WordNet
- taking a vaccine as a precaution against contracting a disease (同)vaccination
- the spreading of a disease (especially cancer) to another part of the body
PrepTutorEJDIC
- 予防接種すること:〈C〉予防注射
- (癌(がん)などの)転移
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- 1. 肺癌の腫瘍、結節、転移による（TNM）病期分類システムtumor node metastasis tnm staging system for lung cancer [show details]
- 2. 乳癌の腫瘍、リンパ節、転移による（TNM）病期分類tumor node metastasis tnm staging classification for breast cancer [show details]
- 3. 骨転移のある成人患者の疫学、臨床症状、診断epidemiology clinical presentation and diagnosis of bone metastasis in adults [show details]
- 4. 固形癌が骨転移した成人患者への治療アプローチの概要overview of therapeutic approaches for adult patients with bone metastasis from solid tumors [show details]
- 5. 大腸癌肝転移に対する肝切除術hepatic resection for colorectal cancer liver metastasis [show details]
English Journal
- ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.
- Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg A, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE.Author information Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.AbstractThe transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8 promoted an aggressive phenotype of TNBC cells in culture. In a mouse orthotopic model, tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. Mechanistically, ADAM8 stimulated both angiogenesis through release of VEGF-A and transendothelial cell migration via β1-integrin activation. In vivo, treatment with an anti-ADAM8 antibody from the time of cell inoculation reduced primary tumor burden and metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model. As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination.
- EMBO molecular medicine.EMBO Mol Med.2014 Jan 9. [Epub ahead of print]
- The transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breas
- PMID 24375628
- Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
- Sanz G1, Leray I2, Dewaele A1, Sobilo J3, Lerondel S3, Bouet S4, Grébert D1, Monnerie R1, Pajot-Augy E1, Mir LM2.Author information 1INRA, UR1197 Neurobiologie de l'Olfaction et Modélisation en Imagerie, Jouy-en-Josas, France ; IFR 144 NeuroSud Paris, Gif-sur-Yvette, France.2CNRS, UMR8203 Vectorologie et thérapeutiques anti-cancéreuses, Institut Gustave-Roussy, Villejuif, France ; Univ. Paris-Sud, UMR8203, Orsay, France.3CNRS-TAAM, UPS44, Centre d'Imagerie du Petit Animal, Orléans, France.4INRA, UMR 1313, Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France ; CEA, DSV, IRCM, SREIT, Laboratoire de Radiobiologie et Etude du Génome, Jouy-en-Josas, France ; AgroParisTech, UMR 1313, Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.AbstractOlfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells by RT-PCR, showing that single cells can co-express several ORs. Some of the receptors identified were already reported in other tumors, but they are orphan (without known ligand), as it is the case for most of the hundreds of human ORs. Thus, genes coding for human ORs with known ligands were transfected into these cells, expressing functional heterologous ORs. The in vitro stimulation of these cells by the corresponding OR odorant agonists promoted cell invasion of collagen gels. Using LNCaP prostate cancer cells, the stimulation of the PSGR (Prostate Specific G protein-coupled Receptor), an endogenously overexpressed OR, by β-ionone, its odorant agonist, resulted in the same phenotypic change. We also showed the involvement of a PI3 kinase γ dependent signaling pathway in this promotion of tumor cell invasiveness triggered by OR stimulation. Finally, after subcutaneous inoculation of LNCaP cells into NSG immunodeficient mice, the in vivo stimulation of these cells by the PSGR agonist β-ionone significantly enhanced metastasis emergence and spreading.
- PloS one.PLoS One.2014 Jan 8;9(1):e85110. doi: 10.1371/journal.pone.0085110.
- Olfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect odorants, but also in other tissues with additional functions. Some ORs are even overexpressed in tumor cells. In this study, we identified ORs expressed in enterochromaffin tumor cells by RT-PCR, showing that sin
- PMID 24416348
Japanese Journal
- Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia
- Retrovirology 12, 99, 2015-11-24
- NAID 120005690998
- Carbonyl reductase 1を標的分子とした子宮頸癌の新規分子標的治療の開発に向けて(シンポジウム2(腫瘍):子宮頸部腫瘍の病態に関する新知見-診断・治療法の開発に向けて-,第67回日本産科婦人科学会学術講演会講演要旨)
- 日本産科婦人科學會雜誌 67(11), 2554-2561, 2015-11-01
- NAID 110010000757
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