English Journal

Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts.

Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff A, Santhoshkumar P, Nagaraj RH.SourceCase Western Reserve University, United States;
The Journal of biological chemistry.J Biol Chem.2013 Mar 18. [Epub ahead of print]
α-Crystallin is a member of the small heat-shock protein (sHSP) family and consists of two subunits, αA- and αB-. Both αA- and αB-crystallin act as chaperones and anti-apoptotic proteins. Previous studies have identified the peptide 70KFVIFLDVKHFSPEDLTVK88 in αA-crystallin and the peptide 73DR
PMID 23508955

Rutin ameliorates free radical mediated cataract by enhancing the chaperone activity of α-crystallin.

Sasikala V, Rooban BN, Sahasranamam V, Abraham A.SourceDepartment of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695581, Kerala, India.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.Graefes Arch Clin Exp Ophthalmol.2013 Feb 15. [Epub ahead of print]
BACKGROUND: Cataract, the leading cause of blindness, is associated with oxidative damage and protein modification in the lens. The present study was carried out to assess the efficacy of rutin on rat-lens crystallins in selenite-induced in-vivo cataract models.METHODS: Eight-day-old Sprague-Dawley
PMID 23412395

Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.

Ohnishi K, Nakahata E, Irie K, Murakami A.SourceDivision of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Jan 11;430(2):616-22. doi: 10.1016/j.bbrc.2012.11.104. Epub 2012 Dec 5.
Zerumbone, a sesquiterpene present in Zingiber zerumbet Smith, has been implicated as a promising chemopreventive agent. Interestingly, a number of studies have revealed that its potent bioactivities are dependent on the electrophilic moiety of its α,β-unsaturated carbonyl group, while our recent
PMID 23219816