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- the granitelike rocks that form the outermost layer of the earths crust; rich in silicon and aluminum
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- 1. 成人における肺胞蛋白症の臨床症状および病因 clinical manifestations and etiology of pulmonary alveolar proteinosis in adults
- 2. 不安定プラークの病理および病因 pathology and pathogenesis of the vulnerable plaque
- 3. 好中球増多症の原因 causes of neutrophilia
- 4. 原発性免疫不全症の診断のためのフローサイトメトリー flow cytometry for the diagnosis of primary immunodeficiencies
- 5. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
English Journal
- A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides.
- Matsushita T1, Takada W2, Igarashi K2, Naruchi K3, Miyoshi R3, Garcia-Martin F1, Amano M4, Hinou H4, Nishimura S5.Author information 1Field of Drug Discovery Research, Faculty of Advanced Life Science, Hokkaido University, N22, W11 Kita-ku, Sapporo 001-0021, Japan.2Sumitomo Bakelite Co., Ltd., Tokyo, Japan.3Medicinal Chemistry Pharmaceuticals, Co. Ltd., N22, W12, Kita-ku, Sapporo 001-0021, Japan.4Field of Drug Discovery Research, Faculty of Advanced Life Science, Hokkaido University, N22, W11 Kita-ku, Sapporo 001-0021, Japan; Medicinal Chemistry Pharmaceuticals, Co. Ltd., N22, W12, Kita-ku, Sapporo 001-0021, Japan.5Field of Drug Discovery Research, Faculty of Advanced Life Science, Hokkaido University, N22, W11 Kita-ku, Sapporo 001-0021, Japan; Medicinal Chemistry Pharmaceuticals, Co. Ltd., N22, W12, Kita-ku, Sapporo 001-0021, Japan. Electronic address: shin@sci.hokudai.ac.jp.AbstractBACKGROUND: Human serum MUC1 peptide fragments bearing aberrant O-glycans are secreted from columnar epithelial cell surfaces and known as clinically important serum biomarkers for the epithelial carcinoma when a specific monoclonal antibody can probe disease-relevant epitopes. Despite the growing importance of MUC1 glycopeptides as biomarkers, the precise epitopes of most anti-MUC1 monoclonal antibodies remains unclear.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1840(3):1105-16. doi: 10.1016/j.bbagen.2013.11.009. Epub 2013 Nov 16.
- BACKGROUND: Human serum MUC1 peptide fragments bearing aberrant O-glycans are secreted from columnar epithelial cell surfaces and known as clinically important serum biomarkers for the epithelial carcinoma when a specific monoclonal antibody can probe disease-relevant epitopes. Despite the growing i
- PMID 24246952
- A comparison of the main structures of N-glycans of porcine islets with those from humans.
- Miyagawa S, Maeda A, Kawamura T, Ueno T, Usui N, Kondo S, Matsumoto S, Okitsu T, Goto M, Nagashima H.Author information Division of Organ Transplantation, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.AbstractAfter producing α1-3-galactosyltransferase knockout (GKO) pigs, most of the organs of these pigs showed less antigenicity to the human body. However, wild-type adult pig islets (API) that originally contained negligible levels of α-galactosidase now showed a clear antigenicity to human serum. In this study, N-glycans were isolated from both APIs and human islets. Their structures were then analyzed by a mapping technique based on their high-performance liquid chromatography elution positions and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometric data. Both preparations contained substantial amounts of high-mannose structures. The N-glycans from human islets were separated into 17 neutral, 8 mono-sialyl and 4 di-sialyl glycans, and the API glycans were comprised of 11 neutral, 8 mono-sialyl, 3 di-sialyl, 2 mono-sulfated, 3 mono-sialyl-mono-sulfated and 1 di-sulfated glycans. Among them, the API preparation contained one neutral, five mono-sialyl glycans and six sulfated glycans that were not detected in human islets. The structures of 9 of these 12 could be clearly determined. In addition, a study of the sulfate-depleted API suggests that sulfate residues could be antigenic to humans. The data herein will be helpful for future studies of the antigenicity associated with API.
- Glycobiology.Glycobiology.2014 Feb;24(2):125-38. doi: 10.1093/glycob/cwt088. Epub 2013 Oct 7.
- After producing α1-3-galactosyltransferase knockout (GKO) pigs, most of the organs of these pigs showed less antigenicity to the human body. However, wild-type adult pig islets (API) that originally contained negligible levels of α-galactosidase now showed a clear antigenicity to human serum. In t
- PMID 24100142
- Sialyl-glycoconjugates in cholesterol-rich microdomains of P388 cells are the triggers for apoptosis induced by Rana catesbeiana oocyte ribonuclease.
- Ogawa Y, Sugawara S, Tatsuta T, Hosono M, Nitta K, Fujii Y, Kobayashi H, Fujimura T, Taka H, Koide Y, Hasan I, Matsumoto R, Yasumitsu H, Kanaly RA, Kawsar SM, Ozeki Y.Author information Divisions of Microbiology and Functional Morphology, Department of Pharmacy, Faculty of Pharmaceutical Science, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, 859-3298, Japan, yogawa@niu.ac.jp.AbstractSBL/RC-RNase was originally isolated from frog (Rana catesbeiana) oocytes and purified as a novel sialic acid-binding lectin (SBL) that displayed strong anti-cancer activity. SBL was later shown to be identical to a ribonuclease (RC-RNase) from oocytes of the same species. The administration of SBL/RC-RNase induced apoptosis (with nuclear condensation and DNA fragmentation) in mouse leukemia P388 cells but did not kill umbilical vein endothelial or fibroblast cells derived from normal tissues. The cytotoxic activity of SBL/RC-RNase was inhibited by desialylation of P388 cells and/or the co-presence of free bovine submaxillary mucin. FACS analysis showed that SBL/RC-RNase was incorporated into cells after attachment to cholesterol-rich microdomains. Addition of the cholesterol remover methyl-β-cyclodextrin reduced SBL/RC-RNase-induced apoptosis. Apoptosis occurred through the caspase-3 pathway following activation of caspase-8 by SBL/RC-RNase. A heat shock cognate protein (Hsc70) and a heat shock protein (Hsp70) (each 70 kDa) on the cell membrane were shown to bind to SBL/RC-RNase by mass spectrometric and flow cytometric analyses. Quercetin, an inhibitor of Hsc70 and Hsp70, significantly reduced SBL/RC-RNase-induced apoptosis. Taken together, our findings suggest that sialyl-glycoconjugates present in cholesterol-rich microdomains form complexes with Hsc70 or Hsp70 that act as triggers for SBL/RC-RNase to induce apoptosis through a pathway involving the activation of caspase-3 and caspase-8.
- Glycoconjugate journal.Glycoconj J.2014 Feb;31(2):171-84. doi: 10.1007/s10719-013-9513-7. Epub 2013 Nov 24.
- SBL/RC-RNase was originally isolated from frog (Rana catesbeiana) oocytes and purified as a novel sialic acid-binding lectin (SBL) that displayed strong anti-cancer activity. SBL was later shown to be identical to a ribonuclease (RC-RNase) from oocytes of the same species. The administration of SBL/
- PMID 24271942
Japanese Journal
- Expression of Long-form N-Acetylglucosamine-6-O-Sulfotransferase 1 in Human High Endothelial Venules
- Fujiwara Maiko,Kobayashi Motohiro,Hoshino Hitomi,Uchimura Kenji,Nakada Tsutomu,Masumoto Junya,Sakai Yasuhiro,Fukuda Minoru,Nakayama Jun
- JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60(5), 397-407, 2012-05
- … Two members of the N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) family, GlcNAc6ST-1 and GlcNAc6ST-2, function in the biosynthesis of 6-sulfo sialyl Lewis X-capped glycoproteins expressed on high endothelial venules (HEVs) in secondary lymphoid organs. …
- NAID 120005199156
- 進行大腸癌における術前血中 sialyl Lewis^X 値測定の有用性に関する検討
- 内藤 善久,橋口 陽二郎,識名 敦,神藤 英二,上野 秀樹,望月 英隆,山本 順司,長谷 和生
- 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 73(3), 521-526, 2012-03-25
- NAID 10030762013
- Effect of glycosylation on biodistribution of radiolabeled glucagon-like peptide 1
- Watanabe Ayahisa,Nishijima Ken-ichi,Zhao Songji,Tanaka Yoshikazu,Itoh Takeshi,Takemoto Hiroshi,Tamaki Nagara,Kuge Yuji
- Annals of Nuclear Medicine 26(2), 184-191, 2012-02
- … Methods: Noninvasive imaging studies were performed using a gamma camera after the intravenous administration of 123I-GLP-1 or 123I-α2, 6-sialyl N-acetyllactosamine (glycosylated) GLP-1 in rats. …
- NAID 80022326200
Related Links
- Table I Structures of carbohydrade antigens 1995年1月 Alberta, Canada), 抗 sialyl Lewisa(SLA)モ ノク ローナル抗体;NS19 9(IgGl)は トーレ・フジバイオ エクス社(池袋,豊島区,東京)より購入し,抗LewisX (LX)モノクローナル抗体;NCC‐Lu‐279 ...
- [Anti-Sialyl Lewis A Monoclonal Antibody (1H4)] [] | 価格や在庫、物性値などの詳細情報ページです。 ... ・川口の在庫は即日，つくばの在庫は2〜3日以内の出荷となります。・詳細につきましては，お手数ですが営業部までお問い合わせ ...
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「sialylation」
「sialyltransferase」
「sulfated sialyl-Lewisx」
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