WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/03 21:33:14」(JST)

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Triclofos is a sedative drug used rarely for treating insomnia, usually as a second-line treatment after other drugs have failed. Triclofos may cause dependence and should not be withdrawn suddenly. This drug should only be used for the short term relief of severe insomnia and should not be mixed with alcohol or other depressant drugs. Patients should not drive or use machinery after taking triclofos.

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. This delayed action means that the half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Side effects

Side effects may include: headache, rash, dizziness, flatulence, confusion, nightmares, dependence, diarrhoea, constipation, nausea, vomiting, abdominal pain, and ataxia.

References

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1. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
2. 急性腎障害（急性腎不全）におけるナトリウム（FENa）、尿素（FEUrea）、およびその他分子の排泄率 fractional excretion of sodium urea and other molecules in acute kidney injury acute renal failure
3. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
4. 低ナトリウム血症を有する成人の評価 evaluation of adults with hyponatremia
5. 成人における体液量減少の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of volume depletion in adults

English Journal

Multilocalized non-pigmenting fixed drug eruption caused by triclofos sodium.

Fujimoto W, Matsuo-Kanda A.
European journal of dermatology : EJD.Eur J Dermatol.2014 Apr 11. [Epub ahead of print]
PMID 24721678

Transient administration of triclofos sodium is helpful in minimizing anticonvulsants under polypharmacy.

Sakai H, Kirino E, Inoue R, Arai H.
Psychiatry and clinical neurosciences.Psychiatry Clin Neurosci.2006 Dec;60(6):776-7.
PMID 17109718

A pediatric sedation/anesthesia program with dedicated care by anesthesiologists and nurses for procedures outside the operating room.

Gozal D1, Drenger B, Levin PD, Kadari A, Gozal Y.
The Journal of pediatrics.J Pediatr.2004 Jul;145(1):47-52.
OBJECTIVE: To examine the performance of a pediatric sedation team working according to a specific protocol and to assess parental satisfaction with the service.STUDY DESIGN: A descriptive observational study of all procedures performed by the sedation team (comprising sedation-trained pediatric int
PMID 15238906

Japanese Journal

<資料>外来で心エコー検査のため入眠処置を受ける乳幼児の睡眠リズムへの影響

佐原彩香,石川眞里子
山梨大学看護学会誌 10(1), 29-35, 2011
NAID 110008917832

こどものあざに対するレーザー治療

馬場直子
日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine 27(4), 297-302, 2007-01-15
15歳以下の小児385例，主に6歳以下の乳幼児を対象に血管腫・メラニン増殖性疾患のレーザー治療を行った．こどものレーザー治療は，リドカインクリーム，トリクロリールシロップ，エスクレ座薬などを用いて，できる限り全身麻酔をかけずに，局所麻酔だけで行うことが望ましいと思われた．<BR>ポートワイン母斑に対するダイレーザー治療は，年齢が若いほど有効で，生後2週目から治療は可能であった．部位別で …
NAID 10018697516

抱水クロラールシロップの調製法と味の改善

岡井彰男,五十崎俊介,山口巧,田中守,池川嘉郎,末大克矢,荒木博陽
医療薬学 30(1), 27-30, 2004-01-10
… Triclofos sodium syrup (Tricloryl^[○!R] syrup) is mainly used for pretreatment in EEG examinations and sedation before CT and MRI. … As we had also experienced difficulties in obtaining sufficient supplies of this medicine for a few months, we prepared a chloral hydrate syrup in our hospital as a substitute for triclofos sodium syrup, aiming to reduce the unpleasant taste and smell of chloral hydrate in the process. …
NAID 110001166768

Related Pictures

★リンクテーブル★

リンク元	「トリクロホス」「トリクロホスナトリウム」
関連記事	「triclofos」

「トリクロホス」

Triclofos
Systematic (IUPAC) name
	2,2,2-trichloroethanol dihydrogen phosphate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	306-52-5 8060-81-9
ATC code	N05CM07 (WHO)
PubChem	CID 5563
ChemSpider	5362
UNII	J712EO9048
ChEMBL	CHEMBL1201317
Chemical data
Formula	C2H4Cl3O4P
Molar mass	229.383 g/mol
	SMILES ClC(Cl)(Cl)COP(=O)(O)O ;
	InChI InChI=1S/C2H4Cl3O4P/c3-2(4,5)1-9-10(6,7)8/h1H2,(H2,6,7,8) ; Key:YYQRGCZGSFRBAM-UHFFFAOYSA-N ;
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