insulin-like growth factor binding protein 1

• インスリン様増殖因子結合タンパク質1、インスリン様成長因子結合タンパク質1

関

IGFBP-1

WordNet

1. want to have; "Id like a beer now!"
2. a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
3. a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
4. equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
5. resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
6. be fond of; "I like my nephews"
7. feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
8. find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. executed with proper legal authority; "a binding contract"
27. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
28. strip sewn over or along an edge for reinforcement or decoration
29. the capacity to attract and hold something

PrepTutorEJDIC

1. …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
2. (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
3. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
4. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
5. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
6. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/20 09:01:17」(JST)

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Insulin-like growth factor binding protein 1
PDB rendering based on 1zt3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZT3, 1ZT5, 2DSQ
Identifiers
Symbols	IGFBP1; AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
External IDs	OMIM: 146730 MGI: 96436 HomoloGene: 498 ChEMBL: 4178 GeneCards: IGFBP1 Gene
Gene Ontology Molecular function • insulin-like growth factor binding Cellular component • extracellular region • extracellular space Biological process • activation of signaling protein activity involved in unfolded protein response • signal transduction • insulin receptor signaling pathway • positive regulation of cell growth • endoplasmic reticulum unfolded protein response • tissue regeneration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3484	16006
Ensembl	ENSG00000146678	ENSMUSG00000020429
UniProt	P08833	P47876
RefSeq (mRNA)	NM_000596.2	NM_008341.4
RefSeq (protein)	NP_000587.1	NP_032367.3
Location (UCSC)	Chr 7: 45.93 – 45.93 Mb	Chr 11: 7.2 – 7.2 Mb
PubMed search	[1]	[2]

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

Further reading

• Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744.
• Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394.
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.
• Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.". Genomics 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120.
• Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.". Genomics 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735.
• Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1.". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175.
• Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783.
• Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104.
• Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513.
• Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522.
• Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665.
• Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129.
• Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445.
• Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945.
• Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653.
• Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931. //www.ncbi.nlm.nih.gov/pmc/articles/PMC338590/.
• Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269. //www.ncbi.nlm.nih.gov/pmc/articles/PMC47815/.
• Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.

UpToDate Contents

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English Journal

• Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents.

• Katz LE1, Gralewski KA1, Abrams P2, Brar PC3, Gallagher PR4, Lipman TH1, Brooks LJ5, Koren D6.
• Pediatric diabetes.Pediatr Diabetes.2016 Mar;17(2):77-86. doi: 10.1111/pedi.12242. Epub 2014 Dec 10.
• CONTEXT: Insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 have been linked to cardiovascular disease (CVD) risk and pathophysiology in adults, but there are limited data in youth.OBJECTIVE: The aim of the study was to examine the relationship between IGF and IGFBP-1 with traditio
• PMID 25491378

• Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin Sensitive Genes.

• Yalley A1, Schill D1, Hatta M1, Johnson N1, Cirillo LA2.
• The Journal of biological chemistry.J Biol Chem.2016 Feb 29. pii: jbc.M115.677583. [Epub ahead of print]
• FoxO1 binds to insulin response elements located in the promoters of insulin-like growth factor binding protein 1 (IGFBP1) and glucose-6-phosphatase (G6Pase), activating their expression. Insulin-mediated phosphorylation of FoxO1 promotes cytoplasmic translocation, inhibiting FoxO1-mediated transact
• PMID 26929406

• Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways.

• Gallagher EJ1, LeRoith D1, Franco R2, Antoniou IM1, Nayak A3, Livaudais-Toman J2, Bickell N2.
• Diabetes/metabolism research and reviews.Diabetes Metab Res Rev.2016 Feb 19. doi: 10.1002/dmrr.2795. [Epub ahead of print]
• BACKGROUND: Women with obesity and Type 2 diabetes (T2D) are at greater risk of dying from breast cancer than women without these conditions. Obesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia, and are more common in Black women. There is increasing disparity in b
• PMID 26896340

Japanese Journal

• Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine

• ACTA HISTOCHEMICA ET CYTOCHEMICA advpub(0), 2015
• NAID 130005114233

• Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes

• Biochemical and Biophysical Research Communications 448(1), 22-27, 2014-05-23
• NAID 120005457022

• CC Chemokine Ligand 18 and IGF-Binding Protein 6 as Potential Serum Biomarkers for Prostate Cancer

• The Tohoku Journal of Experimental Medicine 233(1), 25-31, 2014
• NAID 130004822410

Related Links

• Insulin-like growth factor binding protein-1: recent findings ...

1. Proc Soc Exp Biol Med. 1997 Dec;216(3):319-57. Insulin-like growth factor binding protein-1: recent findings and new directions. Lee PD, Giudice LC, Conover CA, Powell DR. Department of Pediatrics, Baylor College of Medicine ...

• Insulin-Like Growth Factor Binding Protein 1 | UCSF Profiles

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their ...

Related Pictures

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★リンクテーブル★

リンク元	「インスリン様増殖因子結合タンパク質1」「インスリン様成長因子結合タンパク質1」
関連記事	「binding」「like」「grow」「fact」「factor」

「インスリン様増殖因子結合タンパク質1」

　　[★]

英

insulin-like growth factor binding protein 1 IGFBP-1, insulin-like growth factor binding protein-1

同

インスリン様成長因子結合タンパク質1

関

インスリン様増殖因子結合タンパク質。腟分泌液中インスリン様成長因子結合蛋白1型

「インスリン様成長因子結合タンパク質1」

　　[★]

英

insulin-like growth factor binding protein 1、IGFBP-1

関

インスリン様増殖因子結合タンパク質1

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「like」

　　[★]

• v.

• 好む

• prep.

• 似ている、同様の

関

alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

　 　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter