insulin-like growth factor

出典: meddic

インスリン様成長因子

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/18 11:26:51」(JST)

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英文文献

  • Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1.
  • Carrasco L, Cea P, Rocco P, Peña-Oyarzún D, Rivera-Mejias P, Sotomayor-Flores C, Quiroga C, Criollo A, Ibarra C, Chiong M, Lavandero S.Author information Advanced Center for Chronic Diseases, Universidad de Chile, Santiago, Chile; Centro Estudios Moleculares de la Celula, Facultad de Ciencias y Farmacéuticas, Universidad de Chile, Santiago, Chile.AbstractIn the heart, insulin-like growth factor-1 (IGF-1) is a peptide with pro-hypertrophic and anti-apoptotic actions. The pro-hypertrophic properties of IGF-1 have been attributed to the extracellular regulated kinase (ERK) pathway. Recently, we reported that IGF-1 also increases intracellular Ca(2+) levels through a pertussis toxin (PTX)-sensitive G protein. Here we investigate whether this Ca(2+) signal is involved in IGF-1-induced cardiomyocyte hypertrophy. Our results show that the IGF-1-induced increase in Ca(2+) level is abolished by the IGF-1 receptor tyrosine kinase inhibitor AG538, PTX and the peptide inhibitor of Gβγ signaling, βARKct. Increases in the activities of Ca(2+) -dependent enzymes calcineurin, calmodulin kinase II (CaMKII), and protein kinase Cα (PKCα) were observed at 5 min after IGF-1 exposure. AG538, PTX, βARKct, and the dominant negative PKCα prevented the IGF-1-dependent phosphorylation of ERK1/2. Participation of calcineurin and CaMKII in ERK phosphorylation was discounted. IGF-1-induced cardiomyocyte hypertrophy, determined by cell size and β-myosin heavy chain (β-MHC), was prevented by AG538, PTX, βARKct, dominant negative PKCα, and the MEK1/2 inhibitor PD98059. Inhibition of calcineurin with CAIN did not abolish IGF-1-induced cardiac hypertrophy. We conclude that IGF-1 induces hypertrophy in cultured cardiomyocytes by activation of the receptor tyrosine kinase activity/βγ-subunits of a PTX-sensitive G protein/Ca(2+) /PKCα/ERK pathway without the participation of calcineurin. J. Cell. Biochem. 115: 712-720, 2014. © 2013 Wiley Periodicals, Inc.
  • Journal of cellular biochemistry.J Cell Biochem.2014 Apr;115(4):712-20. doi: 10.1002/jcb.24712.
  • In the heart, insulin-like growth factor-1 (IGF-1) is a peptide with pro-hypertrophic and anti-apoptotic actions. The pro-hypertrophic properties of IGF-1 have been attributed to the extracellular regulated kinase (ERK) pathway. Recently, we reported that IGF-1 also increases intracellular Ca(2+) le
  • PMID 24243530
  • Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study.
  • Borinstein SC, Barkauskas DA, Bernstein M, Goorin A, Gorlick R, Krailo M, Schwartz CL, Wexler LH, Toretsky JA.Author information Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, TN, Tennessee.AbstractTo investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P < 0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P < 0.001). IGFBP-2 did not correlate with age (P = 0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P < 0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival. Pediatr Blood Cancer 2014;61:749-752. © 2013 Wiley Periodicals, Inc.
  • Pediatric blood & cancer.Pediatr Blood Cancer.2014 Apr;61(4):749-52. doi: 10.1002/pbc.24778. Epub 2013 Oct 31.
  • To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to ol
  • PMID 24178953
  • Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: Results from the ESMaestras cohort.
  • Rinaldi S, Biessy C, Hernandez M, Lesueur F, Dos-Santos-Silva I, Rice MS, Lajous M, Lopez-Ridaura R, Torres-Mejía G, Romieu I.Author information International Agency for Research on Cancer (IARC), Lyon, France.AbstractThe insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross-sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF-I, IGFBP-3, the IGF-I/IGFBP-3 ratio, five common SNPs in the IGF-1, IGFBP-3 and IGF-1R genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD = 3.7) years, and average body mass index (BMI) at recruitment was 28.5 kg/m(2) . Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm(2) . Mean IGF-I and IGFBP-3 concentrations were 15.33 (SD: 5.52) nmol/l and 114.96 (SD: 21.34) nmol/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF-I and IGF-I/IGFBP-3 concentrations had lower absolute dense (ptrend  = 0.03 and 0.09, respectively) and nondense tissue areas (ptrend  < 0.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1436-44. doi: 10.1002/ijc.28469. Epub 2013 Oct 5.
  • The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide po
  • PMID 24037648

和文文献

  • Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)
  • Kawaguchi Kohei,Kaneko Nobuto,Fukuda Miki,Nakano Yusuke,Kimura Shizuo,Hara Akihiko,Shimizu Munetaka
  • Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 165(2), 191-198, 2013-06-00
  • … Two subtypes of insulin-like growth factor binding protein (IGFBP)-1 are present in salmon blood and they are both up-regulated under catabolic conditions such as stress. … Circulating IGF-I levels significantly decreased after fasting for 5 weeks and were positively correlated with individual growth rates. … Muscle RNA/DNA ratio did not respond to fasting nor showed correlations with growth rates. …
  • NAID 120005228716
  • Cartilage-Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth
  • Tomita Nao,Hattori Takako,Itoh Shinsuke,Aoyama Eriko,Yao Mayumi,Yamashiro Takashi,Takigawa Masaharu
  • PLoS ONE 8(3), 2013-03-28
  • … Previously we showed that CCN family member 2/connective tissue growth factor (CCN2) promotes the proliferation, differentiation, and maturation of growth cartilage cells in vitro. … Our results also indicate the possible involvement of locally enhanced IGF-I or IGF-II in this extended bone growth. …
  • NAID 120005345532
  • Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.
  • Hayashi Yushi,Yamamoto Norio,Nakagawa Takayuki,Ito Juichi
  • Molecular and cellular neurosciences 56, 29-38, 2013-03-17
  • … These results indicate that IGF-1 is a growth factor that efficiently regulates different mechanisms through different downstream cascades, thereby protecting cochlear hair cells. …
  • NAID 120005244788

関連リンク

インスリン様成長因子(IGFs;Insulin-like growth factors)はインスリンと配列が高度に 類似したポリペプチドである。細胞培養ではインスリンと同様に有糸分裂誘発などの 反応を引き起こす。IGF-2は初期の発生に要求される第一の成長因子であると考え られるの ...

関連画像

Insulin Like Growth Factor 1 Wikipedia The Insulin-like growth factor 1 & 2 Exhibit Insulin Like Growth Factor 1 Wikipedia The Insulin-like growth factor 1 receptor File:2GF1 Insulin-Like Growth Factor Nmr File:1IGL Insulin-Like Growth Factor Ii 01


★リンクテーブル★
リンク元インスリン様成長因子」「IGF
拡張検索insulin-like growth factor receptor」「insulin-like growth factor binding protein 6」「insulin-like growth factor-I
関連記事like」「grow」「growth」「factor」「fact

インスリン様成長因子」

  [★]

insulin-like growth factor, insulin like growth factor IGF
インスリン様増殖因子インシュリン様成長因子インシュリン様増殖因子
ソマトメジン

種類




IGF」

  [★]


insulin-like growth factor receptor」

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IGF receptorIGFRsomatomedin receptor

insulin-like growth factor binding protein 6」

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IGFBP-6


insulin-like growth factor-I」

  [★] インスリン様成長因子-I

like」

  [★]

  • v.
  • prep.
alikeas well ascare forcorrespondcorrespondinglyequallyfavoridenticallylikewisepreferresemblesamesimilarsimilarlysuch

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「want to have; "I''d like a beer now!"」

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「a kind of person; "We''ll not see his like again"; "I can''t tolerate people of his ilk"」
ilk

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「a similar kind; "dogs, foxes, and the like", "we don''t want the likes of you around here"」
the like, the likes of

PrepTutorEJDIC   license prepejdic

「…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事」

PrepTutorEJDIC   license prepejdic

「(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように」

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「equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number"」
same

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「resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality"」
similar

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「be fond of; "I like my nephews"」

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「feel about or towards; consider, evaluate, or regard; "How did you like the President''s speech last night?"」

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「find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"」

grow」

  [★]

  • v.
(過去: grew-過去分詞: grown)
extendgrowthoutgrowoutgrowthstretch

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「cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here"」
raise, farm, produce

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「come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts"」
develop, produce, get, acquire

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「become attached by or as if by the process of growth; "The tree trunks had grown together"」

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「become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"」

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「cause to grow or develop; "He grows vegetables in his backyard"」

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「increase in size by natural process; "Corn doesn''t grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesn''t grow much anymore"」

PrepTutorEJDIC   license prepejdic

「『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)」

growth」

  [★]

  • n.
  • 成長


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「(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children"」
growing, maturation, development, ontogeny, ontogenesis

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「(pathology) an abnormal proliferation of tissue (as in a tumor)」

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「a progression from simpler to more complex forms; "the growth of culture"」

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「something grown or growing; "a growth of hair"」

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「vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"」

PrepTutorEJDIC   license prepejdic

「〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)」

factor」

  [★]

  • n.
elementelementaryfactorialparameter

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「be a contributing factor; "make things factor into a company''s profitability"」

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「any of the numbers (or symbols) that form a product when multiplied together」

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「an independent variable in statistics」

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「anything that contributes causally to a result; "a number of factors determined the outcome"」

PrepTutorEJDIC   license prepejdic

「(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize」

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「consider as relevant when making a decision; "You must factor in the recent developments"」
factor in, factor out

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「resolve into factors; "a quantum computer can factor the number 15"」
factor in, factor out

fact」

  [★]

  • n.
actualactuallyin factin practiceindeedpractically

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「an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"」

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「a concept whose truth can be proved; "scientific hypotheses are not facts"」

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「a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"」

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「a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"」

PrepTutorEJDIC   license prepejdic

「〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行」



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