関: safrazine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/23 18:50:20」(JST)

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Safrazine (Safra) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used introduced as an antidepressant in the 1960s, and is still used in Japan today.^[1]^[2] As with all MAOIs, safrazine is contraindicated in patients using SSRIs, SSRAs, and serotonin agonists.

References

^ Yokoyama T, Karube T, Iwata N (January 1989). "Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain". The Journal of Pharmacy and Pharmacology 41 (1): 32–6. doi:10.1111/j.2042-7158.1989.tb06324.x. PMID 2565961.
^ Inoue T, Izumi T, Honma H, et al. (1996). "[Survey and treatment strategy of antidepressant-resistant depression]". Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica (in Japanese) 98 (5): 329–42. PMID 8741286.

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English Journal

[Treatment of nocturnal periodic hypoxemia with safrazine hydrochloride in a patient with Duchenne muscular dystrophy under nasal intermittent positive pressure ventilation].

Ogata K1, Nakayama T, Kawai M.
Rinsho shinkeigaku = Clinical neurology.Rinsho Shinkeigaku.1998 Aug;38(8):776-8.
PMID 9916528

[Survey and treatment strategy of antidepressant-resistant depression].

Inoue T1, Izumi T, Honma H, Ohmori T, Denda K, Kasahara T, Koyama T.
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.Seishin Shinkeigaku Zasshi.1996;98(5):329-42.
PMID 8741286

Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain.

Yokoyama T1, Karube T, Iwata N.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.1989 Jan;41(1):32-6.
PMID 2565961

Japanese Journal

NIPPV施行中のDuchenne型筋ジストロフィー患者にみとめた夜間周期性低酸素血症に対する塩酸サフラジンの治療効果

臨床神経学 38(8), 776-778, 1998-08-01
NAID 10008323130

EFFECT OF SAFRAZINE, A MONOAMINE OXIDASE INHIBITOR BEARING A HYDRAZINE-TERMINAL, ON PHENYTOIN METABOLISM IN ISOLATED RAT HEPATOCYTES

Chemical & pharmaceutical bulletin 36(1), 456-458, 1988-01-25
NAID 110003626715

Effect of safrazine, a monoamine oxidase inhibitor bearing a hydrazine-terminal, on phenytoin metabolism in isolated rat hepatocytes.

Chemical and Pharmaceutical Bulletin 36(1), 456-458, 1988
NAID 130003944036

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拡張検索	「safrazine hydrochloride」

「safrazine hydrochloride」

Safrazine
Systematic (IUPAC) name
	[3-(1,3-benzodioxol-5-yl)-1-methyl-propyl]hydrazine
Clinical data
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	33419-68-0
ATC code	None
PubChem	CID 34042
ChemSpider	31375
UNII	F5G0P5378C
Synonyms	4-benzo[1,3]dioxol-5-ylbutan-2-ylhydrazine; [3-(3,4-(methylenedioxy)phenyl)-1-butyl]hydrazine; 2-piperonylisopropylhydrazine
Chemical data
Formula	C11H16N2O2
Mol. mass	208.26 g/mol