UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 先天性爪肥厚症pachyonychia congenita [show details]
…chromosome 12q13.13 . During keratin filament assembly, keratins form obligate heterodimers consisting of a type I and a type II keratin. The 10-nm keratin filaments form cytoskeletal networks spanning …
2. 眼咽頭型、遠位型，および先天性筋ジストロフィーoculopharyngeal distal and congenital muscular dystrophies [show details]
…binding protein nuclear 1 gene (PABPN1, previously called PABP2) . The normal PABPN1 gene contains 10 repeats . In OPMD, autosomal dominant inheritance occurs with expanded alleles that range from 12 to … of myopathies that include the following types : Nonaka myopathy; Miyoshi muscular dystrophy 1; Miyoshi muscular dystrophy…
3. 下肢末梢動脈疾患の症状を治療するための試験的治療investigational therapies for treating symptoms of lower extremity peripheral artery disease [show details]
… were treated over a period of 10 weeks with either placebo (n = 18) or sodium nitrite twice daily,… class are no longer under investigation despite positive results for other drugs in this class such as NM-702 and K-134 . Prostaglandin, prostacyclin, and their analogs improve blood flow through direct…
4. 鎌状ヘモグロビン多量体：構造と機能特性sickle hemoglobin polymer structure and functional properties [show details]
… cross-section of about 23 nm by 18 nm . Since hemoglobin tetramers are globular molecules with a diameter of about 5.5 nm,… structure is a double-stranded filament. Each strand is a string of deoxy Hb S beads aligned in head to tail (or axial) array. Seven filaments combine into a fiber organized… twisted rope-like structure is composed of an inner core of four strands surrounded by a sheath of 10 . The double strands are slightly twisted in the fiber. Stretching of the outer strands in the fiber …
5. UVB療法（広帯域および狭帯域）uvb therapy broadband and narrowband [show details]
… to 320 nm) and the rest is primarily in the UVA range (320 to 400 nm) . Devices for narrowband UVB therapy use the TL-01 fluorescent lamps that emit UVB in the range of 311 to 313 nm .… and IL-12 and increased secretion of IL-4 and IL-10 ; Functional impairment of epidermal Langerhans cells…