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Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.

Qi Q, Menzaghi C, Smith S, Liang L, de Rekeneire N, Garcia ME, Lohman KK, Miljkovic I, Strotmeyer ES, Cummings SR, Kanaya AM, Tylavsky FA, Satterfield S, Ding J, Rimm EB, Trischitta V, Hu FB, Liu Y, Qi L.SourceDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Human molecular genetics.Hum Mol Genet.2012 Nov 1;21(21):4774-80. doi: 10.1093/hmg/dds300. Epub 2012 Jul 26.
Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease. We conducted a genome-wide association (GWA) study on circulating resistin levels in individuals of European ancestry drawn from the two
PMID 22843503

Mechanism of the chaperone-like and antichaperone activities of amyloid fibrils of peptides from αA-crystallin.

Fukuhara S, Nishigaki T, Miyata K, Tsuchiya N, Waku T, Tanaka N.SourceDepartment of Biomolecular Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo, Japan.
Biochemistry.Biochemistry.2012 Jul 10;51(27):5394-401. Epub 2012 Jun 25.
The amyloid fibril of a fragment of the substrate binding site of αA-crystallin (αAC(71-88)) exhibited chaperone-like activity by suppressing the aggregation of alcohol dehydrogenase (ADH) and luciferase. By contrast, the amyloid fibril of the cytotoxic fragment of amyloid β protein (Aβ(25-35))
PMID 22694216

Crystallin distribution patterns in Litoria infrafrenata and Phyllomedusa sauvagei lenses.

Keenan J, Manning G, Elia G, Dunn MJ, Orr DF, Pierscionek BK.SourceSchool of Biomedical Sciences, University of Ulster, Coleraine, UK.
Proteomics.Proteomics.2012 Jun;12(11):1830-43. doi: 10.1002/pmic.201100393.
The eye lens remains transparent because of soluble lens proteins known as crystallins. For years γ-crystallins have been known as the main lens proteins in lower vertebrates such as fish and amphibians. The unique growth features of the lens render it an ideal structure to study ageing; few studie
PMID 22623336

Novel Use of Bovine Zeta-Crystallin as a Conformational DNA Probe to Characterize a Phase Transition Zone and Terminally Differentiating Fiber Cells in the Adult Canine Ocular Lens

GAGNA Claude E.,KUO Hon-Reen,AGOSTINO Nick,RIZZO Douglas,ISQUITH Irwin R.,MATHEW Joslyn,MOHAMMED Jubina,HOO Sheldon,CLARK LAMBERT W.
Archives of histology and cytology 64(4), 379-391, 2001-10-01
… The binding to DNA of zeta(ζ)-crystallin (Z-DNA-binding protein) and anti-double-stranded (ds-)-B-DNA antibody probes was found to decline gradually throughout denucleating fibers, with a precipitous decrease occurring at about 100 μm (PTZ). … With the use of ζ-crystallin, anti-ds-B-DNA antibody, and anti-single stranded (ss-) DNA antibody probes, it was possible to reveal a loss of reactivity of fiber cell ds-DNA. …
NAID 10013026378

藤井豊,木元久,石川恵子 [他],渡部紀久子,武藤明,中井昇
福井医科大学研究雑誌 1(2), 233-240, 2000-06-30
… ρ-Crystallin, a taxon-specific crystallin, expressed in the lenses of American Bullfrog (Rana catesbeiana) and Black-spotted Pond Frog (Rana nigromaculata) occupies about 8% of the wet-weight of their tissues. … The crystallin belongs to the superfamily of aldo-keto reductases, but shows no enzymatic activity. … The present study demonstrates that ζ-crystallin, instead of ρ-crystallin, is expressed in the lens of tree frog (Hyla japonica). …
NAID 110004839225