WordNet

a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
a crystalline substance 500 times sweeter than sugar; used as a calorie-free sweetener

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1. 妊娠中の栄養 nutrition in pregnancy
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Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice.

Kasten CR1, Boehm SL 2nd2.
Behavioural brain research.Behav Brain Res.2014 Oct 1;272:238-47. doi: 10.1016/j.bbr.2014.07.011. Epub 2014 Jul 12.
The GABAB agonist baclofen has been widely researched clinically and preclinically as a treatment of alcohol use disorders (AUDs). However, the efficacy of baclofen remains uncertain. The clinically used racemic compound can be separated into separate enantiomers. These enantiomers have produced dif
PMID 25026094

Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL/6J mice: Pharmacological and molecular evidence of orexin involvement.

Alcaraz-Iborra M1, Carvajal F2, Lerma-Cabrera JM2, Valor LM3, Cubero I4.
Behavioural brain research.Behav Brain Res.2014 Oct 1;272:93-9. doi: 10.1016/j.bbr.2014.06.049. Epub 2014 Jun 29.
The orexin (OX) system has been implicated in food-reinforced behavior, food-seeking and food overconsumption. Recent evidence suggests that OX signaling might influence consumption of palatable foods with high reinforcing value depending upon the caloric status of the animal. The present study eval
PMID 24983661

Selective identification and quantification of saccharin by liquid chromatography and fluorescence detection.

Bruno SN1, Cardoso CR2, Maciel MM2, Vokac L3, da Silva Junior AI4.
Food chemistry.Food Chem.2014 Sep 15;159:309-15. doi: 10.1016/j.foodchem.2014.03.001. Epub 2014 Mar 14.
High-pressure liquid chromatography with ultra-violet detection (HPLC-UV) is one of the most commonly used methods to identify and quantify saccharin in non-alcoholic beverages. However, due to the wide variety of interfering UV spectra in saccharin-containing beverage matrices, the same method cann
PMID 24767060

Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists

Nakagawa Yuko,Nagasawa Masahiro,Mogami Hideo,Lohse Martin,Ninomiya Yuzo,Kojima Itaru
Endocrine Journal 60(10), 1191-1206, 2013
… Conversely, an artificial sweetener saccharin induced sustained elevation of [cAMP]i but did not increase [Ca2+]i. …
NAID 130004770393

Urinary Bladder Carcinogenesis by DNA Reactive and Non-Reactive Chemicals: Non-Linearities and Thresholds

Cohen Samuel M.
Genes and Environment 34(4), 165-170, 2012
… A more definitive threshold response is illustrated for the formation of urinary solids, either calculi (melamine) amorphous calcium phosphate-containing precipitate (sodium saccharin) or crystalluria (PPARγ agonists). …
NAID 130004943647

赤田弘正 [他],樋出守世,岡田昭五郎
口腔衛生学会雑誌 22(3), 316-324, 1972
フッ化物と歯磨剤配合成分との適合性を検討するために, フツ化物溶液と基剤その他の配合成分を混和した場合の, 可溶性フッ素量およびスズ量, エナメル質粉末へのとりこみフツ素量, スズ量, ならびに作用後エナメル質粉末の耐酸性効果を比較検討した。<BR>1) 歯磨基剤の影響<BR>(1) 0.2%NaF, (2) 0.2%NaF-0.1M・H<SUB>3</S …
NAID 130001312722