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1. 表皮水疱症のマネージメントの概要 overview of the management of epidermolysis bullosa
2. 鎌状赤血球症に対するヒドロキシ尿素治療または疾患修飾療法 hydroxyurea and other disease modifying therapies in sickle cell disease
3. 成人における急性前骨髄球性白血病の初期治療 initial treatment of acute promyelocytic leukemia in adults
4. 再発性および難治性の急性前骨髄球性白血病の治療 treatment of relapsed or refractory acute promyelocytic leukemia in adults
5. 食事中の脂肪 dietary fat

English Journal

Segmental expression and C-terminal labeling of protein ERp44 through protein trans-splicing.

Dai X1, Liu XQ2, Meng Q3.
Protein expression and purification.Protein Expr Purif.2015 Aug;112:29-36. doi: 10.1016/j.pep.2015.04.005. Epub 2015 Apr 20.
Endoplasmic reticulum resident protein 44 (ERp44) is a member of the protein disulfide isomerase family and functions in oxidative protein folding in the endoplasmic reticulum. A structurally flexible C-terminal tail (C-tail) of ERp44 plays critical roles in dynamically regulating ERp44's function i
PMID 25907381

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.

Amini ZN1, Müller UF1.
RNA (New York, N.Y.).RNA.2015 Aug;21(8):1480-9. doi: 10.1261/rna.051888.115. Epub 2015 Jun 23.
The group I intron ribozyme from Tetrahymena was recently reengineered into a trans-splicing variant that is able to remove 100-nt introns from pre-mRNA, analogous to the spliceosome. These spliceozymes were improved in this study by 10 rounds of evolution in Escherichia coli cells. One clone with i
PMID 26106216

Splicing remodels the let-7 primary microRNA to facilitate Drosha processing in Caenorhabditis elegans.

Mondol V1, Ahn BC1, Pasquinelli AE1.
RNA (New York, N.Y.).RNA.2015 Aug;21(8):1396-403. doi: 10.1261/rna.052118.115. Epub 2015 Jun 16.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that use partial base-pairing to recognize and regulate the expression of messenger RNAs (mRNAs). Mature miRNAs arise from longer primary transcripts (pri-miRNAs) that are processed to a shorter hairpin precursor miRNA (pre-miRNA) by the Micropr
PMID 26081559