関: infundibulum

WordNet

any of various funnel-shaped parts of the body (but especially the hypophyseal stalk)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 結核における腎疾患 renal disease in tuberculosis
2. Fox-Fordyce disease (apocrine miliaria)
3. 苔癬型薬疹（薬剤誘発性扁平苔癬) lichenoid drug eruption drug induced lichen planus
4. Granular parakeratosis
5. ロボミコーシス lobomycosis

English Journal

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice.

Schäfer M1, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, Bloch W, Beer HD, Werner S.Author information 1Department of Biology, Institute of Molecular Health Sciences, ETH Zurich Zurich, Switzerland.AbstractThe transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mice due to upregulation of the growth factor epigen, which we identified as a novel Nrf2 target. This was accompanied by thickening and hyperkeratosis of hair follicle infundibula. These abnormalities caused dilatation of infundibula, hair loss, and cyst development upon aging. Upregulation of epigen, secretory leukocyte peptidase inhibitor (Slpi), and small proline-rich protein 2d (Sprr2d) in hair follicles was identified as the likely cause of infundibular acanthosis, hyperkeratosis, and cyst formation. These alterations were highly reminiscent to the phenotype of chloracne/"metabolizing acquired dioxin-induced skin hamartomas" (MADISH) patients. Indeed, SLPI, SPRR2, and epigen were strongly expressed in cysts of MADISH patients and upregulated by dioxin in human keratinocytes in an NRF2-dependent manner. These results identify novel Nrf2 activities in the pilosebaceous unit and point to a role of NRF2 in MADISH pathogenesis.
EMBO molecular medicine.EMBO Mol Med.2014 Apr 1;6(4):442-57. doi: 10.1002/emmm.201303281. Epub 2014 Feb 6.
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mi
PMID 24503019

In-office, multisinus balloon dilation: 1-Year outcomes from a prospective, multicenter, open label trial.

Gould J1, Alexander I, Tomkin E, Brodner D.Author information 1St. Louis Sinus Center, St. Louis, Missouri, USA.AbstractBACKGROUND: The objective of this prospective, multicenter study was to assess 1-year changes in sinonasal symptoms and health care use after office-based multisinus balloon dilation.
American journal of rhinology & allergy.Am J Rhinol Allergy.2014 Mar;28(2):156-63. doi: 10.2500/ajra.2014.28.4043. Epub 2014 Feb 14.
BACKGROUND: The objective of this prospective, multicenter study was to assess 1-year changes in sinonasal symptoms and health care use after office-based multisinus balloon dilation.METHODS: Adults diagnosed with chronic or recurrent acute rhinosinusitis per the 2007 adult sinusitis guidelines were
PMID 24598043

Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury.

Lian CG1, Bueno EM2, Granter SR1, Laga AC1, Saavedra AP3, Lin WM3, Susa JS4, Zhan Q1, Chandraker AK5, Tullius SG6, Pomahac B2, Murphy GF1.Author information 1Division of Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.2Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.3Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.4Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.5Division of Renal Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.6Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.AbstractThis series of 113 sequential biopsies of full facial transplants provides findings of potential translational significance as well as biological insights that could prompt reexamination of conventional paradigms of effector pathways in skin allograft rejection. Serial biopsies before, during, and after rejection episodes were evaluated for clinicopathological assessment that in selected cases included specific biomarkers for donor-versus-recipient T cells. Histologic evidence of rejection included lymphocyte-associated injury to epidermal rete ridges, follicular infundibula, and dermal microvessels. Surprisingly, during active rejection, immune cells spatially associated with target cell injury consisted abundantly or predominantly of lymphocytes of donor origin with an immunophenotype typical of the resident memory T-cell subset. Current dogma assumes that skin allograft rejection is mediated by recipient T cells that attack epidermal targets, and the association of donor T cells with sites of target cell injury raises questions regarding the potential complexity of immune cell interactions in the rejection process. A more histopathologically refined and immune-based biomarker approach to assessment of rejection of facial transplants is now indicated.Modern Pathology advance online publication, 17 January 2014; doi:10.1038/modpathol.2013.249.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.Mod Pathol.2014 Jan 17. doi: 10.1038/modpathol.2013.249. [Epub ahead of print]
This series of 113 sequential biopsies of full facial transplants provides findings of potential translational significance as well as biological insights that could prompt reexamination of conventional paradigms of effector pathways in skin allograft rejection. Serial biopsies before, during, and a
PMID 24434898

Japanese Journal

冬季の九州西岸における Dinophysis 属渦鞭毛藻の分布

圦本達也,前野幸男,木元克則
水産増殖 54(4), 455-464, 2006-12-20
… infundibulaの5種が観察された。 … infundibulaが11.3～16.5℃・31.1～34.4PSUであった。 …
NAID 10018710496

Automatic characterization and segmentation of human skin using three-dimensional optical coherence tomography

Hori Yasuaki,Yasuno Yoshiaki,Sakai Shingo,Matsumoto Masayuki,Sugawara Tomoko,Madjarova Violeta Dimitrova,Yamanari Masahiro,Makita Shuichi,Yasui Takeshi,Araki Tsutomu,Itoh Masahide,Yatagai Toyohiko,安野嘉晃,伊藤雅英
Optics Express 14(5), 1862-1877, 2006-03
… Subsequently, an en face shadowgram is produced by an algorithm to visualize the infundibula in the skin with high contrast. … The population and occupation ratio of the infundibula are provided by a histogram-based thresholding algorithm and a distance mapping algorithm. … En face OCT slices at constant depths from the sample surface are extracted, and the histogram-based thresholding algorithm is again applied to these slices, yielding a three-dimensional segmented volume of the infundibula. …
NAID 120002836934

ハト肺血管系の微細構造の走査電顕的観察(解剖学)

那須哲夫
The journal of veterinary medical science 67(10), 1071-1074, 2005-10-25
ハトの肺の気道と血管系の鋳型標本を作製, その走行を走査型電子顕微鏡で観察した.一次気管支は多くの二次気管支を分岐し, この二次気管支は傍気管支を介してお互いに吻合していた.傍気管支側壁の肺房から無数の漏斗が突出し, 先端部は含気毛細管を分岐していた.肺動脈は肺内で3枝に分かれ, 各々は傍気管支間を走行する小動脈を形成していた.気道と血管系の重複鋳型の観察では, 含気毛細管と毛細血管が緻密な三次元 …
NAID 110003983132