同: IGFBP

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
become attached by or as if by the process of growth; "The tree trunks had grown together"
become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
cause to grow or develop; "He grows vegetables in his backyard"
increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
(pathology) an abnormal proliferation of tissue (as in a tumor)
a progression from simpler to more complex forms; "the growth of culture"
something grown or growing; "a growth of hair"
vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/03/30 10:58:48」(JST)

wiki en

The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1 (IGF-1).^[2]

Function

Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. This is important because proliferating IGF-1 + IGF-BP complex allow growth of the femur and the muscle.^{[citation needed]}

IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR.^[3]

The IGFBPs help to lengthen the half-life of circulating IGFs in all tissues, including the prostate.^[4] Individual IGFBPs may act to enhance or attenuate IGF signaling depending on their physiological context (i.e. cell type). Even with these similarities, some characteristics are different: chromosomal location, heparin binding domains, RGD recognition site, preference for binding IGF-I or IGF-II, and glycosylation and phophorylation differences.^[5] These structural differences can have a tremendous impact on how the IGFBPs interact with cellular basement membranes.

Family members

In humans, IGFBPs are transcribed from the following seven genes:

IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7

References

^ Kalus W, Zweckstetter M, Renner C, et al. (November 1998). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171003.
^ Hwa V, Oh Y, Rosenfeld RG (December 1999). "The insulin-like growth factor-binding protein (IGFBP) superfamily". Endocr. Rev. 20 (6): 761–87. doi:10.1210/er.20.6.761. PMID 10605625.
^ Clemmons DR, Busby WH, Arai T, Nam TJ, Clarke JB, Jones JI, Ankrapp DK (1995). "Role of insulin-like growth factor binding proteins in the control of IGF actions". Prog. Growth Factor Res. 6 (2-4): 357–66. doi:10.1016/0955-2235(95)00013-5. PMID 8817679.
^ Stewart CE, Bates PC, Calder TA, Woodall SM, Pell JM (September 1993). "Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins". Endocrinology 133 (3): 1462–5. doi:10.1210/en.133.3.1462. PMID 7689959.
^ Gregory CW, DeGeorges A, Sikes RA (2001). "The IGF axis in the development and progression of prostate cancer". Recent Research Developments in Cancer: 437–462. ISBN 81-7895-002-2.

External links

MeSH Insulin-like+growth+factor+binding+proteins

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1. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
2. 前期破水による早産 preterm premature rupture of membranes
3. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
4. 低身長に対する診断的アプローチ diagnostic approach to short stature
5. 慢性腎疾患を有する小児における成長障害の病因、評価および診断 pathogenesis evaluation and diagnosis of growth impairment in children with chronic kidney disease

English Journal

A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

Suh YA, Kim JH, Sung MA, Boo HJ, Yun HJ, Lee SH, Lee HJ, Min HY, Suh YG, Kim KW, Lee HY.SourceInstitute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Cancer letters.Cancer Lett.2013 May 10;332(1):102-9. doi: 10.1016/j.canlet.2013.01.022. Epub 2013 Jan 21.
In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF
PMID 23348700

Modification of a Small β-Barrel Protein, To Give Pseudo-Amyloid Structures, Inhibits Amyloid β-Peptide Aggregation.

Murakoshi Y, Takahashi T, Mihara H.SourceDepartment of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B40 Nagatsuta-cho, Midori-ku, Yokohama 226-8501 (Japan).
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2013 Apr 2;19(14):4525-31. doi: 10.1002/chem.201202762. Epub 2013 Feb 1.
Aggregation of amyloid β-peptide (Aβ) is closely related to the pathogenesis of Alzheimer's disease (AD). Although much effort has been devoted to the construction of molecules that inhibit the aggregation of Aβ1-42, high doses are needed for the inhibition of Aβ aggregation in many cases. Previ
PMID 23371795

Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.

Dietrich A, Mathia S, Kaminski H, Mutig K, Rosenberger C, Mrowka R, Bachmann S, Paliege A.SourceDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2013 Apr;207(4):721-31. doi: 10.1111/apha.12067. Epub 2013 Feb 18.
AIM: In the present study, we aimed to elucidate the effects of chronic vasopressin administration on renal medullary oxygen levels.METHODS: Adult Sprague Dawley or vasopressin-deficient Brattleboro rats were treated with the vasopressin V receptor agonist, desmopressin (5 ng/h; 3d), or its vehicle
PMID 23347696

Japanese Journal

Inhibitory effect of insulin-like growth factor-binding protein-7 (IGFBP7) on in vitro angiogenesis of vascular endothelial cells in the rat corpus luteum

TAMURA Kazuhiro,YOSHIE Mikihiro,HASHIMOTO Keisuke [他]
The journal of reproduction and development 60(6), 447-453, 2014-12
NAID 40020308695

Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes

Takahashi Kazuki,Kotani Tomoya,Katsu Yoshinao,Yamashita Masakane
Biochemical and Biophysical Research Communications 448(1), 22-27, 2014-05-23
… Besides cytoplasmic polyadenylation element-binding protein (CPEB) and cis-acting elements in the 3' untranslated region (UTR), Pumilio1 and a cis-acting element in the coding region of cyclin B1 mRNA are important for the subcellular localization and timing of translational activation of the mRNA. …
NAID 120005457022

Inhibitory Effect of Insulin-like Growth Factor-binding Protein-7 (IGFBP7) on In Vitro Angiogenesis of Vascular Endothelial Cells in the Rat Corpus Luteum

TAMURA Kazuhiro,YOSHIE Mikihiro,HASHIMOTO Keisuke,TACHIKAWA Eiichi
Journal of Reproduction and Development, 2014
… To explore the physiological significance of insulin-like growth factor-binding protein-7 (IGFBP7) in the developing CL, the effects of IGFBP7 on vascular endothelial growth factor (VEGFA)- and luteinizing hormone (LH)-induced in vitro tube formation were tested using isolated luteal microvascular endothelial cells (LECs). …
NAID 130004687238

Related Pictures

★リンクテーブル★

リンク元	「インスリン様成長因子結合タンパク質」「インスリン様増殖因子結合タンパク質」「インスリン様成長因子結合蛋白」「インスリン様成長因子結合蛋白質」「IGFBP」
拡張検索	「insulin-like growth factor binding protein 2」「insulin-like growth factor binding protein 3」「insulin-like growth factor binding protein 5」「insulin-like growth factor binding protein 6」
関連記事	「binding」「like」「grow」「fact」「factor」

「インスリン様成長因子結合タンパク質」

Insulin-like growth factor
binding protein
	Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5).
Identifiers
Symbol	IGFBP
Pfam	PF00219
InterPro	IPR000867
SMART	SM00121
PROSITE	PDOC00194
SCOP	1boe
SUPERFAMILY	1boe
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary