WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
any high mountain

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Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.

Liu H, Irwanto A, Tian H, Fu X, Yu Y, Yu G, Low H, Chu T, Li Y, Shi B, Chen M, Sun Y, Yuan C, Lu N, You J, Bao F, Li J, Liu J, Liu H, Liu D, Yu X, Zhang L, Yang Q, Wang N, Niu G, Ma S, Zhou Y, Wang C, Chen S, Zhang X, Liu J, Zhang F.SourceShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
American journal of human genetics.Am J Hum Genet.2012 Nov 2;91(5):935-41. doi: 10.1016/j.ajhg.2012.09.010. Epub 2012 Oct 25.
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susce
PMID 23103228

Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.

Havenith SH, Yong SL, Henson SM, Piet B, Idu MM, Koch SD, Jonkers RE, Kragten NA, Akbar AN, van Lier RA, ten Berge IJ.SourceRenal Transplant Unit, Department of Internal Medicine, Academic Medical Center Amsterdam, The Netherlands. s.h.havenith@amc.uva.nl
International immunology.Int Immunol.2012 Oct;24(10):625-36. Epub 2012 Jul 26.
CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the
PMID 22836020

Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden.

Vidal F, Domingo P, Villarroya F, Giralt M, López-Dupla M, Gutiérrez M, Gallego-Escuredo JM, Peraire J, Viladés C, Veloso S, Mateo G, Guallar JP, Richart C.SourceDepartment of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain. fvidalmarsal.hj23.ics@gencat.cat
Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2012 Oct 1;61(2):131-7.
BACKGROUND: HIV-1 can induce disturbances in adipose tissue in infected subjects through the effects of some of its proteins or inflammation. It is not known whether this also takes place in HIV-1-infected long-term nonprogressors (LTNPs). Our objectives were to determine whether adipocyte different
PMID 22580565