WordNet

tending to select; characterized by careful choice; "an exceptionally quick and selective reader"- John Mason Brown
characterized by very careful or fastidious selection; "the school was very selective in its admissions"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
electronic equipment that increases strength of signals passing through it
informal term for information; "give me the gen on your new line of computers"

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1. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
2. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
3. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
4. 結節性硬化症の腎症状 renal manifestations of tuberous sclerosis complex
5. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency

A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.

Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ.SourceDivision of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, KY 40536-0200, USA.
Molecular biology of the cell.Mol Biol Cell.2010 Sep 15;21(18):3171-81. Epub 2010 Jul 21.
Lipins are phosphatidic acid phosphatases with a pivotal role in regulation of triglyceride and glycerophospholipid metabolism. Lipin1 is also an amplifier of PGC-1α, a nuclear coactivator of PPAR-α responsive gene transcription. Lipins do not contain recognized membrane-association domains, but i
PMID 20660155

Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling.

Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM.SourceInstitute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, Aachen, Germany. ogressner@ukaachen.de
Hepatology (Baltimore, Md.).Hepatology.2009 Jun;49(6):2021-30.
In vivo knockdown of connective tissue growth factor (CTGF/CCN2) was recently shown to attenuate the formation of experimental liver fibrosis. The secreted, cysteine-rich growth factor is proposed to adversely modulate the binding of profibrogenic transforming growth factor beta (TGF-beta) and its n
PMID 19309720

Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene