タフトシン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/04 18:37:58」(JST)
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Tuftsin
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Identifiers |
CAS Registry Number
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9063-57-4 N |
ChemSpider |
21244387 N |
InChI
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InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14-,15+,16+/m1/s1 N
Key: IESDGNYHXIOKRW-LEOABGAYSA-N N
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InChI=1/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14-,15+,16+/m1/s1
Key: IESDGNYHXIOKRW-LEOABGAYBV
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Jmol-3D images |
Image |
MeSH |
Tuftsin |
PubChem |
24780 |
SMILES
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O=C(N[C@H](CCCNC(N)=N)C(O)=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)O
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UNII |
QF5336J16C Y |
Properties |
Chemical formula
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C21H40N8O6 |
Molar mass |
500.593 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) |
Infobox references |
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Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) produced by enzymatic cleavage of the Fc-domain of the heavy chain of immunoglobulin G. It is produced primarily in the spleen.
Contents
- 1 Function
- 2 Pathology
- 3 Clinical significance
- 4 History
- 5 References
- 6 See also
Function
Its biological activity is related primarily to the immune system function.
Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation.
Pathology
Tuftsin deficiency, either hereditary or following splenectomy, results in increased susceptibility to certain infections e.g.: caused by capsulated organisms as: H. influenza, pneumococci, meningococci and salmonella.[1]
Clinical significance
Tuftsin has been chemically synthesized and it is considered for use in immunotherapy.
History
Tuftsin was first identified in 1970 by scientists Najjar and Nishioka.[2] It was named after Tufts University where the peptide was discovered.
References
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 191150 - "Tuftsin deficiency"
- ^ Najjar V, Nishioka K (1970). ""Tuftsin": a natural phagocytosis stimulating peptide" (abstract page). Nature 228 (5272): 672–3. doi:10.1038/228672a0. PMID 4097539.
See also
UpToDate Contents
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English Journal
- New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocyte-derived dendritic cells.
- Wardowska A, Dzierzbicka K, Menderska A, Trzonkowski P.SourceLaboratory of Clinical Immunology and Transplantology, Medical University of Gdansk, Poland.
- Protein and peptide letters.Protein Pept Lett.2013 Feb;20(2):200-4.
- Muramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little
- PMID 22894158
- Enhanced immune response induced by a potential influenza A vaccine based on branched M2e polypeptides linked to tuftsin.
- Liu X, Guo J, Han S, Yao L, Chen A, Yang Q, Bo H, Xu P, Yin J, Zhang Z.SourceInstitute for Viral Disease Control and Prevention, China CDC, Changbai Road 155, Beijing, 102206, China.
- Vaccine.Vaccine.2012 Oct 12;30(46):6527-33. doi: 10.1016/j.vaccine.2012.08.054. Epub 2012 Sep 7.
- Vaccination is the most effective means for preventing influenza-associated morbidity and mortality. Since the influenza virus mutates frequently, the virus strains for new vaccine production should be changed according to predicted epidemic strains. The extracellular domain of matrix protein 2 (M2e
- PMID 22959982
- Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice.
- Khan MA, Aljarbou A, Khan A, Owais M.SourceInterdisciplinary Biotechnology Unit, Aligarh Muslim University, India.
- FEMS immunology and medical microbiology.FEMS Immunol Med Microbiol.2012 Oct;66(1):88-97. doi: 10.1111/j.1574-695X.2012.00992.x. Epub 2012 Jul 11.
- Cryptococcus neoformans infection is a common fungal infection in persons infected with human immune deficiency virus (HIV) or those with defective cell-mediated immunity. Since treatment of cryptococcal meningitis poses a big challenge, the present study aimed to develop a novel liposomal therapeut
- PMID 22612788
Japanese Journal
- Impaired tuftsin activity in cirrhosis : relationship with splenic function and clinical outcome
- Potentiation of Immune Response against the RESA Peptides of <i>Plasmodium falciparum</i> by Incorporating a Universal T-Cell Epitope (CS. T3) and an Immunomodulator (Polytuftsin), and Delivery through Liposomes
- ADP-ribosylation of tuftsin suppresses receptor-binding and phagocytosis-stimulating activity to murine peritoneal macrophages
Related Links
- tuftsin [tuft´sin] a tetrapeptide cleaved from IgG that stimulates phagocytosis by neutrophils. It is produced primarily in the spleen; hereditary tuftsin deficiency and tuftsin deficiency following splenectomy result in increased ...
- Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) that is a part of specific leukophilic γ-globulin termed leukokinin.1 It represents residues 289–292 of the heavy chain of γ-globulin.
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