WordNet

any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

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1. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
2. リウマチ性疾患のマネージメントに用いる生物学的製剤とキナーゼ阻害薬の概要 overview of biologic agents and kinase inhibitors in the rheumatic diseases
3. 乾癬の病態生理 pathophysiology of psoriasis
4. Investigational therapies in the medical management of Crohn disease
5. 炎症性腸疾患の病因における免疫および微生物学的機序 immune and microbial mechanisms in the pathogenesis of inflammatory bowel disease

English Journal

SV40 Infection of Mesenchymal Stromal Cells From Wharton's Jelly Drives the Production of Inflammatory and Tumoral Mediators.

Cason C1,2, Campisciano G2, Zanotta N1, Valencic E1, Delbue S3, Bella R3, Comar M1,2.
Journal of cellular physiology.J Cell Physiol.2017 Nov;232(11):3060-3066. doi: 10.1002/jcp.25723. Epub 2016 Dec 29.
PMID 27925194

[Inhibitory effect of bispecific antibody targeting IL-12 p40 and TNF-α simultaneously on psoriasis in mice].

Xu P1, Xie N2, Ye C3.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.2017 Jul;33(7):890-895.
PMID 28712395

Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/Macrophages.

Cui B1, Liu W2, Wang X1, Chen Y1, Du Q1, Zhao X1, Zhang H3, Liu SL4, Tong D1, Huang Y1.
Frontiers in immunology.Front Immunol.2017 Jun 26;8:708. doi: 10.3389/fimmu.2017.00708. eCollection 2017.
PMID 28694807

Japanese Journal

Circulating IL-12 p40 is Increased in The Patients with Sarcoidosis, Correlation with Clinical Markers

Internal Medicine 46(17), 1387-1394, 2007
NAID 130000076059

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

Endocrine Journal 53(6), 753-759, 2006
NAID 130004443265

Lack of Association between IL-12B Gene Polymorphism and Autoimmune Thyroid Disease in Japanese Patients

Endocrine journal 51(6), 609-613, 2004-12-01
NAID 10014080667

Related Links

The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization ...

IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 biosynthesis at the posttranscriptional and ...

The p40 subunit of interleukin (IL)-12 promotes stabilization ...

1. J Biol Chem. 2013 Mar 1;288(9):6763-76. doi: 10.1074/jbc.M112.436675. Epub 2013 Jan 7. The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 ...