シントロフィン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/12 11:05:16」(JST)
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The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in the Torpedo electric organ (originally called "58K protein"). Subsequently, α-syntrophin was shown to be the predominant isoform in skeletal muscle where it is localized on the sarcolemma and enriched at the neuromuscular junction. The β-syntrophins and γ2-syntrophin are also present in skeletal muscle but also are in most other tissues. The expression of γ1-syntrophin is mostly confined to brain. The syntrophins are adapter proteins that use their multiple protein interaction domains (two pleckstrin homology domains and a PDZ domain) to localize a variety of signaling proteins (kinases, ion channels, water channels, nitric oxide synthase) to specific intracellular locations. α-Syntrophin binds to nNOS in the dystrophin-associated glycoprotein complex in skeletal muscle cells. There it produces NO upon muscle contraction leading to dilation of the arteries in the local area.[1]
References
- ^ http://jcs.biologists.org/content/117/13/2627.full.pdf
External links
- syntrophin at the US National Library of Medicine Medical Subject Headings (MeSH)
Histology: muscle tissue (TH H2.00.05, H3.3)
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Smooth
muscle |
- Calmodulin
- Vascular smooth muscle
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Striated
muscle |
Skeletal
muscle |
Costamere/
DAPC |
Membrane/
extracellular |
DAP: |
- Sarcoglycan
- SGCA
- SGCB
- SGCD
- SGCE
- SGCG
- SGCZ
- Dystroglycan
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- Sarcospan
- Laminin, alpha 2
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Intracellular |
- Dystrophin
- Dystrobrevin
- Syntrophin
- Syncoilin
- Dysbindin
- Synemin/desmuslin
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related: |
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Sarcomere/
(a, i, and h bands;
z and m lines) |
- Myofilament
- thin filament/actin
- thick filament/myosin
- elastic filament/titin
- nebulin
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Connective tissue |
- Epimysium
- Fascicle
- Perimysium
- Endomysium
- Connective tissue in skeletal muscle
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General |
- Neuromuscular junction
- Motor unit
- Muscle spindle
- Excitation–contraction coupling
- Sliding filament mechanism
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Cardiac
muscle |
- Myocardium
- Intercalated disc
- Nebulette
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Both |
Fiber |
- Muscle fiber
- Myofibril
- Microfilament/Myofilament
- Sarcomere
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Cells |
- Myoblast/Myocyte
- Myosatellite cell
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Other |
- Desmin
- Sarcoplasm
- Sarcolemma
- Sarcoplasmic reticulum
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Other/
ungrouped |
- Myotilin
- Telethonin
- Dysferlin
- Fukutin
- Fukutin-related protein
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English Journal
- Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.
- Hebel T1, Eisinger K1, Neumeier M1, Rein-Fischboeck L1, Pohl R1, Meier EM1, Boettcher A2, Froehner SC3, Adams ME3, Liebisch G2, Krautbauer S1, Buechler C4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 May;1851(5):527-36. doi: 10.1016/j.bbalip.2015.01.012. Epub 2015 Jan 24.
- The syntrophins alpha (SNTA) and beta 2 (SNTB2) are molecular adaptor proteins shown to stabilize ABCA1, an essential regulator of HDL cholesterol. Furthermore, SNTB2 is involved in glucose stimulated insulin release. Hyperglycemia and dyslipidemia are characteristic features of the metabolic syndro
- PMID 25625330
- Protein Assemblies of Sodium and Inward Rectifier Potassium Channels Control Cardiac Excitability and Arrhythmogenesis.
- Willis BC1, Ponce-Balbuena D1, Jalife J2.
- American journal of physiology. Heart and circulatory physiology.Am J Physiol Heart Circ Physiol.2015 Apr 10:ajpheart.00176.2015. doi: 10.1152/ajpheart.00176.2015. [Epub ahead of print]
- The understanding of how cardiac ion channels function in the normal and the diseased heart has greatly increased over the last four decades thanks to the advent of patch-clamp technology and, more recently, the emergence of genetics as well as cellular and molecular cardiology. However, our knowled
- PMID 25862830
- Correction: altered astrocytic swelling in the cortex of α-syntrophin-negative GFAP/EGFP mice.
- PLOS ONE Staff.
- PloS one.PLoS One.2015 Mar 16;10(3):e0119744. doi: 10.1371/journal.pone.0119744. eCollection 2015.
- PMID 25775461
Japanese Journal
- Functional Abnormality of Sodium Channel Interacting Proteins in Arrhythmogenesis
- C. Makielski Jonathan
- Journal of Arrhythmia 27(Supplement), SS3_1, 2011
- … encoding syntrophin α1 as a cause of LQTS (LQT12). …
- NAID 130002130110
- Immunocytochemical Studies of Aquaporin 4, Kir4.1, and .ALPHA.1-syntrophin in the Astrocyte Endfeet of Mouse Brain Capillaries
- Masaki Hisatsugu,Wakayama Yoshihiro,Hara Hajime,Jimi Takahiro,Unaki Akihiko,Iijima Shoji,Oniki Hiroaki,Nakano Kiyoko,Kishimoto Koji,Hirayama Yoshiko
- ACTA HISTOCHEMICA ET CYTOCHEMICA 43(4), 99-105, 2010
- … We examined the ultrastructural localization of Kir4.1, AQP4, α1-syntrophin, and β-spectrin molecules to understand the functional role(s) of Kir4.1 and AQP4. … Double immunogold electron microscopy showed frequent co-localization in the combination of molecules of Kir4.1 and AQP4, Kir4.1 and α1-syntrophin, and AQP4 and α1-syntrophin, but not those of AQP4 and β-spectrin. …
- NAID 130000300030
- SKELETAL MUSCLE SYNTROPHIN INTERACTORS REVEALED BY YEAST TWO-HYBRID ASSAY
- Inoue Masahiko,Wakayama Yoshihiro,Jimi Takahiro,Shibuya Seiji,Hara Hajime,Unaki Akihiko,Kenmochi Kiyokazu
- Nagoya Journal of Medical Science 70(3/4), 117-126, 2008-08
- NAID 110007020072
Related Links
- Syntrophin, alpha 1とは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Syntrophin, alpha 1とは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ 本文へ ...
- alpha-Syntrophin Antibody (N-19) is a goat polyclonal recommended for detecting alpha-Syntrophin of mouse, rat and human origin by WB, IP, IF and ELISA ... Every item is shipped based on the best shipping method assessed for ...
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