English Journal

E- and Z-, di- and tri-substituted alkenyl nitriles through catalytic cross-metathesis.

Mu Y, Nguyen TT, Koh MJ, Schrock RR, Hoveyda AH.
Nature chemistry. 2019 Apr;().
Nitriles are found in many bioactive compounds, and are among the most versatile functional groups in organic chemistry. Despite many notable recent advances, however, there are no approaches that may be used for the preparation of di- or tri-substituted alkenyl nitriles. Related approaches that are
PMID 30936524

Application of tandem coupling of columns in supercritical fluid chromatography for stereoisomeric separation: Optimization and simulation.

Akchich A, Charton J, Lipka E.
Journal of chromatography. A. 2019 Mar;1588()115-126.
Chromatographic separation of compounds with more than one chiral center is challenging, requiring high resolution methods. Owing to the low viscosity of the mobile phase, Supercritical Fluid Chromatography (SFC) enables the tandem coupling of columns which increases resolution compared over a singl
PMID 30595432

Antidepressant-relevant concentrations of the ketamine metabolite (2,6)-hydroxynorketamine do not block NMDA receptor function.

Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD.
Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar;116(11)5160-5169.
Preclinical studies indicate that (2,6)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2,6)-HNK to inhibit
PMID 30796190

Japanese Journal

構造異性体と立体異性体の二分法の誤解

藤田眞作
Journal of Computer Chemistry, Japan 13(6), 321-322, 2015
… Misleading classification of isomeric and stereoisomeric relationships as well as the related misleading classification of isomers and stereoisomers are discussed in terms of equivalence relationships and equivalence classes, which have not been taken into consideration in the conventional terminology of modern stereochemistry. …
NAID 130004933671

Misleading Classification of Isomers and Stereoisomers in Organic Chemistry

Bulletin of the Chemical Society of Japan 87(12), 1367-1378, 2014
… The conventional definitions of an isomeric relationship, a stereoisomeric relationship, and an enantiomeric relationship are revised respectively to connote a self-isomeric relationship, a self-stereoisomeric relationship, and a self-enantiomeric relationship. …
NAID 130004703934

RS –立体異性体群と四つ組RS –立体異性体の数え上げ

藤田眞作
Journal of Computer Chemistry, Japan 13(3), 155-156, 2014
… RS-stereoisomeric group T d σ ˜ I ˆ for characterizing stereoisograms based …
NAID 130004694010

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