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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/27 19:17:37」(JST)

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  • A multifunctional streptococcal collagen-mimetic protein coating prevents bacterial adhesion and promotes osteoid formation on titanium.
  • Bronk JK1, Russell BH2, Rivera JJ2, Pasqualini R3, Arap W3, Höök M4, Barbu EM5.
  • Acta biomaterialia.Acta Biomater.2014 Jul;10(7):3354-62. doi: 10.1016/j.actbio.2014.04.005. Epub 2014 Apr 13.
  • The major barriers to the clinical success of orthopedic and dental implants are poor integration of fixtures with bone tissue and biomaterial-associated infections. Although multifunctional device coatings have long been considered a promising strategy, their development is hindered by difficulties
  • PMID 24732634
  • The PDZ-binding domain of syndecan-2 inhibits LFA-1 high-affinity conformation.
  • Rovira-Clavé X1, Angulo-Ibáñez M2, Reina M3, Espel E4.
  • Cellular signalling.Cell Signal.2014 Jul;26(7):1489-99. doi: 10.1016/j.cellsig.2014.03.012. Epub 2014 Mar 21.
  • Syndecans are cell membrane proteoglycans that can modulate the activity and dynamics of some growth factor receptors and integrins. Here, we show the down-regulation of integrin lymphocyte function-associated antigen-1 (LFA-1) and inhibition of adhesion of Jurkat T cells transfected with syndecan-2
  • PMID 24662262
  • Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury.
  • Almolda B1, Villacampa N, Manders P, Hidalgo J, Campbell IL, González B, Castellano B.
  • Glia.Glia.2014 Jul;62(7):1142-61. doi: 10.1002/glia.22668. Epub 2014 Apr 2.
  • Interleukin-6 (IL-6) is a pleiotropic cytokine with a key role in the control of inflammatory/immune responses. In the central nervous system (CNS), an increase in IL-6 occurs in a wide range of pathological conditions such as excitotoxicity and traumatic brain injury. We evaluated the effects of as
  • PMID 24691898


  • Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy
  • Kinoshita Rumiko,Nam Jin-Min,Ito Yoichi M.,Hatanaka Kanako C.,Hashimoto Ari,Handa Haruka,Otsuka Yutaro,Hashimoto Shigeru,Onodera Yasuhito,Hosoda Mitsuchika,Onodera Shunsuke,Shimizu Shinichi,Tanaka Shinya,Shirato Hiroki,Tanino Mishie,Sabe Hisataka
  • Plos one 8(10), e76791, 2013-10-07
  • … This pathway activates beta 1 integrins and perturbs E-cadherin-based adhesions, hence appears to be integral for epithelial-mesenchymal transdifferentiation (EMT). …
  • NAID 120005348196
  • インテグリンを標的とした骨形成および骨修復の促進
  • Marie Pierre J.
  • Nature reviews. Endocrinology 6(2), 60-67, 2013-10
  • NAID 40019845179
  • Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models
  • Onishi Manabu,Ichikawa Tomotsugu,Kurozumi Kazuhiko,Fujii Kentaro,Yoshida Koichi,Inoue Satoshi,Michiue Hiroyuki,Chiocca E. Antonio,Kaur Balveen,Date Isao
  • Neuropathology 33(2), 162-174, 2013-04
  • Integrins are expressed in tumor cells and tumor endothelial cells, and likely play important roles in glioma angiogenesis and invasion. …
  • NAID 120005311964


When integrins were being identified with antibodies to integrin β subunits, several proteins were co-immunoprecipitated, and the number of subunits that composed the functional receptors was by no means obvious.
The binding of integrins to their ligands depends on extracellular divalent cations (Ca 2+ or Mg 2+, depending on the integrin), reflecting the presence of divalent-cation-binding domains in the extracellular part of the α and β subunits.
Enter Site


Integrins are important adhesion molecules IntegrinsIntegrins during evolutionIntegrinsIntegrins in cell migration – the actin Integrins




integrin, integrins

インテグリン IMM.87

name tissue distribution ligand
単球 T細胞 マクロファージ 好中球 樹状細胞
αL:β2 LFA-1 CD11a:CD18 ICAMs
αM:β2 CR3, Mac-1 CD11b:CD18     ICAM-1, iC3b, fibrinogen
αx:β2 CR4, p150.90 CD11c:CD18     iC3b
α5:β1 VLA-5 CD49d:CD29       fibronectin


  [★] インテグリン