein; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of mast cell proliferation; • cytokine-mediated signaling pathway; • innate immune response; • Ras protein signal transduction; • immune response; • positive regulation of cell proliferation;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	3562
	n/a
	ENSG00000164399
	n/a
	P08700
	n/a
	NM_000588
	n/a
	NP_000579.2
	n/a
	Wikidata
View/Edit Human