WordNet

any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

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1. 乾癬の病態生理 pathophysiology of psoriasis
2. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
3. 炎症性腸疾患の病因における免疫および微生物学的機序 immune and microbial mechanisms in the pathogenesis of inflammatory bowel disease
4. クローン病の内科的マネージメントにおける試験研究治療 investigational therapies in the medical management of crohn disease
5. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus

Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women.

Nikołajuk A1, Karczewska-Kupczewska M1,2, Straczkowski M1,2.
Metabolic syndrome and related disorders.Metab Syndr Relat Disord.2015 Jun 3. [Epub ahead of print]
BACKGROUND: Obesity is a chronic low-grade inflammatory state associated with the development of insulin resistance, type 2 diabetes mellitus, and atherosclerosis. Interleukin-12 (IL-12) is a proinflammatory cytokine composed of a 40-kD (p40) subunit and a 35-kD (p35) subunit. p40 might have an inde
PMID 26038987

Characterization of an IL-12 p40/p35 Truncated Fusion Protein That Can Inhibit the Action of IL-12.

Skrombolas D1, Wylie I, Maharaj S, Frelinger JG.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.J Interferon Cytokine Res.2015 May 4. [Epub ahead of print]
Interleukin-12 (IL-12), a potent inducer of interferon gamma (IFNγ), is a heterodimeric protein consisting of p40 and p35 subunits whose expression is regulated independently. IL-12 is part of a cytokine family (currently consisting of IL-12, IL-23, IL-27, and IL-35) that can have profoundly differ
PMID 25938719

IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection.

Heim CE1, Vidlak D1, Scherr TD1, Hartman CW2, Garvin KL2, Kielian T3.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Apr 15;194(8):3861-72. doi: 10.4049/jimmunol.1402689. Epub 2015 Mar 11.
Staphylococcus aureus is a leading cause of human prosthetic joint infections (PJIs) typified by biofilm formation. We recently identified a critical role for myeloid-derived suppressor cells (MDSCs) in S. aureus biofilm persistence. Proinflammatory signals induce MDSC recruitment and activation in
PMID 25762781

Circulating IL-12 p40 is Increased in The Patients with Sarcoidosis, Correlation with Clinical Markers

Hata Masahiro,Sugisaki Katsunori,Miyazaki Eishi,Kumamoto Toshihide,Tsuda Tomiyasu
Internal Medicine 46(17), 1387-1394, 2007
… Because interleukin 12 (IL-12) is one of the most important cytokines for promoting Th1 reaction, we tried to detect IL-12 and its ligand IL-12 receptor in sarcoidosis patients. …
NAID 130000076059

今村隆幸,今村孝,前田浩明 [他],江田康幸,時吉幸男,安部眞一,見上彪
The journal of veterinary medical science 62(10), 1079-1087, 2000-10-25
… 猫IL12p35, p40cDNA全長遺伝子のクローニングおよび動物細胞を宿主とした系での発現をおこない, その生物活性を確認した.さらに, p35cDNA遺伝子を改変することで, 生物活性を有する猫IL12の発現量が約100倍上昇した.猫脾臓細胞よりcDNAライブラリーを作成し, ヒトIL12p35, p40cDNAをプローブとして, このcDNAライブラリーのスクリーニングを行った.得られた …
NAID 110003920531