UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Laminins 411 and 421 differentially promote tumor cell migration via α6β1 integrin and MCAM (CD146).

Ishikawa T1, Wondimu Z1, Oikawa Y1, Gentilcore G2, Kiessling R2, Egyhazi Brage S2, Hansson J2, Patarroyo M3.
Matrix biology : journal of the International Society for Matrix Biology.Matrix Biol.2014 Jun 18. pii: S0945-053X(14)00095-X. doi: 10.1016/j.matbio.2014.06.002. [Epub ahead of print]
α4-laminins, such as laminins 411 and 421, are mesenchymal laminins expressed by blood and lymphatic vessels and some tumor cells. Laminin-411 promotes migration of leukocytes and endothelial cells, but the effect of this laminin and laminin-421 on tumor cells is poorly understood. In the present s
PMID 24951930

NFAT2 regulates COX-2 expression and modulates the integrin repertoire in endothelial cells at the crossroads of angiogenesis and inflammation.

Mena MP1, Papiewska-Pajak I2, Przygodzka P1, Kozaczuk A1, Boncela J1, Cierniewski CS3.
Experimental cell research.Exp Cell Res.2014 Jun 10;324(2):124-36. doi: 10.1016/j.yexcr.2014.03.008. Epub 2014 Mar 18.
The mechanisms controlling the switch between the pro-angiogenic and pro-inflammatory states of endothelial cells are still poorly understood. In this paper, we show that: (a) COX-2 expression induced by VEGF-A is NFAT2-dependent; and (b) the integrin profile in endothelial cells induced by the pro-
PMID 24657343

CCN1 enables Fas ligand-induced apoptosis in cardiomyoblast H9c2 cells by disrupting caspase inhibitor XIAP.

Su BC1, Mo FE2.
Cellular signalling.Cell Signal.2014 Jun;26(6):1326-34. doi: 10.1016/j.cellsig.2014.02.019. Epub 2014 Mar 12.
Cell proliferation from pre-existing cardiomyocytes is a major source of cells for normal mammalian myocardial renewal or for regeneration after myocardial injury. These proliferative cardiomyocytes may act differently from the postmitotic cardiomyocytes in a stressed heart. Extracellular matrix mol
PMID 24631528

Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells