- インスリン様の、インシュリン様の
English Journal
- The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance.
- Castro AJ1, Frederico MJ1, Cazarolli LH2, Mendes CP1, Bretanha LC3, Schmidt ÉC4, Bouzon ZL4, de Medeiros Pinto VA5, da Fonte Ramos C5, Pizzolatti MG3, Silva FR6.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jan;1850(1):51-61. doi: 10.1016/j.bbagen.2014.10.001. Epub 2014 Oct 13.
- BACKGROUND: The effect of in vivo treatment with ursolic acid (UA) on glycemia in hyperglycemic rats and its mechanism of action on muscle were studied.METHODS: The UA effects on glycemia, glycogen, LDH, calcium and on insulin levels were evaluated after glucose tolerance curve. The β-cells were ev
- PMID 25312987
- Combined Potentiating Action of Phytochemical(s) from Cinnamomum tamala and Aloe vera for their Anti-diabetic and Insulinomimetic Effect Using In Vivo Rat and In Vitro NIH/3T3 Cell Culture System.
- Singh V1, Singh SP, Singh M, Gupta AK, Kumar A.
- Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2014 Dec 24. [Epub ahead of print]
- The present investigation was undertaken to analyze the ethanolic extracts of leaves of Cinnamomum tamala and Aloe vera for their anti-diabetic and insulinomimitic effect by determining the levels of blood sugar, glycosylated hemoglobin, and serum lipid profile (total cholesterol, triglycerides, hig
- PMID 25536877
- Novel sulfonyl(thio)urea derivatives act efficiently both as insulin secretagogues and as insulinomimetic compounds.
- Mascarello A1, Frederico MJ2, Castro AJ2, Mendes CP2, Dutra MF3, Woehl VM4, Yunes RA1, Mena Barreto Silva FR5, Nunes RJ6.
- European journal of medicinal chemistry.Eur J Med Chem.2014 Oct 30;86:491-501. doi: 10.1016/j.ejmech.2014.09.007. Epub 2014 Sep 6.
- Glibenclamide is widely used in the management of non-insulin dependent diabetes mellitus, but numerous risks limit its use in therapy. In the search for novel structures that are safer and more efficient than glibenclamide, we obtained new chemical analogs based on bioisosterism, through the treatm
- PMID 25203779
Japanese Journal
- 糖尿病克服を目指した新規Zn錯体の開発研究<br/>—配位元素置換による構造活性相関—
- 吉川 豊
- 薬学雑誌. 乙号 132(9), 1051-1055, 2012
- … Since the finding of insulinomimetic activity of Zn ion, several insulinomimetic Zn complexes have been reported. … Among the tropolonate-Zn complexes with various coordination environments, di(2-mercaptotropolonato)Zn with the Zn(S2O2) coordination environments was found to exhibit the highest in vitro insulinomimetic activity with respect to glucose uptake in isolated rat adipocytes treated with adrenaline. …
- NAID 130001888724
- 銅化合物による心血管障害及び糖尿病治療への実験的試み
- 桜井 弘
- 薬学雑誌. 乙号 132(3), 285-291, 2012
- … (1) improvement of cardiovascular dysfunction in animals by di-nuclear Cu-asprinate complex on the basis of the results on its reactive oxygen scavenging (ROS) effect, (2) blood glucose-lowering effect of mono-nuclear Cu-picolinate complex in streptozotocin (STZ)-induced type 1-like diabetic animals, based on the results on in vitro insulinomimetic activity, and (3) anti-diabetic effect of copper sulfate in animals with regard to the inhibition of α-glucosidase activity. …
- NAID 130001872022
- Oral Administration of Bis(aspirinato)zinc(II) Complex Ameliorates Hyperglycemia and Metabolic Syndrome-Like Disorders in Spontaneously Diabetic KK-Ay Mice: Structure-Activity Relationship on Zinc-Salicylate Complexes
- Yoshikawa Yutaka,Adachi Yusuke,Yasui Hiroyuki [他],Hattori Masakazu,Sakurai Hiromu
- Chemical and Pharmaceutical Bulletin 59(8), 972-977, 2011
- … The complexes with an electron-withdrawing group in the ligand exhibited higher in vitro insulinomimetic activity than those of Zn complexes with an electron-donating group in the ligand. …
- NAID 130000960928
Related Links
- The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J Biol Chem. 1990 Feb 15; 265(5):2896-902. [J Biol Chem. 1990] Combination of insulinomimetic agents H2O2 and vanadate ...
- New Insulinomimetic Zinc(II) Complexes of a-Amino Acids and Their Derivatives with Zn(N 2 O 2) Coordination Mode Yutaka YOSHIKAWA,a Eriko UEDA,a Yuka SUZUKI,b Naohisa YANAGIHARA,b Hiromu SAKURAI,c and Yoshitane ...
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