シヌクレイン、シヌクリン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/29 02:33:45」(JST)
[Wiki en表示]
Synuclein |
Identifiers |
Symbol |
Synuclein |
Pfam |
PF01387 |
InterPro |
IPR001058 |
SCOP |
1xq8 |
SUPERFAMILY |
1xq8 |
OPM superfamily |
159 |
OPM protein |
1xq8 |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe; PDBj |
PDBsum |
structure summary |
|
Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors.[1]
Contents
- 1 Family members
- 2 Function
- 3 Human proteins containing this domain
- 4 References
- 5 External links
Family members
The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began when alpha-synuclein was found to be mutated in several families with autosomal dominant Parkinson's disease.[2]
All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Synuclein family members are not found outside vertebrates, although they have some conserved structural similarity with plant 'late-embryo-abundant' proteins.[1]
- Alpha-synuclein IPR002460
- Beta-synuclein IPR002461
- Gamma-synuclein IPR002462
Function
Normal cellular functions have not been determined for any of the synuclein proteins. Some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with early-onset familial Parkinson's disease and the protein aggregates abnormally in Parkinson's disease, Alzheimer's disease, Lewy body disease, and other neurodegenerative diseases.[3][4] The gamma-synuclein protein's expression in breast tumors is a marker for tumor progression.[5][6]
Human proteins containing this domain
SNCA; SNCB; SNCG;
References
- ^ a b George JM (2002). "The synucleins". Genome Biol. 3 (1): REVIEWS3002. doi:10.1186/gb-2001-3-1-reviews3002. PMC 150459. PMID 11806835.
- ^ Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A et al. (1997). "Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.". Science 276 (5321): 2045–7. doi:10.1126/science.276.5321.2045. PMID 9197268.
- ^ Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998). "Alpha synuclein in neurodegenerative disorders: murderer or accomplice?". Nat Med 4 (7): 755–7. doi:10.1038/nm0798-755. PMID 9662355.
- ^ Goedert M (July 2001). "Alpha-synuclein and neurodegenerative diseases". Nat. Rev. Neurosci. 2 (7): 492–501. doi:10.1038/35081564. PMID 11433374.
- ^ Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G et al. (1997). "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.". Cancer Res 57 (4): 759–64. PMID 9044857.
- ^ Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK (May 2000). "Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary". Cancer 88 (9): 2154–63. doi:10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9. PMID 10813729.
External links
- Synucleins at the US National Library of Medicine Medical Subject Headings (MeSH)
Protein: nerve tissue protein
|
|
Synuclein |
- Alpha-synuclein
- Beta-synuclein
- Gamma-synuclein
|
|
Other |
- Agrin
- Chimerin
- Granin
- FMR1
- Gap-43 protein
- GLUT3
- Myelin
- Brain natriuretic peptide
- Nerve growth factor
- SCG5
- Neurogranin
- Neuronal calcium sensor
- Neuropeptide
- Olfactory marker protein
- S100 protein
- Synapsin
- Synaptophysin
- Tubulin
- GPM6A
|
|
Index of the central nervous system
|
|
Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
|
|
Disease |
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
|
|
Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- addiction
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
|
Index of the peripheral nervous system
|
|
Description |
- Anatomy
- Nerves
- cranial
- trigeminal
- cervical
- brachial
- lumbosacral plexus
- somatosensory
- spinal
- autonomic
- Physiology
- reflexes
- proteins
- neurotransmitters
- transporters
- Development
|
|
Disease |
- Autonomic
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Local anesthetics
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Environment-contact administration of rotenone: A new rodent model of Parkinson's disease.
- Liu Y1, Sun JD1, Song LK1, Li J1, Chu SF2, Yuan YH1, Chen NH3.
- Behavioural brain research.Behav Brain Res.2015 Nov 1;294:149-61. doi: 10.1016/j.bbr.2015.07.058. Epub 2015 Jul 31.
- Epidemiological studies suggest an association between pesticides and the incidence of Parkinson's disease (PD). Individuals are likely to be exposed to numerous natural or synthetic environmental agents by ingestion, inhalation, or skin contact. Here, we describe a novel environment-contact adminis
- PMID 26239001
- Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease.
- Grant LM1,2, Kelm-Nelson CA1, Hilby BL2, Blue KV2, Paul Rajamanickam ES2, Pultorak JD3, Fleming SM4, Ciucci MR1,2,5.
- Journal of neuroscience research.J Neurosci Res.2015 Nov;93(11):1713-27. doi: 10.1002/jnr.23625. Epub 2015 Jul 31.
- Parkinson's disease (PD) is a progressive neurodegenerative disease that leads to a wide range of motor and nonmotor deficits. Specifically, voice and swallow deficits manifest early, are devastating to quality of life, and are difficult to treat with standard medical therapies. The pathological hal
- PMID 26234713
- Alpha-linolenic acid suppresses dopaminergic neurodegeneration induced by 6-OHDA in C. elegans.
- Shashikumar S1, Pradeep H1, Chinnu S2, Rajini PS2, Rajanikant GK3.
- Physiology & behavior.Physiol Behav.2015 Nov 1;151:563-9. doi: 10.1016/j.physbeh.2015.08.025. Epub 2015 Aug 20.
- Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the specific and massive loss of dopamine (DA) containing neurons in the substantia nigra pars compacta (SNpc) and aggregation of protein α-synuclein. There are a few animal studies, which indirectly impl
- PMID 26300470
Japanese Journal
- Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein.
- Uemura Norihito,Koike Masato,Ansai Satoshi,Kinoshita Masato,Ishikawa-Fujiwara Tomoko,Matsui Hideaki,Naruse Kiyoshi,Sakamoto Naoaki,Uchiyama Yasuo,Todo Takeshi,Takeda Shunichi,Yamakado Hodaka,Takahashi Ryosuke
- PLOS genetics 11(4), 2015-04-02
- … Detailed pathological findings represented lysosomal abnormalities in neurons and alpha-synuclein (α-syn) accumulation in axonal swellings containing autophagosomes. …
- NAID 120005593596
- Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human α-synuclein
- Wijayanti Indah,Watanabe Daisuke,Oshiro Satoshi [他]
- The journal of biochemistry 157(4), 251-260, 2015-04
- NAID 40020428775
- パーキンソン病におけるαシヌクレイン病変のプリオン様伝播
Related Links
- Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown ...
- Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors. Contents. 1 Family members; 2 Function; 3 Human proteins containing this domain; 4 References; 5 External links ...
Related Pictures
★リンクテーブル★
[★]
- 英
- synuclein
- 関
- シヌクレイン
[★]
- 英
- synuclein
- 関
- シヌクリン