関: IL-14

WordNet

any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/20 16:58:47」(JST)

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Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.^[1]^[2]^[3]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.^[4] This molecule was also recently designated taxilin.^[5] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.^[6] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.
^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251.
^ "Entrez Gene: TXLNA taxilin alpha".
^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514.
^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796.
^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757.

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English Journal

Central role for marginal zone B cells in an animal model of Sjogren's syndrome.

Shen L1, Gao C2, Suresh L3, Xian Z4, Song N4, Chaves LD1, Yu M1, Ambrus JL Jr5.
Clinical immunology (Orlando, Fla.).Clin Immunol.2016 Jul;168:30-6. doi: 10.1016/j.clim.2016.04.008. Epub 2016 Apr 30.
Patients with Sjogren's syndrome (SS) have been shown to have abnormal B cell function and increased numbers of marginal zone B cells (MZB and MZB precursors. The current studies utilized the Interleukin 14 alpha transgenic mouse model (IL14aTG) for SS to investigate the roles of marginal zone B cel
PMID 27140729

Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation.

Bodine BG1, Bennion BG2, Leatham E3, Jimenez FR4, Wright AJ5, Jergensen ZR6, Erickson CJ7, Jones CM8, Johnson JP9, Knapp SM10, Reynolds PR11.
Respiratory research.Respir Res.2014 Oct 29;15:133. doi: 10.1186/s12931-014-0133-y.
BACKGROUND: Receptors for advanced glycation end-products (RAGE) are multiligand cell-surface receptors expressed abundantly by distal pulmonary epithelium. Our lab has discovered RAGE-mediated effects in the orchestration of lung inflammation induced by tobacco smoke and environmental pollutants; h
PMID 25359169

Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome.

Xuan J1, Shen L, Malyavantham K, Pankewycz O, Ambrus JL Jr, Suresh L.
BMC oral health.BMC Oral Health.2013 Oct 5;13:51. doi: 10.1186/1472-6831-13-51.
BACKGROUND: Evidence in imaging studies suggests that there may be differences in glandular involvement in Sjogren's syndrome (SS) depending on the stage of the disease. No detailed histological studies are available to show if there are any such difference in glandular involvement at various time p
PMID 24093879

Related Pictures

★リンクテーブル★

リンク元	「インターロイキン14」「インターロイキン-14」「IL-14」
関連記事	「interleukin」「interleukins」

「インターロイキン14」

taxilin alpha
Identifiers
Aliases	TXLNA, IL14, TXLN
External IDs	MGI: 105968 HomoloGene: 14062 GeneCards: 200081
Gene ontology
Molecular function	• cytokine activity; • syntaxin binding; • protein binding; • high molecular weight B cell growth factor receptor binding;
Cellular component	• cytoplasm; • extracellular region; • membrane;
Biological process	• B cell activation; • mitophagy in response to mitochondrial depolarization; • cell proliferation; • exocytosis;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	200081
	109658
	ENSG00000084652
	ENSMUSG00000053841
	P40222
	Q6PAM1
	NM_175852
	NM_001005506; NM_001199695
	NP_787048.1
	NP_001005506.2; NP_001186624.1
	Wikidata
View/Edit Human	View/Edit Mouse