WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"
causing motion or action or change (同)actuating

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. T-B-NK+ SCID：病因および遺伝学 t b nk scid pathogenesis and genetics
2. 複合免疫不全 combined immunodeficiencies
3. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
4. T-B-NK+ SCID：臨床症状、診断、および治療 t b nk scid clinical manifestations diagnosis and treatment
5. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency

MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.

Johnson RM1, Papp E2, Grandal I3, Kowalski PE3, Nutter L3, Wong RC4, Joseph-George AM5, Danska JS6, Guidos CJ1.
Genes & development.Genes Dev.2014 Jun 1;28(11):1179-90. doi: 10.1101/gad.240820.114.
During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant transformation during B-cell development.
PMID 24888589

Severe combined immunodeficiency in Serbia and Montenegro between years 1986 and 2010: a single-center experience.

Pasic S1, Vujic D, Veljković D, Slavkovic B, Mostarica-Stojkovic M, Minic P, Minic A, Ristic G, Giliani S, Villa A, Sobacchi C, Lilić D, Abinun M.
Journal of clinical immunology.J Clin Immunol.2014 Apr;34(3):304-8. doi: 10.1007/s10875-014-9991-9. Epub 2014 Feb 1.
Severe combined immunodeficiency (SCID), including the 'variant' Omenn syndrome (OS), represent a heterogeneous group of monogenic disorders characterized by defect in differentiation of T- and/or B lymphocytes and susceptibility to infections since birth. In the period of 25 years, between January
PMID 24481607

Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.

Lorès P1, Vernet N2, Kurosaki T3, Van de Putte T4, Huylebroeck D4, Hikida M5, Gacon G1, Touré A6.
Developmental biology.Dev Biol.2014 Feb 15;386(2):419-27. doi: 10.1016/j.ydbio.2013.12.006. Epub 2013 Dec 16.
MgcRacGAP (RACGAP1) is a GTPase Activating Protein (GAP), highly produced in the mouse embryonic brain and in the human and mouse post-natal testis. MgcRacGAP negatively controls the activity of Rac and Cdc42, which are key molecular switches acting on the microtubule and actin cytoskeleton and cont
PMID 24355749

Complete arrest from pro-to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations