sizofiran

シゾフィラン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/28 14:21:46」(JST)

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Sizofiran
Other names Schizophyllan
Identifiers
CAS number	9050-67-3 N
PubChem	7848598
KEGG	D01535 Y
Properties
Molecular formula	(C6H10O5)n
Molar mass	variable
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N (verify) (what is: Y/N?)
Infobox references

Sizofiran is a beta-glucan, also known as schizophyllan and abbreviated as SPG in many papers. It is a polysaccharide consisting of repeating β(1→3)-linked D-glucose units with occasional β(1→6)-branches. This generates a very stiff triple-helical structure in water.

References

English Journal

• Antitumor activity of mushroom polysaccharides: a review.

• Ren L, Perera C, Hemar Y.SourceSchool of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
• Food & function.Food Funct.2012 Nov;3(11):1118-30. doi: 10.1039/c2fo10279j.
• Mushrooms were considered as a special delicacy by early civilizations and valued as a credible source of nutrients including considerable amounts of dietary fiber, minerals, and vitamins (in particularly, vitamin D). Mushrooms are also recognized as functional foods for their bioactive compounds of
• PMID 22865023

• Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease.

• Nishihira J.SourceDepartment of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido, Japan. nishihira@do-johodai.ac.jp
• Annals of the New York Academy of Sciences.Ann N Y Acad Sci.2012 Oct;1271:53-7. doi: 10.1111/j.1749-6632.2012.06735.x.
• Macrophage migration inhibitory factor (MIF) is a unique protein that participates in inflammation, immune responses, and cell growth. An array of in vitro and in vivo experiments has demonstrated that MIF is profoundly involved in the pathogenesis of acute and chronic inflammatory disorders, such a
• PMID 23050964

• Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen.

• Mansour A, Daba A, Baddour N, El-Saadani M, Aleem E.SourceDepartment of Zoology, Division of Molecular Biology, Faculty of Science, Alexandria University, Moharram Bey, Alexandria, 21511, Egypt.
• Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.2012 Sep;138(9):1579-96. doi: 10.1007/s00432-012-1224-0. Epub 2012 May 3.
• BACKGROUND: Breast cancer is one of the leading causes of cancer mortality among women. Some anticancer compounds have been isolated from mushrooms. The aim of the present work was to study the anticancer effects of schizophyllan (SCH), a β-D: -glucan extracted from the mushroom Schizophyllum commu
• PMID 22552717

Japanese Journal

• Graves' Disease Development During Sizofiran Treatment

• MORITA Shigeki,UEDA Yasuo
• Internal medicine 41(11), 977-978, 2002-11-01
• NAID 50000707082

• Graves' Disease Development During Sizofiran Treatment.

• MORITA Shigeki,UEDA Yasuo
• Internal Medicine 41(11), 977-978, 2002
• … We describe here a case of Graves' disease during treatment with sizofiran, an immunoactivator. … A 42-year-old woman who had previously been in an euthyroid state with Hashimoto's thyroiditis, experienced thyrotoxicosis during continuous administration of sizofiran as immunotherapy for endometrial carcinoma. … It is suggested that the administration of sizofiran may be one of the triggers of Graves' disease.(Internal Medicine 41: 977-978, 2002) …
• NAID 130000767537

• Immunohistochemical study of HLA antigens and lymphocytic infiltrations in advanced vaginel cancer regressed by adjuvant therapy with intratumoral sizofiran

• OGINO Hiroshi,HIROTA Yutaka,KADOWAKI Megumi,HATTORI Kimihiro,AOKI Toyokazu,KAWAKAMI Seiji
• International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology 3(6), 392-395, 1998-12-01
• NAID 10011137374

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