inoculation metastasis

出典: meddic

英文文献

  • ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.
  • Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE.Author information Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.AbstractThe transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8 promoted an aggressive phenotype of TNBC cells in culture. In a mouse orthotopic model, tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. Mechanistically, ADAM8 stimulated both angiogenesis through release of VEGF-A and transendothelial cell migration via β1-integrin activation. In vivo, treatment with an anti-ADAM8 antibody from the time of cell inoculation reduced primary tumor burden and metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model. As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination.
  • EMBO molecular medicine.EMBO Mol Med.2014 Jan 9. [Epub ahead of print]
  • The transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breas
  • PMID 24375628
  • Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
  • Sanz G1, Leray I2, Dewaele A1, Sobilo J3, Lerondel S3, Bouet S4, Grébert D1, Monnerie R1, Pajot-Augy E1, Mir LM2.Author information 1INRA, UR1197 Neurobiologie de l'Olfaction et Modélisation en Imagerie, Jouy-en-Josas, France ; IFR 144 NeuroSud Paris, Gif-sur-Yvette, France.2CNRS, UMR8203 Vectorologie et thérapeutiques anti-cancéreuses, Institut Gustave-Roussy, Villejuif, France ; Univ. Paris-Sud, UMR8203, Orsay, France.3CNRS-TAAM, UPS44, Centre d'Imagerie du Petit Animal, Orléans, France.4INRA, UMR 1313, Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France ; CEA, DSV, IRCM, SREIT, Laboratoire de Radiobiologie et Etude du Génome, Jouy-en-Josas, France ; AgroParisTech, UMR 1313, Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.AbstractOlfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells by RT-PCR, showing that single cells can co-express several ORs. Some of the receptors identified were already reported in other tumors, but they are orphan (without known ligand), as it is the case for most of the hundreds of human ORs. Thus, genes coding for human ORs with known ligands were transfected into these cells, expressing functional heterologous ORs. The in vitro stimulation of these cells by the corresponding OR odorant agonists promoted cell invasion of collagen gels. Using LNCaP prostate cancer cells, the stimulation of the PSGR (Prostate Specific G protein-coupled Receptor), an endogenously overexpressed OR, by β-ionone, its odorant agonist, resulted in the same phenotypic change. We also showed the involvement of a PI3 kinase γ dependent signaling pathway in this promotion of tumor cell invasiveness triggered by OR stimulation. Finally, after subcutaneous inoculation of LNCaP cells into NSG immunodeficient mice, the in vivo stimulation of these cells by the PSGR agonist β-ionone significantly enhanced metastasis emergence and spreading.
  • PloS one.PLoS One.2014 Jan 8;9(1):e85110. doi: 10.1371/journal.pone.0085110.
  • Olfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells by RT-PCR, showing that sin
  • PMID 24416348

和文文献

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★リンクテーブル★
関連記事inoculation」「metastasis

inoculation」

  [★]

  • n.
disseminatedisseminationinoculainoculateinoculumseedseedingsowing

WordNet   license wordnet

「taking a vaccine as a precaution against contracting a disease」
vaccination

PrepTutorEJDIC   license prepejdic

「予防接種すること:〈C〉予防注射」

metastasis」

  [★]

  • n.
meta, ガン転移

WordNet   license wordnet

「the spreading of a disease (especially cancer) to another part of the body」

PrepTutorEJDIC   license prepejdic

「(癌(がん)などの)転移」




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