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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/20 16:44:23」(JST)

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  • Use of detergent-based buffers allows detection of precursor inhibin forms in an immunoassay format.
  • Walton KL, Chan KL, Pruysers E, Kelly EK, Harris G, Harrison CA, Robertson DM.SourcePrince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia.
  • Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Dec 5;381(1-2):106-14. doi: 10.1016/j.mce.2013.07.022. Epub 2013 Jul 30.
  • Inhibin ELISAs are used in monitoring aspects of reproductive function, however these assays are based on the measurements of the mature 30kDa inhibin forms and not precursor forms. In conventional ELISA formats, the 105kDa unprocessed 'Pro-inhibin' forms are immunologically inactive, but the immuno
  • PMID 23911899
  • Management of hypogonadism in adolescent girls and adult women with Prader-Willi syndrome.
  • Eldar-Geva T, Hirsch HJ, Pollak Y, Benarroch F, Gross-Tsur V.SourceThe Israel Multidisciplinary Prader-Willi Syndrome Clinic, Jerusalem, Israel; Reproductive Endocrinology and Genetics Unit, Department of Obstetrics and Gynecology, Shaare-Zedek Medical Center, Jerusalem, Israel; Hebrew University School of Medicine, Jerusalem, Israel.
  • American journal of medical genetics. Part A.Am J Med Genet A.2013 Dec;161(12):3030-4. doi: 10.1002/ajmg.a.36152. Epub 2013 Aug 16.
  • Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by an insatiable appetite, dysmorphic features, cognitive and behavioral difficulties, and hypogonadism. The heterogeneous reproductive hormone profiles indicate that some PWS women may have symptoms of hypoestrogenism, while
  • PMID 24038925
  • Uterine tumors resembling ovarian sex cord tumors.
  • Pradhan D, Mohanty SK.SourceFrom the Department of Pathology and Laboratory Medicine, Pushpanjali Crosslay Hospital, Ghaziabad, Delhi NCR, India.
  • Archives of pathology & laboratory medicine.Arch Pathol Lab Med.2013 Dec;137(12):1832-6. doi: 10.5858/arpa.2012-0634-RS.
  • Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare neoplasms of unknown etiology. Only 67 cases have been reported in the literature, to our knowledge, so far. The neoplasm usually occurs in middle-aged women. Most patients present with abnormal uterine bleeding and/or abdominal pa
  • PMID 24283865


  • 3) 中高年女性の健康管理プログラム策定における基礎的・臨床的検討(シンポジウム1:女性ヘルスケア「中高年に対する女性医学の展開」,第64回日本産科婦人科学会・学術講演会)
  • 樋口 毅
  • 日本産科婦人科學會雜誌 64(10), 2191-2202, 2012-10-01
  • … Pursuing the inhibin B, follicular stimulating hormone (FSH) and 17beta-estradiol (E2) were also measured besides AMH from same cases for several years in the 256 healthy women participated repeatedly in Iwaki Project and the relationships of each data with onset of the menopause or irregular cycle of menstruation were compared respectively. …
  • NAID 110009518075
  • Effects of Sulfamethazine on Induction of Precocious Puberty in Japanese Quails (Coturnix japonica) Assessed through Monitoring the Hormonal Changes and Gonadal Development
  • SEDQYAR Manila,KANDIEL Mohamed M.M.,WENG Qiang [他],NAGAOKA Kentarou,WATANABE Gen,TAYA Kazuyoshi
  • The Journal of reproduction and development 58(5), 563-568, 2012-10-01
  • … Hormonal analysis revealed a substantial increase in the pituitary and circulating LH (at the 5th and 6th weeks), testicular and circulating testosterone (at the 6th week) and plasma ir-inhibin (at 5th week) levels following feeding of the diet containing SMZ. … The SMZ supplemented group showed a significant elevation in pituitary LH content (from the 4th week), plasma LH (at the 5th and 6th weeks), ir-inhibin (at the 3rd and 6th week) and progesterone (at the 2nd, 5th and 6th weeks) as compared with control chicks. …
  • NAID 10031123301
  • Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary
  • SHENG Xia,WENG Jiaju,ZHANG Haolin [他],LI Xiaonan,ZHANG Mengyuan,XU Meiyu,WENG Qiang,WATANABE Gen,TAYA Kazuyoshi
  • The Journal of reproduction and development 58(5), 531-536, 2012-10-01
  • … The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. … Immunohistochemical staining and Western blotting have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (α, βA and βB). … Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. …
  • NAID 10031123296




拡張検索inhibin-beta subunit」「inhibin/activin system



anterior pituitary hormone


GOO. chapter 55

名称 構造 分泌細胞 下垂体前葉細胞
染色性 サブユニット 残基数
成長ホルモン GH ペプチド somatotroph 40-50% 好酸性   1 191 22  
プロラクチン PRL mammotroph 10-25% 好酸性   1 199 23  
副腎皮質刺激ホルモン ACTH corticotroph 0.1 好塩基性 嫌色素性 1 39 4.5 POMC由来
甲状腺刺激ホルモン TSH 糖タンパク thyrotroph 0.05 好塩基性   2 α: 92, β:118 28 αサブユニットは共通
卵胞刺激ホルモン FSH gonadotroph 10-15% 好塩基性   2 α: 92, β:111 32.6
黄体形成ホルモン LH 好塩基性   2 α: 92, β:121 29.4


Table 333-1 Anterior Pituitary Hormone Expression and Regulation
Cell corticotrope somatotrope lactotrope thyrotrope gonadotrope
Tissue-specific transcription factor T-Pit Prop-1, Pit-1 Prop-1, Pit-1 Prop-1, Pit-1, TEF SF-1, DAX-1
Fetal appearance 6 weeks 8 weeks 12 weeks 12 weeks 12 weeks
Chromosomal locus 2p 17q 6 -6q; -1p -11p; -19q
Protein ポリペプチド 糖タンパク
Amino acids 266 (ACTH 1–39) 191 199 211 210 204
Stimulators CRH, AVP, gp-130 cytokines GHRH, ghrelin, bromocriptine(1) estrogen, TRH, VIP TRH GnRH, activins, estrogen
Inhibitors glucocorticoids somatostatin, IGF-I dopamine T3, T4, dopamine, somatostatin, glucocorticoids sex steroids, inhibin
Target gland adrenal liver, other tissues breast, other tissues thyroid ovary, testis
Trophic effect steroid production IGF-I production, growth induction, insulin antagonism milk production T4 synthesis and secretion sex steroid production, follicle growth, germ cell maturation







  • ペプチド?


  • 主に性腺
  • 男性:精巣:セルトリ細胞
  • 女性:卵巣:顆粒細胞。卵胞の顆粒膜細胞・莢膜細胞(NGY.26)


  • 下垂体前葉


inhibin-beta subunit」



inhibin/activin system」

  [★] インヒビン/アクチビン系

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