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English Journal

SAHA triggered MET activation contributes to SAHA tolerance in solid cancer cells.

Ding L1, Zhang Z1, Liang G1, Yao Z1, Wu H1, Wang B1, Zhang J1, Tariq M1, Ying M1, Yang B2.
Cancer letters.Cancer Lett.2015 Jan 28;356(2PB):828-836. doi: 10.1016/j.canlet.2014.10.034. Epub 2014 Nov 7.
Although SAHA is approved for the treatment of cutaneous T-cell lymphoma by the U.S. Food and Drug Administration, clinical trials using SAHA as a monotherapy or in combination with other chemotherapeutic agents in solid tumors have not met with success, and the mechanisms of tolerance remain unknow
PMID 25449774

Behzad H1, Tsai SH, Nassab P, Mousavizadeh R, McCormack RG, Scott A.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.J Orthop Res.2015 Jan;33(1):9-16. doi: 10.1002/jor.22742. Epub 2014 Oct 7.
Mast cells and fibroblasts are two key players involved in many fibrotic and degenerative disorders. In the present study we examined the nature of binding interactions between human mast cells and tendon fibroblasts (tenocytes). In the mast cell-fibroblast co-culture model, mast cells were shown to
PMID 25293783

Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells.

Sato R, Yamasaki M, Hirai K, Matsubara T, Nomura T, Sato F, Mimata H.
Oncology reports.Oncol Rep.2015 Jan;33(1):58-66. doi: 10.3892/or.2014.3586. Epub 2014 Nov 3.
Angiopoietin-like proteins (ANGPTLs), which comprise 7 members (ANGPTL1-ANGPTL7), structurally resemble angiopoietins. We investigated the roles of ANGPTLs in the acquisition of androgen independence and the malignant behavior of human prostate cancer cells. Expression of ANGPTL messenger RNA (mRNA
PMID 25370833

N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function : identification of the minimal N-glycosylation requirement for alpha5beta1