WordNet
- relating to or characterized by or aiming toward unity; "the unitary principles of nationalism"; "a unitary movement in politics"
- characterized by or constituting a form of government in which power is held by one central authority; "a unitary as opposed to a federal form of government"
- of or pertaining to or involving the use of units; "a unitary method was applied"; "established a unitary distance on which to base subsequent calculations"
- a materials capacity to conduct electricity; measured as the reciprocal of electrical resistance
PrepTutorEJDIC
- (熱・電気などの)伝導度
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- 1. 血液透析における水質の維持 maintaining water quality for hemodialysis
- 2. 神経伝導検査：応答遅延 nerve conduction studies late responses
- 3. 自動血液分析装置 automated hematology instrumentation
- 4. 熱傷の分類 classification of burns
- 5. 食道内多チャンネルインピーダンス検査 esophageal multichannel intraluminal impedance testing
English Journal
- Intrinsic properties and regulation of Pannexin 1 channel.
- Chiu YH1, Ravichandran KS2, Bayliss DA1.Author information 1Department of Pharmacology; University of Virginia; Charlottesville, VA USA.2Beirne B. Carter Center for Immunology Research; University of Virginia; Charlottesville, VA USA; Center for Cell Clearance; University of Virginia; Charlottesville, VA USA; Department of Microbiology; Immunology and Cancer Research; University of Virginia; Charlottesville, VA USA.AbstractPannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via proteolytic cleavage of the Panx1 C-terminus. Panx1 channels are widely expressed in various cell types, and it is now thought that targeting these channels therapeutically may be beneficial in a number of pathophysiological contexts, such as asthma, atherosclerosis, hypertension, and ischemic-induced seizures. Even as interest in Panx1 channels is burgeoning, some of their basic properties, mechanisms of modulation, and proposed functions remain controversial, with recent reports challenging some long-held views regarding Panx1 channels. In this brief review, we summarize some well-established features of Panx1 channels; we then address some current confounding issues surrounding Panx1 channels, especially with respect to intrinsic channel properties, in order to raise awareness of these unsettled issues for future research.
- Channels (Austin, Tex.).Channels (Austin).2014 Jan 13;8(2). [Epub ahead of print]
- Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, io
- PMID 24419036
- Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain.
- Rothwell SW, Stansfeld PJ, Bragg L, Verkhratsky A, North RA.Author information From the Faculty of Life Sciences and.AbstractThe ionic pore of the P2X receptor passes through the central axis of six transmembrane (TM) helices, two from each of three subunits. Val(48) and Ile(328) are at the outer end of TM1 and TM2, respectively. Homology models of the open and closed states of P2X2 indicate that pore opening is associated with a large lateral displacement of Ile(328). In addition, molecular dynamics simulations suggest that lipids enter the interstices between the outer ends of the TM domains. The P2X2(I328C) receptor was activated by propyl-methanethiosulfonate (MTS) as effectively as by ATP, but cysteine substitutions elsewhere in TM2 had no such effect. Other lipophilic MTS compounds (methyl, ethyl, and tert-butylethyl) had a similar effect but not polar MTS. The properties of the conducting pathway opened by covalent attachment of propyl-MTS were the same as those opened by ATP, with respect to unitary conductance, rectification, and permeability of N-methyl-d-glucamine. The ATP-binding residue Lys(69) was not required for the action of propyl-MTS, although propyl-MTS did not open P2X2(K308A/I328C) receptors. The propyl-MTS did not open P2X2 receptors in which the Val(48) side chain was removed (P2X2(V48G/I328C)). The results suggest that an interaction between Val(48) and Ile(328) stabilizes the closed channel and that this is broken by covalent attachment of a larger lipophilic moiety at the I328C receptors. Lipid intercalation between the separating TM domains during channel opening would be facilitated in P2X2(I328C) receptors with attached propyl-MTS. The results are consistent with the channel opening mechanism proposed on the basis of closed and open crystal structures and permit the refinement of the position of the TMs within the bilayer.
- The Journal of biological chemistry.J Biol Chem.2014 Jan 10;289(2):618-26. doi: 10.1074/jbc.M113.529099. Epub 2013 Nov 22.
- The ionic pore of the P2X receptor passes through the central axis of six transmembrane (TM) helices, two from each of three subunits. Val(48) and Ile(328) are at the outer end of TM1 and TM2, respectively. Homology models of the open and closed states of P2X2 indicate that pore opening is associate
- PMID 24273165
- Ethanol-mediated relaxation of guinea pig urinary bladder smooth muscle: involvement of BK and L-type Ca2+ channels.
- Malysz J, Afeli SA, Provence A, Petkov GV.Author information Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina.AbstractMechanisms underlying ethanol (EtOH)-induced detrusor smooth muscle (DSM) relaxation and increased urinary bladder capacity remain unknown. We investigated whether the large conductance Ca(2+)-activated K(+) (BK) channels or L-type voltage-dependent Ca(2+) channels (VDCCs), major regulators of DSM excitability and contractility, are targets for EtOH by patch-clamp electrophysiology (conventional and perforated whole cell and excised patch single channel) and isometric tension recordings using guinea pig DSM cells and isolated tissue strips, respectively. EtOH at 0.3% vol/vol (~50 mM) enhanced whole cell BK currents at +30 mV and above, determined by the selective BK channel blocker paxilline. In excised patches recorded at +40 mV and ~300 nM intracellular Ca(2+) concentration ([Ca(2+)]), EtOH (0.1-0.3%) affected single BK channels (mean conductance ~210 pS and blocked by paxilline) by increasing the open channel probability, number of open channel events, and open dwell-time constants. The amplitude of single BK channel currents and unitary conductance were not altered by EtOH. Conversely, at ~10 μM but not ~2 μM intracellular [Ca(2+)], EtOH (0.3%) decreased the single BK channel activity. EtOH (0.3%) affected transient BK currents (TBKCs) by either increasing frequency or decreasing amplitude, depending on the basal level of TBKC frequency. In isolated DSM strips, EtOH (0.1-1%) reduced the amplitude and muscle force of spontaneous phasic contractions. The EtOH-induced DSM relaxation, except at 1%, was attenuated by paxilline. EtOH (1%) inhibited L-type VDCC currents in DSM cells. In summary, we reveal the involvement of BK channels and L-type VDCCs in mediating EtOH-induced urinary bladder relaxation accommodating alcohol-induced diuresis.
- American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2014 Jan 1;306(1):C45-58. doi: 10.1152/ajpcell.00047.2013. Epub 2013 Oct 23.
- Mechanisms underlying ethanol (EtOH)-induced detrusor smooth muscle (DSM) relaxation and increased urinary bladder capacity remain unknown. We investigated whether the large conductance Ca(2+)-activated K(+) (BK) channels or L-type voltage-dependent Ca(2+) channels (VDCCs), major regulators of DSM e
- PMID 24153429
Japanese Journal
- Electrical and Thermoelectrical Transport Properties of Dirac Fermions through a Quantum Dot
- Aono Tomosuke
- J Phys Soc Jpn 82(8), 083703-083703-5, 2013-08-15
- … We investigate the conductance and thermopower of massless Dirac fermions through a quantum dot using a pseudogap Anderson model in a noncrossing approximation. … When the Fermi level is at the Dirac point, the conductance has a cusp where the thermopower changes its sign. … The conductance shows a peak near this transition and reaches the unitary limit at low temperatures. …
- NAID 150000107741
- Average and Second Moment of the Conductance of Randomly Coupled Chiral Channels
- Takane Yositake
- J Phys Soc Jpn 78(9), 094703-094703-9, 2009-09-15
- … We study the conductance of a spinless non-interacting electron system consisting of randomly coupled $N_{\text{R}}$ right-moving channels and $N_{\text{L}}$ left-moving channels. … This system serves as a model of disordered quantum wires with unitary symmetry. …
- NAID 150000089101
- Conductance Distribution in Disordered Quantum Wires with a Perfectly Conducting Channel(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Takane Yositake,Iwasaki Shingo,Yoshioka Yuka [他],YAMAMOTO Masayuki,WAKABAYASHI Katsunori
- Journal of the Physical Society of Japan 78(3), "034717-1"-"034717-6", 2009-03-15
- … We study the conductance of phase-coherent disordered quantum wires focusing on the case in which the number of conducting channels is imbalanced between two propagating directions. … Consequently, the dimensionless conductance does not vanish but converges to unity in the long-wire limit, indicating the absence of Anderson localization. …
- NAID 110007138854
Related Links
- ... was partially restored in the melatonin-treated animals, without alterations in the expression of channel subunits and unitary conductance. Acute treatment of melatonin had no significant effects on the BK channel activity or ...
- ... this current have been implicated in epilepsy, regulation of dopamine release, and pain plasticity. However, the unitary conductance (γ) of neuronal somatodendritic A-type K + channels composed of Kv4 pore-forming subunits ...
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| リンク元 | 「unit conductance」「単位コンダクタンス」 |
| 関連記事 | 「conductance」「unitary」 |
「unit conductance」
「単位コンダクタンス」
「conductance」
- n.
「unitary」
- adj.
- 単位の