insulin-like growth factor binding protein-1

同

IGFBP- 1

WordNet

1. want to have; "Id like a beer now!"
2. a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
3. a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
4. equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
5. resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
6. be fond of; "I like my nephews"
7. feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
8. find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. executed with proper legal authority; "a binding contract"
27. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
28. strip sewn over or along an edge for reinforcement or decoration
29. the capacity to attract and hold something

PrepTutorEJDIC

1. …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
2. (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
3. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
4. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
5. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
6. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 06:00:40」(JST)

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[Wiki en表示]

Insulin-like growth factor binding protein 1
PDB rendering based on 1zt3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZT3, 1ZT5, 2DSQ
Identifiers
Symbols	IGFBP1 ; AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
External IDs	OMIM: 146730 MGI: 96436 HomoloGene: 498 ChEMBL: 4178 GeneCards: IGFBP1 Gene
Gene ontology Molecular function • insulin-like growth factor binding Cellular component • extracellular region • extracellular space Biological process • activation of signaling protein activity involved in unfolded protein response • signal transduction • insulin receptor signaling pathway • positive regulation of cell growth • endoplasmic reticulum unfolded protein response • tissue regeneration • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3484	16006
Ensembl	ENSG00000146678	ENSMUSG00000020429
UniProt	P08833	P47876
RefSeq (mRNA)	NM_000596	NM_008341
RefSeq (protein)	NP_000587	NP_032367
Location (UCSC)	Chr 7: 45.93 – 45.93 Mb	Chr 11: 7.2 – 7.2 Mb
PubMed search	[1]	[2]

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

Further reading

• Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744. 
• Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53–67. doi:10.1159/000023315. PMID 10352394. 
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191. 
• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461. 
• Ehrenborg E, Larsson C, Stern I et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.". Genomics 12 (3): 497–502. doi:10.1016/0888-7543(92)90440-4. PMID 1373120.  CS1 maint: Explicit use of et al. (link)
• Ekstrand J, Ehrenborg E, Stern I et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.". Genomics 6 (3): 413–8. doi:10.1016/0888-7543(90)90470-F. PMID 1691735.  CS1 maint: Explicit use of et al. (link)
• Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1.". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175. 
• Brinkman A, Kortleve DJ, Schuller AG et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.". FEBS Lett. 291 (2): 264–8. doi:10.1016/0014-5793(91)81298-M. PMID 1718783.  CS1 maint: Explicit use of et al. (link)
• Brewer MT, Stetler GL, Squires CH et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. doi:10.1016/S0006-291X(88)80425-X. PMID 2454104.  CS1 maint: Explicit use of et al. (link)
• Julkunen M, Koistinen R, Aalto-Setälä K et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.". FEBS Lett. 236 (2): 295–302. doi:10.1016/0014-5793(88)80041-3. PMID 2457513.  CS1 maint: Explicit use of et al. (link)
• Lee YL, Hintz RL, James PM et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.". Mol. Endocrinol. 2 (5): 404–11. doi:10.1210/mend-2-5-404. PMID 2458522.  CS1 maint: Explicit use of et al. (link)
• Luthman H, Söderling-Barros J, Persson B et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.". Eur. J. Biochem. 180 (2): 259–65. doi:10.1111/j.1432-1033.1989.tb14641.x. PMID 2466665.  CS1 maint: Explicit use of et al. (link)
• Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.". Mol. Endocrinol. 3 (5): 846–51. doi:10.1210/mend-3-5-846. PMID 2474129. 
• Alitalo T, Kontula K, Koistinen R et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.". Hum. Genet. 83 (4): 335–8. doi:10.1007/BF00291377. PMID 2478445.  CS1 maint: Explicit use of et al. (link)
• Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.". Biochem. Biophys. Res. Commun. 157 (3): 898–907. doi:10.1016/S0006-291X(88)80959-8. PMID 2849945. 
• Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653. 
• Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.". Nucleic Acids Res. 16 (17): 8711. doi:10.1093/nar/16.17.8711. PMC 338590. PMID 3419931. 
• Jones JI, Gockerman A, Busby WH et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. doi:10.1073/pnas.90.22.10553. PMC 47815. PMID 7504269.  CS1 maint: Explicit use of et al. (link)
• Jones JI, Busby WH, Wright G et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.  CS1 maint: Explicit use of et al. (link)

UpToDate Contents

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• 1. Physiology of insulin-like growth factor 1
• 2. 妊娠37週未満の前期（陣痛開始前）破水 preterm premature prelabor rupture of membranes
• 3. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy
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• 5. HIV感染患者における下垂体および副腎の機能不全 pituitary and adrenal gland dysfunction in hiv infected patients

English Journal

• Krüppel-like factor 12 negatively regulates human endometrial stromal cell decidualization.

• Shen X, Hu Y, Jiang Y, Liu H, Zhu L, Jin X, Shan H, Zhen X, Sun L, Yan G, Sun H.SourceReproductive Medicine Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, People's Republic of China.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Feb 28. pii: S0006-291X(13)00351-3. doi: 10.1016/j.bbrc.2013.02.078. [Epub ahead of print]
• Members of the KLFs family of transcription factors play roles in maternal endometrium development during embryo implantation. However, the specific role of KLF12 in endometrium development has not yet been described. In this study, we showed that KLF12 expression in human endometrial stromal cells
• PMID 23458459

• Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations.

• Theuri G, Dallner G, Brismar K, Tekle M.SourceKenyatta University, School of Applied Human Sciences, Department of Exercise Recreation and Sports Science, Nairobi, Kenya.
• Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.Growth Horm IGF Res.2013 Feb 26. pii: S1096-6374(13)00004-X. doi: 10.1016/j.ghir.2013.01.003. [Epub ahead of print]
• OBJECTIVE: Overnight fasting blood plasma insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-1 (IGFBP-1), coenzyme Q10, (CoQ) vitamin E and plasma lipids were compared between a semi-nomadic Samburu population and relatively urbanized cohorts from Nairobi, Kenya.RESEARC
• PMID 23452916

• [Amniotic fluid embolism: An update.]

• Legrand M, Rossignol M, Muller F, Payen D.SourceDépartement d'anesthésie-réanimation-Smur, EA-3509, université Paris 7, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris, France. Electronic address: matthieu.m.legrand@gmail.com.
• Annales francaises d'anesthesie et de reanimation.Ann Fr Anesth Reanim.2013 Feb 16. pii: S0750-7658(13)00035-X. doi: 10.1016/j.annfar.2013.01.011. [Epub ahead of print]
• Amniotic fluid embolism (AFE) results from the passage of fœtal and amniotic fragments into the maternal circulation, occurring mostly within minutes before or after delivery. Although maternal and fœtal mortality of AFE remains high (about 40%), AFE should no longer be considered as having an ine
• PMID 23422343

Japanese Journal

• Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)

• Kawaguchi Kohei,Kaneko Nobuto,Fukuda Miki,Nakano Yusuke,Kimura Shizuo,Hara Akihiko,Shimizu Munetaka
• Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 165(2), 191-198, 2013-06
• … Two subtypes of insulin-like growth factor binding protein (IGFBP)-1 are present in salmon blood and they are both up-regulated under catabolic conditions such as stress. …
• NAID 120005228716

• P3-19-5 Late pretermにてInsulin-like Growth Factor Binding Protein-1 (IGFBP-1)陽性となった化学的前期破水の管理についての検討(Group 124 早産3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

• 石田 健太郎,深田 幸仁,中村 ゆりさ,東上 加波,関根 仁樹,船倉 翠,神部 友香理,川道 弥生,渡邉 征雄,武内 務,品川 寿弥,林 瑞成
• 日本産科婦人科學會雜誌 65(2), 911, 2013-02-01
• NAID 110009639473

• Insulin-like growth factor binding protein-related protein 1 is expressed in rheumatoid synovium and regulates synovial fibroblast proliferation

• SAKURAI Noriyuki,KUROIWA Takashi,KAYAKABE Ken,MATSUMOTO Takayuki,MAESHIMA Akito,HIROMURA Keiju,NOJIMA Yoshihisa
• Modern rheumatology 21(1), 63-72, 2011-02-01
• NAID 10029361344

Related Links

• Insulin-like growth factor binding protein-1: recent findings ...

1. Proc Soc Exp Biol Med. 1997 Dec;216(3):319-57. Insulin-like growth factor binding protein-1: recent findings and new directions. Lee PD(1), Giudice LC, Conover CA, Powell DR. Author information: (1 ...

• IGFBP1 insulin like growth factor binding protein 1 [ (human)]

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and ...

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★リンクテーブル★

リンク元	「インスリン様増殖因子結合タンパク質1」「IGFBP-1」
関連記事	「binding」「like」「grow」「fact」「factor」

「インスリン様増殖因子結合タンパク質1」

　　[★]

英

insulin-like growth factor binding protein 1 IGFBP-1, insulin-like growth factor binding protein-1

同

インスリン様成長因子結合タンパク質1

関

インスリン様増殖因子結合タンパク質。腟分泌液中インスリン様成長因子結合蛋白1型

「IGFBP-1」

　　[★] インスリン様増殖因子結合タンパク質1

同

insulin-like growth factor binding protein-1

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「like」

　　[★]

• v.

• 好む

• prep.

• 似ている、同様の

関

alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

　 　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter