synthetic vascular graft

人工血管

WordNet

1. cause to grow together parts from different plants; "graft the cherry tree branch onto the plum tree" (同)engraft, ingraft
2. the act of grafting something onto something else (同)grafting
3. (surgery) tissue or organ transplanted from a donor to a recipient; in some cases the patient can be both donor and recipient (同)transplant
4. systematic combining of root and modifying elements into single words
5. a compound made artificially by chemical reactions (同)synthetic substance
6. involving or of the nature of synthesis (combining separate elements to form a coherent whole) as opposed to analysis; "limnology is essentially a synthetic science composed of elements...that extend well beyond the limits of biology"- P.S.Welch (同)synthetical
7. of a proposition whose truth value is determined by observation or facts; "`all men are arrogant is a synthetic proposition" (同)synthetical
8. not genuine or natural; "counterfeit rhetoric that flourishes when passions are synthetic"- George Will
9. of or relating to or having vessels that conduct and circulate fluids; "vascular constriction"; "a vascular bundle"

PrepTutorEJDIC

1. (つぎ木の)つぎ穂;つぎ木 / (皮被・内臓・骨などの)移植片 / (木に)〈つぎ穂〉‘を'つぐ,(体に)〈移植片〉‘を'移植する《+『名』+『on』(『upon』,『in』,『into』)+『名』》 / …‘を'結合させる《+『名』+『together』》 / (…に)つぎ木する,移植する《+『on』(『upon』,『in』,『into』)+『名』》
2. 収賄,汚職;贈賄;〈C〉汚職で得たもの / 汚職する,収賄する
3. 総合の,統合的な / 合成の,人造の / にせの,作りごとの / (言語が)総合的な(統語的関係を表すのに,独立した語より屈折形を広く用いるもの) / 合成品,人造物
4. (血液・樹液などを運ぶ)管の,導管の,血管の

UpToDate Contents

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• 1. 下肢跛行患者の手術の適応 indications for surgery in the patient with lower extremity claudication
• 2. 腹部大動脈瘤の血管内修復 endovascular repair of abdominal aortic aneurysm
• 3. 下肢の慢性重症下肢虚血の治療 treatment of chronic lower extremity critical limb ischemia
• 4. 冠動脈バイパス術後の長期転帰 long term outcome after coronary artery bypass graft surgery
• 5. 大伏在静脈グラフトの狭窄の予防、症状、およびマネージメント prevention presentation and management of saphenous vein graft stenosis

English Journal

• Effect of sustained heparin release from PCL/chitosan hybrid small-diameter vascular grafts on anti-thrombogenic property and endothelialization.

• Yao Y1, Wang J2, Cui Y2, Xu R3, Wang Z2, Zhang J3, Wang K2, Li Y3, Zhao Q4, Kong D5.Author information 1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China; Center for Advanced Materials and Biotechnology, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, People's Republic of China.2State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China.3Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin 300192, People's Republic of China.4State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China. Electronic address: qiangzhao@nankai.edu.cn.5State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China; Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin 300192, People's Republic of China.AbstractThrombus formation and subsequent occlusion are the main reasons for the failure of small-diameter vascular grafts. In this study, a hybrid small-diameter vascular graft was developed from synthetic polymer poly(ε-caprolactone) (PCL) and natural polymer chitosan (CS) by the co-electrospinning technique. Heparin was immobilized on the grafts through ionic bonding between heparin and CS fibers. The immobilization was relatively stable, and heparin could continuously release from the grafts for more than 1month. Heparin functionalization evidently improved the hemocompatibility of the PCL/CS vascular grafts, which was illustrated by the reduced platelet adhesion and prolonged coagulation time (activated partial thromboplastin time, prothrombin time and thromboplastin time) as shown in the human plasma assay, and was further confirmed by the ex vivo arteriovenous shunt experiment. In vitro cell proliferation assay showed that heparin can promote the growth of human umbilical vein endothelial cells, while moderately inhibiting the proliferation of vascular smooth muscle cells, a main factor for neointimal hyperplasia. Implantation in rat abdominal aorta was performed for 1month. Results indicate that sustained release of heparin provided optimal anti-thrombogenic effect by reducing thrombus formation and maintaining the patency. Furthermore, heparin functionalization also enhanced in situ endothelialization, thereby preventing the occurrence of restenosis. In conclusion, it provides a facile and useful technique for the development of heparinized medical devices, including vascular grafts.
• Acta biomaterialia.Acta Biomater.2014 Jun;10(6):2739-2749. doi: 10.1016/j.actbio.2014.02.042. Epub 2014 Mar 4.
• Thrombus formation and subsequent occlusion are the main reasons for the failure of small-diameter vascular grafts. In this study, a hybrid small-diameter vascular graft was developed from synthetic polymer poly(ε-caprolactone) (PCL) and natural polymer chitosan (CS) by the co-electrospinning techn
• PMID 24602806

• Development and assessment of a biodegradable solvent cast polyester fabric small-diameter vascular graft.

• Melchiorri AJ1, Hibino N, Brandes ZR, Jonas RA, Fisher JP.Author information 1Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, 20742.AbstractAdjusting the mechanical properties of polyester-based vascular grafts is crucial to achieving long-term success in vivo. Although previous studies using a fabric-based approach have achieved some success, a central issue with pure poly(lactic acid) (PLA) or poly(glycolic acid) (PGA) grafts sealed with poly(dl-caprolactone-co-lactic acid) (P(CL/LA)) has been stenosis. Intimal hyperplasia, a leading cause of stenosis, can be caused by the mechanical incompatibility of synthetic vascular grafts. Investigating the performance of poly(glycolic-co-lactic acid) (PGLA) grafts could lead to insight into whether graft stenosis stems from mechanical issues such as noncompliance and unfavorable degradation times. This could be achieved by examining grafts with tunable mechanical properties between the ranges of such properties in pure PGA and PLA-based grafts. In this study, we examined PGLA-based grafts sealed with different P(CL/LA) solutions to determine the PGLA-P(CL/LA) grafts' mechanical properties and tissue functionality. Cell attachment and proliferation on graft surfaces were also observed. For in vivo assessment, grafts were implanted in a mouse model. Mechanical properties and degradation times appeared adequate compared to recorded values of vessels used in autograft procedures. Initial neotissue formation was observed in the grafts and patency maintained during the pilot study. This study presents a ∼1-mm diameter degradable graft demonstrating suitable mechanical properties and in vivo pilot study success, enabling further investigation into the tuning of mechanical properties to reduce complications in degradable polyester fabric-based vascular grafts. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1972-1981, 2014.
• Journal of biomedical materials research. Part A.J Biomed Mater Res A.2014 Jun;102(6):1972-81. doi: 10.1002/jbm.a.34872. Epub 2013 Jul 30.
• Adjusting the mechanical properties of polyester-based vascular grafts is crucial to achieving long-term success in vivo. Although previous studies using a fabric-based approach have achieved some success, a central issue with pure poly(lactic acid) (PLA) or poly(glycolic acid) (PGA) grafts sealed w
• PMID 23852776

• Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration.

• Pitarresi G1, Fiorica C, Palumbo FS, Rigogliuso S, Ghersi G, Giammona G.Author information 1Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Plesso di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy; IBIM-CNR, Via Ugo La Malfa 153, 90146, Palermo, Italy.AbstractAn interesting issue in tissue engineering is the development of a biodegradable vascular graft able to substitute a blood vessel and to allow its complete regeneration. Here, we report a new scaffold potentially useful as a synthetic vascular graft, produced through the electrospinning of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-d,l-aspartamide-graft-polylactic acid (PHEA-EDA-g-PLA) in the presence of polycaprolactone (PCL). The scaffold degradation profile has been evaluated as well as the possibility to bind heparin to electrospun fibers, being it a known anticoagulant molecule able to bind growth factors. In vitro cell compatibility has been investigated using human vascular endothelial cells (ECV 304) and the ability of heparinized PHEA-EDA-g-PLA/PCL scaffold to retain basic fibroblast growth factor has been evaluated in comparison with not heparinized sample. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1334-1341, 2014.
• Journal of biomedical materials research. Part A.J Biomed Mater Res A.2014 May;102(5):1334-41. doi: 10.1002/jbm.a.34818. Epub 2013 Jun 11.
• An interesting issue in tissue engineering is the development of a biodegradable vascular graft able to substitute a blood vessel and to allow its complete regeneration. Here, we report a new scaffold potentially useful as a synthetic vascular graft, produced through the electrospinning of α,β-pol
• PMID 23733561

Japanese Journal

• バイオエンジニアと血管外科医のコラボレーションの進め方

• 梅津 光生
• 日本血管外科学会雑誌 advpub(0), 2015
• 要旨：本稿では，筆者が手掛けた3 種類の血液循環系のシミュレータ装置を用いて血管外科領域の医工連携の研究に関して紹介する．まず，大血管を人工血管で置換する際のシミュレータの大動脈血管インピーダンス特性を求めた結果，人工血管置換後は心負荷が増大することを示す．次に，脳外科で使用されている手術ナビゲーションシステムを血管外科に応用し，Adamkiewicz 動脈につながる肋間動脈の位置特定に用いその臨 …
• NAID 130005074434

• 人工肛門造設術・永久気管孔造設術の既往歴を有する症例に発症した感染性胸部大動脈瘤の治療経験

• 常深 孝太郎,森田 雅文,吉井 康欣,三重野 繁敏
• 日本血管外科学会雑誌 23(4), 822-825, 2014
• 要旨：症例は75 歳，男性．喉頭癌に対して喉頭全摘術・永久気管孔造設術，直腸癌に対してハルトマン手術・人工肛門造設術の既往歴がある．高熱，全身倦怠感，食欲低下を主訴に救急搬送され，入院となった．精査で大腸菌を起炎菌とする感染性胸部大動脈瘤と診断された．治療は，抗生剤点滴による感染調節を行い，その後，肋間開胸・人工心肺使用下に感染した胸部大動脈の切除および上行・弓部・下行大動脈の一期的人工血管置換術 …
• NAID 130004490591

• Novel Infectious Agent-Free Hemostatic Material (TDM-621) in Cardiovascular Surgery

• , , , ,
• Annals of thoracic and cardiovascular surgery 18(5), 444-451, 2012-10-01
• … In this study, we focused on an entirely synthetic self-assembling peptide (development code: TDM-621) that gels when in contact with blood or other bodily fluids and stops bleeding upon contact with a wound site. … Twenty-five patients (22 men, 3 women) were enrolled in the clinical study, and the following procedures were performed: 1) coronary artery bypass graft (CABG) (n = 9), 2) abdominal aortic graft replacement (n = 4), and 3) peripheral artery bypass (n = 12). …
• NAID 10031120928

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★リンクテーブル★

リンク元	「人工血管」
関連記事	「graft」「vascular」「synthetic」「grafting」

「人工血管」

　　[★]

英

synthetic vascular graft, artificial blood vessel, synthetic vascular prosthesis

同

合成代用血管、代用血管 vascular prosthesis

「graft」

　　[★]

• n

• 移植片、グラフト

• v.

• 移植する、(植物)接木する

関

cell transplant、engraft、engraftment、explant、grafting、implant、implantation、organ graft、organ transplant、tissue graft、tissue transplant、transfer、transplant、transplant recipient、transplantation

　 　 　 　 　

「vascular」

　　[★]

• adj.

• (生物・解剖)導管の、脈管の、血管の

関

angio、blood vessel、fibrovascular bundle、vascular bundle、vasculogenic、vein、vessel

　 　

「synthetic」

　　[★]

• adj.

• 合成の、合成的な、総合的な

関

construction、elaboration、syntheses、synthesis、synthesize、synthetically

　 　 　 　 　 　

「grafting」

　　[★]

• n.

• 移植、移植法、移植術

関

engraft、engraftment、graft、implant、implantation、transfer、transplant、transplantation