UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 常染色体優性多発性嚢胞腎の遺伝学および嚢胞成長のメカニズム genetics of autosomal dominant polycystic kidney disease and mechanisms of cyst growth

English Journal

Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo.

Atsuta Y, Tadokoro R, Saito D, Takahashi Y.SourceDepartment of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto, 606-8502, Japan; Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, 630-0192, Japan.
Development, growth & differentiation.Dev Growth Differ.2013 Apr 4. doi: 10.1111/dgd.12047. [Epub ahead of print]
Deciphering how the tubulogenesis is regulated is an essential but unsolved issue in developmental biology. Here, using Wolffian duct (WD) formation in chicken embryos, we have developed a novel method that enables gene manipulation during tubulogenesis in vivo. Exploiting that WD arises from a defi
PMID 23550588

De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.

Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM 3rd, Reichardt LF, Marciano DK.SourceDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Development (Cambridge, England).Development.2013 Apr;140(8):1774-84. doi: 10.1242/dev.087957. Epub 2013 Mar 13.
A fundamental process in biology is the de novo formation and morphogenesis of polarized tubules. Although these processes are essential for the formation of multiple metazoan organ systems, little is known about the molecular mechanisms that regulate them. In this study, we have characterized sever
PMID 23487309

Aquaporin-1 plays a crucial role in estrogen-induced tubulogenesis of vascular endothelial cells.

Zou LB, Shi S, Zhang RJ, Wang TT, Tan YJ, Zhang D, Fei XY, Ding GL, Gao Q, Chen C, Hu XL, Huang HF, Sheng JZ.SourceMD, PhD, Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China. shengjz@zju.edu.cn.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2013 Apr;98(4):E672-82. doi: 10.1210/jc.2012-4081. Epub 2013 Feb 28.
Context: Aquaporin-1 (AQP1) has been proposed as a mediator of estrogen-induced angiogenesis in human breast cancer and endometrial cancer. Elucidation of the molecular mechanisms governing AQP1-mediated, estrogen-induced angiogenesis may contribute to an improved understanding of tumor development.
PMID 23450058